{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T06:45:39Z","timestamp":1787813139471,"version":"build-2784847793"},"reference-count":70,"publisher":"American Academy of Pediatrics (AAP)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:p>In view of the known complications of drug therapy and open surgical ligation, and the potential for prolonged patent ductus arteriosus (PDA) exposure to be harmful, health care practitioners have sought new approaches to achieve definitive ductal closure. Interest in percutaneous (catheter-based) PDA closure has emerged within the neonatal community as a viable treatment option, because it has been fueled by recent procedural and device modifications, as well as mounting feasibility and safety data. Herein, we provide a contemporary review of percutaneous PDA closure among infants at the crux of the medical debate\u2014very-low-weight infants (\u22641,500 g), including: 1) characterization of traditional PDA treatments (drug therapy, open surgical ligation) and conservative (nonintervention) management options; 2) a general overview of the major procedural steps of percutaneous ductal closure, including efforts to reduce thrombotic complications and the emergence of a novel US Food and Drug Administration\u2013approved device; 3) a systematic review and meta-analysis to better understand risk profiles of percutaneous PDA closure in this population; and 4) discussion of current gaps in our understanding of optimal PDA care, including the critical need for well-designed, randomized, controlled clinical trials.<\/jats:p>","DOI":"10.1542\/neo.21-7-e469","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T13:24:36Z","timestamp":1593609876000},"page":"e469-e478","source":"Crossref","is-referenced-by-count":10,"title":["Percutaneous Closure of the Patent Ductus Arteriosus in Very-Low-Weight Infants"],"prefix":"10.1542","volume":"21","author":[{"given":"Danielle","family":"Scerbo","sequence":"first","affiliation":[{"name":"The Ohio University Heritage College of Osteopathic Medicine, Athens, OH"},{"name":"Center for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford L.","family":"Cua","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH"},{"name":"The Heart Center, Nationwide Children\u2019s Hospital, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian K.","family":"Rivera","sequence":"additional","affiliation":[{"name":"Center for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura C.","family":"Marzec","sequence":"additional","affiliation":[{"name":"Center for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles V.","family":"Smith","sequence":"additional","affiliation":[{"name":"Center for Integrated Brain Research, Seattle Children\u2019s Hospital, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan L.","family":"Slaughter","sequence":"additional","affiliation":[{"name":"Center for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, OH"},{"name":"Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH"},{"name":"Division of Neonatology, Nationwide Children\u2019s Hospital, Columbus, OH"},{"name":"Division of Epidemiology, The Ohio State University College of Public Health, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren P.","family":"Berman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH"},{"name":"The Heart Center, Nationwide Children\u2019s Hospital, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl H.","family":"Backes","sequence":"additional","affiliation":[{"name":"Center for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, OH"},{"name":"Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH"},{"name":"The Heart 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