{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:47:35Z","timestamp":1790880455528,"version":"4.1.0"},"reference-count":16,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND AND OBJECTIVES<\/jats:title>\n                  <jats:p>Growth faltering (GF) (previously failure to thrive) is a common reason for hospital admission, but there is little data on whether diagnoses made during initial admission remain accurate in follow-up. We sought to characterize infants admitted for isolated GF and identify diagnoses at discharge and ultimate diagnoses determined over 2 years of follow-up, to determine how diagnoses changed. We also sought to identify patient factors on admission associated with ultimate diagnosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We conducted a retrospective study of children aged 2 weeks to 2 years with index admissions for GF from 2013 to 2017. We reviewed clinical data and documentation to determine discharge and ultimate diagnosis, and identify factors associated with ultimate diagnosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Of 497 patients, 292 (59%) had insufficient intake, 103 (20%) had organic disease including 36 genetic disorders, 52 (11%) had mechanical feeding difficulties, and 50 (10%) had mixed or unknown diagnoses 2 years after admission. Over 90% of cases of insufficient intake were diagnosed during admission. Sixty-five percent of organic diseases, and only 39% of genetic disorders, were diagnosed during admission. Patient factors associated with genetic disorders included previous NICU stay, low birth weight, dysphagia, hypotonia, and dysmorphisms.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Insufficient intake remains the most common diagnosis, and this diagnosis was accurately made during admission. Organic disease, especially genetic disease, was often not diagnosed during admission. Better tools are needed to identify patients with organic disease. We identified patient factors on admission associated with ultimate diagnosis, which could be used to prioritize evaluation and expedite follow-up.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/hpeds.2022-007038","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T08:19:54Z","timestamp":1682065194000},"page":"394-402","source":"Crossref","is-referenced-by-count":11,"title":["Etiologies of Poor Weight Gain and Ultimate Diagnosis in Children Admitted for Growth Faltering"],"prefix":"10.1542","volume":"13","author":[{"given":"Elise","family":"Peterson Lu","sequence":"first","affiliation":[{"name":"aPaul C. Gaffney Division of Pediatric Hospital Medicine"},{"name":"bDepartments of Pediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Bowen","sequence":"additional","affiliation":[{"name":"cDivision of Hospital Medicine, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Foglia","sequence":"additional","affiliation":[{"name":"dCritical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Ribar","sequence":"additional","affiliation":[{"name":"eDepartment of Pediatrics, Children\u2019s Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"Mack","sequence":"additional","affiliation":[{"name":"fDivisions of Pediatric Hematology\/Oncology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esha","family":"Sondhi","sequence":"additional","affiliation":[{"name":"dCritical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Hickey","sequence":"additional","affiliation":[{"name":"bDepartments of Pediatrics"},{"name":"gPediatric Emergency Medicine, UPMC Children\u2019s Hospital of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2023,4,21]]},"reference":[{"issue":"11","key":"2023112714003600200_b1","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1542\/pir.2020-001883","article-title":"Failure to thrive or growth faltering: medical, developmental\/behavioral, nutritional, and social dimensions","volume":"42","author":"Tang","year":"2021","journal-title":"Pediatr Rev"},{"issue":"2","key":"2023112714003600200_b2","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1177\/0009922817698803","article-title":"Hospitalization for failure to thrive: a prospective descriptive report","volume":"57","author":"Larson-Nath","year":"2018","journal-title":"Clin Pediatr (Phila)"},{"issue":"9","key":"2023112714003600200_b3","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1542\/pir.1-9-265","article-title":"Nonorganic failure-to-thrive","volume":"1","author":"Berwick","year":"1980","journal-title":"Pediatr Rev"},{"issue":"3","key":"2023112714003600200_b4","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1542\/pir.32.3.100","article-title":"Failure to thrive: current clinical concepts","volume":"32","author":"Jaffe","year":"2011","journal-title":"Pediatr Rev"},{"issue":"5","key":"2023112714003600200_b5","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1136\/adc.57.5.347","article-title":"Failure to thrive: diagnostic yield of hospitalization","volume":"57","author":"Berwick","year":"1982","journal-title":"Arch Dis Child"},{"issue":"10","key":"2023112714003600200_b6","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1542\/hpeds.2018-0035","article-title":"The diagnostic accuracy of in-hospital weight gain for differentiating neglect from other failure to thrive etiologies","volume":"8","author":"Puls","year":"2018","journal-title":"Hosp Pediatr"},{"issue":"1 Pt 2","key":"2023112714003600200_b7","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1542\/peds.106.S1.205","article-title":"Pediatric deaths attributable to complex chronic conditions: a population-based study of Washington State, 1980\u20131997","volume":"106","author":"Feudtner","year":"2000","journal-title":"Pediatrics"},{"issue":"8","key":"2023112714003600200_b8","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1177\/0009922808316989","article-title":"Etiology of failure to thrive in infants and toddlers referred to a pediatric endocrinology outpatient clinic","volume":"47","author":"Daniel","year":"2008","journal-title":"Clin Pediatr (Phila)"},{"issue":"3","key":"2023112714003600200_b9","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/0009922811421001","article-title":"Characteristics of failure to thrive in a referral population: implications for treatment","volume":"51","author":"Atalay","year":"2012","journal-title":"Clin Pediatr (Phila)"},{"key":"2023112714003600200_b10","doi-asserted-by":"crossref","first-page":"e5931","DOI":"10.1136\/bmj.e5931","article-title":"Weight faltering and failure to thrive in infancy and early childhood","volume":"345","author":"Shields","year":"2012","journal-title":"BMJ"},{"issue":"10","key":"2023112714003600200_b11","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1001\/archpedi.1978.02120350031003","article-title":"Failure to thrive. The role of clinical and laboratory evaluation","volume":"132","author":"Sills","year":"1978","journal-title":"Am J Dis Child"},{"issue":"2","key":"2023112714003600200_b12","doi-asserted-by":"crossref","first-page":"e46","DOI":"10.3928\/00904481-20160114-01","article-title":"Clinical review of failure to thrive in pediatric patients","volume":"45","author":"Larson-Nath","year":"2016","journal-title":"Pediatr Ann"},{"issue":"1","key":"2023112714003600200_b13","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1542\/pir.27-1-e1","article-title":"Failure to thrive: a consequence of undernutrition","volume":"27","author":"Gahagan","year":"2006","journal-title":"Pediatr Rev"},{"issue":"5","key":"2023112714003600200_b14","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1542\/peds.2005-2032","article-title":"Failure to thrive as a manifestation of child neglect","volume":"116","author":"Block","year":"2005","journal-title":"Pediatrics"},{"issue":"8","key":"2023112714003600200_b15","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1542\/pir.21.8.257","article-title":"Failure to thrive: an old nemesis in the new millennium","volume":"21","author":"Schwartz","year":"2000","journal-title":"Pediatr Rev"},{"issue":"4","key":"2023112714003600200_b16","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/ajmg.c.31465","article-title":"The clinical geneticist and the evaluation of failure to thrive versus failure to feed","volume":"169","author":"Rabago","year":"2015","journal-title":"Am J Med Genet C Semin Med Genet"}],"container-title":["Hospital Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/hospitalpediatrics\/article-pdf\/13\/5\/394\/1574889\/hpeds.2022-007038.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/hospitalpediatrics\/article-pdf\/13\/5\/394\/1574889\/hpeds.2022-007038.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T14:07:16Z","timestamp":1701094036000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/hospitalpediatrics\/article\/13\/5\/394\/191105\/Etiologies-of-Poor-Weight-Gain-and-Ultimate"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,21]]},"references-count":16,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,4,21]]},"published-print":{"date-parts":[[2023,5,1]]}},"URL":"https:\/\/doi.org\/10.1542\/hpeds.2022-007038","relation":{},"ISSN":["2154-1663","2154-1671"],"issn-type":[{"value":"2154-1663","type":"print"},{"value":"2154-1671","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,21]]}}}