{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T14:54:22Z","timestamp":1779893662586,"version":"3.53.1"},"reference-count":44,"publisher":"American Academy of Pediatrics (AAP)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To identify associations between weight status and clinical outcomes in children with lower respiratory tract infection (LRTI) or asthma requiring hospitalization.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We performed a retrospective cohort study of 2 to 17 year old children hospitalized for LRTI and\/or asthma from 2009 to 2019 using electronic health record data from the PEDSnet clinical research network. Children &amp;lt;2 years, those with medical complexity, and those without a calculable BMI were excluded. Children were classified as having underweight, normal weight, overweight, or class 1, 2, or 3 obesity based on Body Mass Index percentile for age and sex. Primary outcomes were need for positive pressure respiratory support and ICU admission. Subgroup analyses were performed for children with a primary diagnosis of asthma. Outcomes were modeled with mixed-effects multivariable logistic regression incorporating age, sex, and payer as fixed effects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>We identified 65\u2009132 hospitalizations; 6.7% with underweight, 57.8% normal weight, 14.6% overweight, 13.2% class 1 obesity, 5.0% class 2 obesity, and 2.8% class 3 obesity. Overweight and obesity were associated with positive pressure respiratory support (class 3 obesity versus normal weight odds ratio [OR] 1.62 [1.38\u20131.89]) and ICU admission (class 3 obesity versus normal weight OR 1.26 [1.12\u20131.42]), with significant associations for all categories of overweight and obesity. Underweight was also associated with positive pressure respiratory support (OR 1.39 [1.24\u20131.56]) and ICU admission (1.40 [1.30\u20131.52]).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Both underweight and overweight or obesity are associated with increased severity of LRTI or asthma in hospitalized children.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/hpeds.2021-006404","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T08:07:58Z","timestamp":1657699678000},"page":"734-743","source":"Crossref","is-referenced-by-count":4,"title":["Associations Between Weight and Lower Respiratory Tract Disease Outcomes in Hospitalized Children"],"prefix":"10.1542","volume":"12","author":[{"given":"Elizabeth E.","family":"Halvorson","sequence":"first","affiliation":[{"name":"aDepartments of Pediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Saha","sequence":"additional","affiliation":[{"name":"bAnesthesiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher B.","family":"Forrest","sequence":"additional","affiliation":[{"name":"cApplied Clinical Research Center, Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanieh","family":"Razzaghi","sequence":"additional","affiliation":[{"name":"cApplied Clinical Research Center, Children\u2019s Hospital of Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Brittan","sequence":"additional","affiliation":[{"name":"dDepartment of Pediatrics, University of Colorado School of Medicine and Children\u2019s Hospital Colorado, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri A","family":"Christakis","sequence":"additional","affiliation":[{"name":"eDepartment of Pediatrics, University of Washington and Seattle Children\u2019s Hospital, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Sessions","family":"Cole","sequence":"additional","affiliation":[{"name":"fEdward Mallinckrodt Department of Pediatrics, Washington University School of Medicine and St. Louis Children\u2019s Hospital, St. Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asuncion","family":"Mejias","sequence":"additional","affiliation":[{"name":"gDivision of Infectious Diseases, Department of Pediatrics, Nationwide Children\u2019s Hospital and The Ohio State University, Columbus, Ohio;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thao-Ly Tam","family":"Phan","sequence":"additional","affiliation":[{"name":"hDepartment of Pediatrics, Nemours Children\u2019s Health System, Wilmington, Delaware"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"McCrory","sequence":"additional","affiliation":[{"name":"bAnesthesiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian 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