{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T05:19:43Z","timestamp":1793164783516,"version":"4.5.0"},"reference-count":12,"publisher":"American Academy of Pediatrics (AAP)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>The medical establishment continues to be complicit in the degradation of native peoples of the United States through the use of the racist phrase \u201cred man syndrome\u201d (RMS) to describe the histamine-release syndrome that accompanies vancomycin infusion.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Five months after the transition from 1 electronic health record to another at our freestanding children\u2019s hospital, our antimicrobial stewardship team reviewed all active allergy records to identify and then replace use of RMS terminology with preferred alternative \u201cvancomycin flushing syndrome.\u201d In partnership with institutional stakeholders, we also launched an educational campaign and instituted in the electronic health record an autocorrect functionality to prevent new RMS entries.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>We identified allergy records for 21\u2009034 individual patients. Vancomycin was an allergen for 445 (2.1%) patients, and RMS-related terminology appeared in 274 (61.6%) of these records; we replaced all RMS instances with the vancomycin flushing syndrome term. During the 3-month period after the intervention, we identified allergy records for 8648 additional patients, with vancomycin as allergen in 65 (0.7%) and with RMS terminology identified and replaced in 29 (44.6%). In addition to the lower rate of RMS among allergy records after the intervention, we detected 3 instances of alternative terminology use.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Implementing an institutional-level change in terminology, even for racist language, requires education, reinforcement, and continued surveillance. To effectively replace this term, we need the support of national stakeholders to remove this language from our medical education systems, our textbooks, and our clinical lexicon.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/hpeds.2021-005993","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T09:35:18Z","timestamp":1635759318000},"page":"e317-e321","source":"Crossref","is-referenced-by-count":4,"title":["Flushing an Offensive Term for Vancomycin Infusion Reaction From the Electronic Medical Record"],"prefix":"10.1542","volume":"11","author":[{"given":"Victoria J.L.","family":"Konold","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam W.","family":"Brothers","sequence":"additional","affiliation":[{"name":"Departments of Pharmacy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Kronman","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Pak","sequence":"additional","affiliation":[{"name":"Departments of Pharmacy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan","family":"Bettinger","sequence":"additional","affiliation":[{"name":"Clinical Analytics, School of Medicine, University of Washington and Seattle Children\u2019s Hospital, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott J.","family":"Weissman","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2021,11,1]]},"reference":[{"key":"2021121010313469300_b1","unstructured":"US Department of Health and Human Services, Indian Health Service. Disparities. 2019. Available at: https:\/\/www.ihs.gov\/newsroom\/factsheets\/disparities. Accessed March 24, 2021"},{"issue":"4","key":"2021121010313469300_b2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1056\/NEJM198501243120416","article-title":"Vancomycin and the \u201cred man\u2019s syndrome\u201d","volume":"312","author":"Garrelts","year":"1985","journal-title":"N Engl J Med"},{"issue":"7","key":"2021121010313469300_b3","first-page":"509","article-title":"\u201cRed man syndrome:\u201d thoughts on an anachronistic term","volume":"45","author":"Bradford","year":"2013","journal-title":"Fam Med"},{"issue":"8696","key":"2021121010313469300_b4","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/0140-6736(90)91069-M","article-title":"Red men should go: vancomycin and histamine release","volume":"335","year":"1990","journal-title":"Lancet"},{"issue":"7","key":"2021121010313469300_b5","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1542\/hpeds.2020-0125","article-title":"Replace red man syndrome with vancomycin flushing reaction","volume":"10","author":"Austin","year":"2020","journal-title":"Hosp Pediatr"},{"issue":"14","key":"2021121010313469300_b6","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1056\/NEJMp2031891","article-title":"Vancomycin infusion reaction - moving beyond \u201cred man syndrome\u201d","volume":"384","author":"Alvarez-Arango","year":"2021","journal-title":"N Engl J Med"},{"issue":"2","key":"2021121010313469300_b7","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.jaip.2020.09.027","article-title":"Vancomycin hypersensitivity reactions documented in electronic health records","volume":"9","author":"Alvarez-Arango","year":"2021","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"4","key":"2021121010313469300_b8","doi-asserted-by":"crossref","first-page":"e2021050498","DOI":"10.1542\/peds.2021-050498","article-title":"Caring for American Indian and Alaska Native children and adolescents","volume":"147","author":"Bell","year":"2021","journal-title":"Pediatrics"},{"key":"2021121010313469300_b9","unstructured":"Weller\u2008P\n          . Vancomycin hypersensitivity. Available at: https:\/\/www.uptodate.com\/contents\/vancomycin-hypersensitivity?search=red%20man%20syndrome&source=search_result&selectedTitle=1\u223c42&usage_type=default&display_rank=1#H1904250082. Accessed June 9, 2021"},{"key":"2021121010313469300_b10","unstructured":"LexiComp. Vancomycin monograph (pediatric and neonatal Lexi-Drugs), adverse reactions. Available at: www.crlonline.com\/lco\/action\/doc\/retrieve\/docid\/pdh_f\/129782?cesid=ajDqvYo99Wa&searchUrl=%2Flco%2Faction%2Fsearch%3Fq%3Dvancomycin%26t%3Dname%26va%3Dvancomycin. Accessed June 9, 2021"},{"key":"2021121010313469300_b11","unstructured":"Pediatric Infectious Diseases Society. PIDS endorses new terminology: vancomycin flushing syndrome. Available at: https:\/\/pids.org\/2021\/04\/27\/pids-endorses-new-terminology-vancomycin-flushing-syndrome\/. Accessed June 9, 2021"},{"key":"2021121010313469300_b12","unstructured":"Infectious Diseases Society of America. Position on terminology for vancomycin flushing reactions. Available at: https:\/\/www.idsociety.org\/globalassets\/idsa\/public-health\/covid-19\/vanc-flushing-syndrome-idsa-position-statement.pdf. Accessed June 9, 2021"}],"container-title":["Hospital Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/hospitalpediatrics\/article-pdf\/11\/11\/e317\/1192012\/hpeds_2021-005993.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/hospitalpediatrics\/article-pdf\/11\/11\/e317\/1192012\/hpeds_2021-005993.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T23:09:10Z","timestamp":1639177750000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/hospitalpediatrics\/article\/11\/11\/e317\/181238\/Flushing-an-Offensive-Term-for-Vancomycin-Infusion"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,1]]},"references-count":12,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,11,1]]},"published-print":{"date-parts":[[2021,11,1]]}},"URL":"https:\/\/doi.org\/10.1542\/hpeds.2021-005993","relation":{},"ISSN":["2154-1663","2154-1671"],"issn-type":[{"value":"2154-1663","type":"print"},{"value":"2154-1671","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,1]]}}}