{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T18:16:21Z","timestamp":1758824181919,"version":"3.40.5"},"reference-count":28,"publisher":"American Academy of Pediatrics (AAP)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:p>Therapeutic hypothermia (TH) mitigates the long-term effects of neuronal excitotoxicity and cell death seen in hypoxic-ischemic encephalopathy (HIE). It remains the most evidence-based therapy for HIE, but it is not without clinical controversy. The literature abounds with questions, such as \u201cWhen should we start cooling\u2014as early as the delivery room?\u201d \u201cGiven the efficacy of TH for moderate to severe HIE when started within 6 hours of birth, can we expand the therapy to infants with mild HIE?\u201d \u201cWhat should the target temperature be?\u201d \u201cWhat is the optimal duration of treatment?\u201d \u201cIs early discontinuation acceptable if the examination findings normalize?\u201d These questions about TH, its incomplete neurologic rescue, and variations in the delivery of this therapy have prompted this review. This article summarizes changing procedural considerations for TH, the level of neuromonitoring available, the use of sedation, and considerations for neuroimaging during and after TH.<\/jats:p>","DOI":"10.1542\/neo.20-9-e513","type":"journal-article","created":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T13:25:16Z","timestamp":1567430716000},"page":"e513-e519","source":"Crossref","is-referenced-by-count":6,"title":["Caveats of Cooling: Available Evidence and Ongoing Investigations of Therapeutic Hypothermia"],"prefix":"10.1542","volume":"20","author":[{"given":"Joanna","family":"Parga-Belinkie","sequence":"first","affiliation":[{"name":"Division of Neonatology, Children\u2019s Hospital of Philadelphia, Philadelphia, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth E.","family":"Foglia","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Children\u2019s Hospital of Philadelphia, Philadelphia, 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