{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T15:07:45Z","timestamp":1746716865617,"version":"3.40.5"},"reference-count":11,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,1]]},"abstract":"\n BACKGROUND<\/jats:title>\n SARS-CoV-2 can potentially cause nosocomial outbreaks. Although high secondary attack rates (SARs) among adult roommates have been reported, data on pediatric settings are limited. This study aimed to evaluate the SAR of symptomatic SARS-CoV-2 infections in shared rooms in a children\u2019s hospital.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n A retrospective chart review from January 1, 2023, to December 31, 2023, was conducted at the National Center for Child Health and Development, one of the largest tertiary children\u2019s hospitals in Japan. According to hospital policy, nucleic acid amplification tests for SARS-CoV-2 were required for all hospitalized patients who developed new-onset fever or respiratory symptoms during the study period. If the test result was positive, confirmed cases with SARS-CoV-2 infection were immediately transferred to an isolation ward, and their remaining roommates were closely monitored for 5 days following the diagnosis of the index case. The SAR of symptomatic SARS-CoV-2 infections among roommates was calculated.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n Eighteen patients were identified as index cases with whom a total of 53 roommates had contact. Among these exposed roommates, secondary symptomatic SARS-CoV-2 infections occurred in 2 shared rooms, and the SAR within 5 days after the exposure from the index case was 5.7% (3\/53).<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n The SAR of symptomatic SARS-CoV-2 infections in the largest tertiary children\u2019s hospital in Japan was not high in this study. Further studies are warranted to validate our findings and to establish effective isolation and surveillance strategies for SARS-CoV-2 in hospitalized children.<\/jats:p>\n <\/jats:sec>","DOI":"10.1542\/hpeds.2024-008095","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:03:01Z","timestamp":1740009781000},"page":"e88-e92","source":"Crossref","is-referenced-by-count":0,"title":["Secondary Attack of Symptomatic SARS-CoV-2 Infections Among Roommates in a Children\u2019s Hospital"],"prefix":"10.1542","volume":"15","author":[{"given":"Tatsuki","family":"Ikuse","sequence":"first","affiliation":[{"name":"1Division of Infectious Diseases, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Yamada","sequence":"additional","affiliation":[{"name":"1Division of Infectious Diseases, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taketo","family":"Kasai","sequence":"additional","affiliation":[{"name":"1Division of Infectious Diseases, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Aiba","sequence":"additional","affiliation":[{"name":"2Infection Control Office, National Center for Child Health and Development, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Matsui","sequence":"additional","affiliation":[{"name":"1Division of Infectious Diseases, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanori","family":"Funaki","sequence":"additional","affiliation":[{"name":"1Division of Infectious Diseases, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kensuke","family":"Shoji","sequence":"additional","affiliation":[{"name":"1Division of Infectious Diseases, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ito","family":"Kato","sequence":"additional","affiliation":[{"name":"3Bacteriology Laboratory, National Center for Child Health and Development, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachiko","family":"Miura","sequence":"additional","affiliation":[{"name":"2Infection Control Office, National Center for Child Health and Development, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshie","family":"Sugahara","sequence":"additional","affiliation":[{"name":"2Infection Control Office, National Center for Child Health and Development, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chikara","family":"Ogimi","sequence":"additional","affiliation":[{"name":"1Division of Infectious Diseases, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan"},{"name":"2Infection Control Office, National Center for Child Health and Development, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2025,2,20]]},"reference":[{"issue":"1","key":"2025030606571878000_r1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13756-020-00875-7","article-title":"Nosocomial transmission and outbreaks of coronavirus disease 2019: the need to protect both patients and healthcare workers","volume":"10","author":"Abbas","year":"2021","journal-title":"Antimicrob Resist Infect Control."},{"issue":"6","key":"2025030606571878000_r2","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1542\/hpeds.2018-0222","article-title":"Room sharing in hospitalized children with bronchiolitis and the occurrence of hospital-acquired infections: a prospective cohort study","volume":"9","author":"Bekhof","year":"2019","journal-title":"Hosp Pediatr."},{"issue":"10","key":"2025030606571878000_r3","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.3201\/eid2810.220321","article-title":"Nosocomial COVID-19 incidence and secondary attack rates among patients of tertiary care center, Zurich, Switzerland","volume":"28","author":"Wolfensberger","year":"2022","journal-title":"Emerg Infect Dis."},{"issue":"3","key":"2025030606571878000_r4","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1017\/ice.2023.230","article-title":"Initial and 5-day positivity rate of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) polymerase chain reaction (PCR) in exposed inpatients within shared rooms during the omicron-variant dominant period","volume":"45","author":"Park","year":"2024","journal-title":"Infect Control Hosp Epidemiol."},{"year":"2024","author":"Tokyo Metropolitan Government Bureau of Public Health","key":"2025030606571878000_r5"},{"year":"2024","author":"Tokyo Metropolitan Government Bureau of Public Health","key":"2025030606571878000_r6"},{"issue":"1","key":"2025030606571878000_r7","doi-asserted-by":"crossref","first-page":"22453","DOI":"10.1038\/s41598-022-24643-2","article-title":"Lower SARS-CoV-2 household transmission in children and adolescents compared to adults","volume":"12","author":"Schumm","year":"2022","journal-title":"Sci Rep."},{"issue":"1","key":"2025030606571878000_r8","doi-asserted-by":"crossref","first-page":"e13913","DOI":"10.1111\/pai.13913","article-title":"Limited role of children in transmission of SARS-CoV-2 virus in households-Immunological analysis of 26 familial clusters","volume":"34","author":"Sieber","year":"2023","journal-title":"Pediatr Allergy Immunol."},{"issue":"10","key":"2025030606571878000_r9","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1093\/jpids\/piac068","article-title":"Severity of illness caused by severe acute respiratory syndrome coronavirus 2 variants of concern in children: a single-center retrospective cohort study","volume":"11","author":"Edward","year":"2022","journal-title":"J Pediatric Infect Dis Soc."},{"key":"2025030606571878000_r10","first-page":"503","article-title":"Comparison of clinical characteristics of children infected with Coronavirus disease 2019 between Omicron variant BA.5 and BA.1\/BA.2 in Japan","volume-title":"Pediatr Infect Dis J.","author":"Ikuse","year":"2023"},{"issue":"suppl 2","key":"2025030606571878000_r11","doi-asserted-by":"crossref","first-page":"S193","DOI":"10.1093\/cid\/ciac545","article-title":"Magnitude and determinants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) household transmission: a longitudinal cohort study","volume":"75","author":"Kelly","year":"2022","journal-title":"Clin Infect Dis."}],"container-title":["Hospital Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/hospitalpediatrics\/article-pdf\/15\/3\/e88\/1774629\/hosppeds.2024008095.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/hospitalpediatrics\/article-pdf\/15\/3\/e88\/1774629\/hosppeds.2024008095.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T06:57:26Z","timestamp":1741244246000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/hospitalpediatrics\/article\/15\/3\/e88\/201000\/Secondary-Attack-of-Symptomatic-SARS-CoV-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,20]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,2,20]]},"published-print":{"date-parts":[[2025,3,1]]}},"URL":"https:\/\/doi.org\/10.1542\/hpeds.2024-008095","relation":{},"ISSN":["2154-1663","2154-1671"],"issn-type":[{"type":"print","value":"2154-1663"},{"type":"electronic","value":"2154-1671"}],"subject":[],"published":{"date-parts":[[2025,2,20]]}}}