{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T14:52:09Z","timestamp":1746715929171,"version":"3.40.5"},"reference-count":19,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVES:<\/jats:title>\n                  <jats:p>Overweight negatively affects pediatric respiratory function. In this study, we evaluate if overweight is associated with more severe bronchiolitis in hospitalized infants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS:<\/jats:title>\n                  <jats:p>This retrospective cohort study analyzed infants aged 30 to 365 days hospitalized for bronchiolitis from September 2019 to April 2020. Exclusion criteria included known risk factors for severe bronchiolitis, asthma treatment, or bacterial pneumonia. Weight-for-length z-score was categorized per the World Health Organization\u2019s growth assessments as overweight (z-score &amp;gt;2), underweight (z-score &amp;lt;\u22122), and standard weight (between \u22122 and \u22642). Primary outcomes included respiratory support, ICU stay, and local bronchiolitis score. Secondary outcomes included supplemental interventions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS:<\/jats:title>\n                  <jats:p>After exclusion criteria, 385 of 644 infants were categorized as overweight (n = 24), standard (n = 335), or underweight (n = 26). There were differences in need for respiratory support (overweight, 100%; standard weight, 81.8%; underweight, 76.9%; P = .03), highest support of high-flow nasal cannula (overweight, 75%; standard weight, 48%; underweight, 42%; P = .03), admission to ICU (overweight, 54.2%; standard weight, 21.5%; underweight, 34.7%; P &amp;lt; .001), and median bronchiolitis score (overweight, 8 [interquartile range 5\u201310]; standard weight, 4 [3\u20137]; underweight, 4 [3\u20137]; P = .01). Findings remained significant after age adjustments. Additionally, overweight experienced higher frequency of certain treatments.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS:<\/jats:title>\n                  <jats:p>This study suggests overweight is associated with more severe bronchiolitis in hospitalized infants supported by increased respiratory support level, bronchiolitis scores, and interventions. Higher need for ICU admission may be related to high-flow nasal cannula limitations on the acute care floor.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/hpeds.2022-006746","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T08:06:19Z","timestamp":1671177979000},"page":"e6-e10","source":"Crossref","is-referenced-by-count":1,"title":["Overweight Infants Hospitalized for Bronchiolitis Associated With Severe Disease"],"prefix":"10.1542","volume":"13","author":[{"given":"Leann","family":"Madion","sequence":"first","affiliation":[{"name":"aDepartment of Pediatrics, Divisions of Hospital Medicine"},{"name":"bChildren\u2019s Wisconsin, Milwaukee, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah Corey","family":"Bauer","sequence":"additional","affiliation":[{"name":"aDepartment of Pediatrics, Divisions of Hospital Medicine"},{"name":"bChildren\u2019s Wisconsin, Milwaukee, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Pan","sequence":"additional","affiliation":[{"name":"cQuantitative Health Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiva","family":"Parakininkas","sequence":"additional","affiliation":[{"name":"bChildren\u2019s Wisconsin, Milwaukee, Wisconsin"},{"name":"dPulmonology"},{"name":"eCritical Care, Medical College of Wisconsin, Milwaukee, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Karls","sequence":"additional","affiliation":[{"name":"bChildren\u2019s Wisconsin, Milwaukee, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"McFadden","sequence":"additional","affiliation":[{"name":"aDepartment of Pediatrics, Divisions of Hospital Medicine"},{"name":"bChildren\u2019s Wisconsin, Milwaukee, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracey","family":"Liljestrom","sequence":"additional","affiliation":[{"name":"aDepartment of Pediatrics, Divisions of Hospital Medicine"},{"name":"bChildren\u2019s Wisconsin, Milwaukee, Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2022,12,16]]},"reference":[{"key":"2023112713475007400_b1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/B978-1-4377-1984-0.00043-7","article-title":"43: Chest wall and respiratory muscle disorders","volume-title":"Kendig & Chernick\u2019s Disorders of the Respiratory Tract in Children","author":"Praud","year":"2012","edition":"Eighth Edition"},{"issue":"3","key":"2023112713475007400_b2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/(SICI)1099-0496(199709)24:3<187::AID-PPUL4>3.0.CO;2-K","article-title":"Effects of body fat on ventilatory function in children and adolescents: cross-sectional findings from a random population sample of school children","volume":"24","author":"Lazarus","year":"1997","journal-title":"Pediatr Pulmonol"},{"issue":"9","key":"2023112713475007400_b3","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1080\/17476348.2018.1506331","article-title":"The effect of obesity on lung function","volume":"12","author":"Dixon","year":"2018","journal-title":"Expert Rev Respir Med"},{"issue":"3","key":"2023112713475007400_b4","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1136\/thx.2006.064642","article-title":"Associations between postnatal weight gain, change in postnatal pulmonary function, formula feeding and early asthma","volume":"63","author":"Turner","year":"2008","journal-title":"Thorax"},{"issue":"2","key":"2023112713475007400_b5","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1164\/rccm.201703-0631OC","article-title":"Fetal and infant growth patterns and risk of lower lung function and asthma. 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