{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T14:09:13Z","timestamp":1779890953560,"version":"3.53.1"},"reference-count":27,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"\n OBJECTIVE<\/jats:title>\n While initial oral antibiotics are likely as effective as intravenous (IV) antibiotics for most children hospitalized with community-acquired pneumonia (CAP), most still receive IV therapy. We evaluated factors associated with doing well with initial oral antibiotics among children hospitalized with CAP.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n We performed a multicenter retrospective cohort study of children hospitalized with CAP who were started on oral antibiotics at 4 children\u2019s hospitals between 2014 and 2020. We performed multivariable logistic regression to evaluate the association between hospital site and patient-level factors and doing well with oral antibiotics, defined as those who remained on oral antibiotics throughout the hospitalization, did not have escalation of care during the hospitalization, and did not have readmissions or emergency department revisits within 7\u00a0days of discharge.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n Among 419 children who received initial oral antibiotics, 76% (n\u2009=\u2009317) did well with this regimen (ie, remained on orals and did not have escalation or revisits). Of those who did not do well (n\u2009=\u2009102), 80% (n\u2009=\u200982) switched to IV antibiotics but had no escalation of care or revisits. In multivariable analyses, there were no patient-level factors associated with doing well with initial oral antibiotics, and only hospital site was statistically significant.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n Most children hospitalized with CAP given initial oral antibiotics continued oral therapy and did not have escalation of care or return visits. Switching from oral to IV antibiotics may be based more on nonpatient level factors (eg, clinician preference) than patient-level factors, although prospective studies are needed.<\/jats:p>\n <\/jats:sec>","DOI":"10.1542\/hpeds.2025-008382","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:02:39Z","timestamp":1776902559000},"page":"e316-e322","source":"Crossref","is-referenced-by-count":0,"title":["Children Hospitalized With Pneumonia Who Complete Oral Antibiotic Treatment Without Complications"],"prefix":"10.1542","volume":"16","author":[{"given":"Jillian M.","family":"Cotter","sequence":"first","affiliation":[{"name":"1Section of Hospital Medicine, Department of Pediatrics, Children\u2019s Hospital Colorado, University of Colorado, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Dunn","sequence":"additional","affiliation":[{"name":"2Department of Pediatrics, Adult and Child Center for Outcomes Research and Delivery Science (ACCORDS), University of Colorado School of Medicine, Children\u2019s Hospital Colorado, University of Colorado, Aurora, Colorado"},{"name":"3Children\u2019s Hospital Association, Lenexa, Kansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek J.","family":"Williams","sequence":"additional","affiliation":[{"name":"4Division of Hospital Medicine, Department of Pediatrics, Monroe Carell Jr Children\u2019s Hospital at VUMC, Vanderbilt University School of Medicine, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sriram","family":"Ramgopal","sequence":"additional","affiliation":[{"name":"5Division of Emergency Medicine, Department of Pediatrics, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristin Q.","family":"Fritz","sequence":"additional","affiliation":[{"name":"4Division of Hospital Medicine, Department of Pediatrics, Monroe Carell Jr Children\u2019s Hospital at VUMC, Vanderbilt University School of Medicine, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maia","family":"Taft","sequence":"additional","affiliation":[{"name":"6Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt","family":"Hall","sequence":"additional","affiliation":[{"name":"2Department of Pediatrics, Adult and Child Center for Outcomes Research and Delivery Science (ACCORDS), University of Colorado School of Medicine, Children\u2019s Hospital Colorado, University of Colorado, Aurora, Colorado"},{"name":"3Children\u2019s Hospital Association, Lenexa, Kansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Temte","sequence":"additional","affiliation":[{"name":"1Section of Hospital Medicine, Department of Pediatrics, Children\u2019s Hospital Colorado, University of Colorado, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Stassun","sequence":"additional","affiliation":[{"name":"4Division of Hospital Medicine, Department of Pediatrics, Monroe Carell Jr Children\u2019s Hospital at VUMC, Vanderbilt University School of Medicine, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna","family":"Trivedi","sequence":"additional","affiliation":[{"name":"6Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Kapes","sequence":"additional","affiliation":[{"name":"5Division of Emergency Medicine, Department of Pediatrics, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Lavey","sequence":"additional","affiliation":[{"name":"5Division of Emergency Medicine, Department of Pediatrics, Ann & Robert H. Lurie Children\u2019s Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Coon","sequence":"additional","affiliation":[{"name":"7Department of Pediatrics, University of Seattle, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Kempe","sequence":"additional","affiliation":[{"name":"2Department of Pediatrics, Adult and Child Center for Outcomes Research and Delivery Science (ACCORDS), University of Colorado School of Medicine, Children\u2019s Hospital Colorado, University of Colorado, Aurora, Colorado"},{"name":"3Children\u2019s Hospital Association, Lenexa, Kansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilliam","family":"Ambroggio","sequence":"additional","affiliation":[{"name":"8Sections of Hospital Medicine and Emergency Medicine, Department of Pediatrics, Children\u2019s Hospital 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