{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T15:44:38Z","timestamp":1773330278349,"version":"3.50.1"},"reference-count":29,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,1]]},"abstract":"\n OBJECTIVES<\/jats:title>\n To describe the epidemiology and complications of platelet transfusions among hospitalized pediatric patients during 2010 to 2019.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n We performed a retrospective cohort study of hospitalized children within the Pediatric Health Information System database. Pediatric encounters receiving at least one platelet transfusion during hospitalization from 2010 to 2019 were identified. Data regarding demographics, diagnoses, procedures required during hospitalization, complications, and outcomes were extracted for eligible encounters.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n Within the Pediatric Health Information System database, 6\u2009284\u2009264 hospitalizations occurred from 2010 to 2019. A total of 244\u2009464 hospitalizations required at least one platelet transfusion, yielding a prevalence of 3.89% (95% confidence interval [CI], 3.87%\u20133.91%). Transfusion prevalence did not change significantly across the decade (P value = .152). Two-thirds of children receiving platelet transfusions were in their first 6 years of life, and the majority identified as male (55%). Recipients most commonly had diseases of the circulatory system (21%, 52\u2009008 of 244\u2009979), perinatal disorders (16%, 38\u2009054 of 244\u2009979), or diseases of the hematologic\/immune systems (15%, 37\u2009466 of 244\u2009979). When adjusted for age, support by extracorporeal membrane oxygenation, mechanical ventilation, surgical intervention, and diagnostic category, the odds of thrombosis, infection, and mortality increased by 2% (odds ratio [OR], 1.02; 95% CI, 1.016\u20131.020), 3% (OR, 1.03; 95% CI, 1.028\u20131.033), and 7% (OR, 1.07; 95% CI, 1.067\u20131.071), respectively, with each additional transfusion.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n The prevalence of platelet transfusions among pediatric inpatients remained consistent across the decade. Our finding that increasing numbers of transfusions may be associated with elevated morbidity and mortality is consistent with other observation and experimental studies, highlighting the need to be thoughtful in weighing risks and benefits when prescribing repeated platelet transfusions to hospitalized children.<\/jats:p>\n <\/jats:sec>","DOI":"10.1542\/hpeds.2022-006832","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T03:10:16Z","timestamp":1678072216000},"page":"283-292","source":"Crossref","is-referenced-by-count":4,"title":["Epidemiology of Platelet Transfusions in Hospitalized Children: A Pediatric Hospital Information System Database Study"],"prefix":"10.1542","volume":"13","author":[{"given":"Emily A.","family":"Lang","sequence":"first","affiliation":[{"name":"aDoctoral Program"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjile","family":"An","sequence":"additional","affiliation":[{"name":"bDivision of Biostatistics, 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