{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:43:43Z","timestamp":1793313823090,"version":"4.5.0"},"reference-count":91,"publisher":"American Academy of Pediatrics (AAP)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:p>Congenital diaphragmatic hernia (CDH) results in abdominal contents entering the thoracic cavity, affecting both cardiac and pulmonary development. Maldevelopment of the pulmonary vasculature occurs within both the ipsilateral lung and the contralateral lung. The resultant bilateral pulmonary hypoplasia and associated pulmonary hypertension are important components of the pathophysiology of this disease that affect outcomes. Despite prenatal referral to specialized high-volume centers, advanced ventilation strategies, pulmonary hypertension management, and the option of extracorporeal membrane oxygenation, overall CDH mortality remains between 25% and 30%. With increasing recognition that cardiac dysfunction plays a large role in morbidity and mortality in patients with CDH, it becomes imperative to understand the different clinical phenotypes, thus allowing for individual patient-directed therapies. Further research into therapeutic interventions that address the cardiopulmonary interactions in patients with CDH may lead to improved morbidity and mortality outcomes.<\/jats:p>","DOI":"10.1542\/neo.24-11-e720","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T03:11:01Z","timestamp":1698808261000},"page":"e720-e732","source":"Crossref","is-referenced-by-count":21,"title":["Unique Cardiopulmonary Interactions in Congenital Diaphragmatic Hernia: Physiology and Therapeutic Implications"],"prefix":"10.1542","volume":"24","author":[{"given":"Sandy","family":"Johng","sequence":"first","affiliation":[{"name":"*Department of Pediatrics, Children\u2019s Hospital of Philadelphia and Perelman School of Medicine, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria V.","family":"Fraga","sequence":"additional","affiliation":[{"name":"*Department of Pediatrics, Children\u2019s Hospital of Philadelphia and Perelman School of Medicine, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Patel","sequence":"additional","affiliation":[{"name":"\u2020Department of Neonatology, Royal Hospital for Children, Glasgow, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Kipfmueller","sequence":"additional","affiliation":[{"name":"\u2021Department of Neonatology and Pediatric Intensive Care, Children\u2019s Hospital, University of Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijit","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"\u2020Department of Neonatology, Royal Hospital for Children, Glasgow, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shazia","family":"Bhombal","sequence":"additional","affiliation":[{"name":"\u00a7Department of Pediatrics, Emory University\/Children\u2019s Healthcare of Atlanta, Atlanta, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2023,11,1]]},"reference":[{"key":"2023110103103795800_B1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.annepidem.2020.11.007","article-title":"Prevalence and mortality in children with congenital diaphragmatic hernia: a multicountry study","volume":"56","author":"Politis","year":"2021","journal-title":"Ann Epidemiol"},{"issue":"11","key":"2023110103103795800_B2","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1016\/j.jpedsurg.2020.06.022","article-title":"Prevalence and risk factors for congenital diaphragmatic hernia: a global view","volume":"55","author":"Paoletti","year":"2020","journal-title":"J Pediatr Surg"},{"issue":"4","key":"2023110103103795800_B3","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1159\/000320622","article-title":"Standardized postnatal management of infants with congenital diaphragmatic hernia in Europe: the CDH EURO Consortium consensus","volume":"98","author":"Reiss","year":"2010","journal-title":"Neonatology"},{"issue":"1","key":"2023110103103795800_B4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000322694","article-title":"Actual outcome in infants with congenital diaphragmatic hernia: the role of a standardized postnatal treatment protocol","volume":"29","author":"van den Hout","year":"2011","journal-title":"Fetal Diagn Ther"},{"issue":"6","key":"2023110103103795800_B5","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.siny.2014.09.004","article-title":"The Congenital Diaphragmatic Hernia Study Group registry update","volume":"19","author":"Harting","year":"2014","journal-title":"Semin Fetal Neonatal Med"},{"key":"2023110103103795800_B6","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jpeds.2017.08.060","article-title":"Ventricular performance is associated with need for extracorporeal membrane oxygenation in newborns with congenital diaphragmatic hernia","volume":"191","author":"Altit","year":"2017","journal-title":"J Pediatr"},{"issue":"12","key":"2023110103103795800_B7","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1164\/rccm.201904-0731OC","article-title":"Ventricular dysfunction is a critical determinant of mortality in congenital diaphragmatic hernia","volume":"200","author":"Patel","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"2023110103103795800_B8","volume-title":"Les oeuvres de M. Ambroise Pare: Avec les figures & portraicts tant de l\u2019anatomie que des instruments de chirurgie, & de plusieurs monstres","author":"Par\u00e9","year":"1575"},{"key":"2023110103103795800_B9","first-page":"89","article-title":"Einige Betrachtungen uber die Entstehung des angebornen Zwerchfelbruches","volume":"19","author":"Bochdalek","year":"1848","journal-title":"Vierteljahrschr fd prak Heilk (Prag)"},{"issue":"2-3","key":"2023110103103795800_B10","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/BF01349971","article-title":"Historical aspects of congenital diaphragmatic hernia","volume":"12","author":"Puri","year":"1997","journal-title":"Pediatr Surg Int"},{"issue":"6","key":"2023110103103795800_B11","first-page":"579","article-title":"Congenital hernia of the diaphragm","volume":"71","author":"Gross","year":"1946","journal-title":"Am J Dis Child (1911)"},{"issue":"10","key":"2023110103103795800_B12","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/S0022-3468(05)80338-0","article-title":"Correction of congenital diaphragmatic hernia in utero: VI\u2013hard-earned lessons","volume":"28","author":"Harrison","year":"1993","journal-title":"J Pediatr Surg"},{"issue":"22","key":"2023110103103795800_B13","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1056\/NEJM199005313222207","article-title":"Successful repair in utero of a fetal diaphragmatic hernia after removal of herniated viscera from the left thorax","volume":"322","author":"Harrison","year":"1990","journal-title":"N Engl J Med"},{"issue":"12","key":"2023110103103795800_B14","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1111\/j.1651-2227.2009.01436.x","article-title":"Congenital diaphragmatic hernia: review of the literature in reflection of unresolved dilemmas","volume":"98","author":"Grisaru-Granovsky","year":"2009","journal-title":"Acta Paediatr"},{"issue":"5","key":"2023110103103795800_B15","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1067\/mob.2000.108871","article-title":"Treatment of severe congenital diaphragmatic hernia by fetal tracheal occlusion: clinical experience with fifteen cases","volume":"183","author":"Flake","year":"2000","journal-title":"Am J Obstet Gynecol"},{"issue":"10","key":"2023110103103795800_B16","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/S0022-3468(96)90824-6","article-title":"Correction of congenital diaphragmatic hernia in utero VIII: Response of the hypoplastic lung to tracheal occlusion","volume":"31","author":"Harrison","year":"1996","journal-title":"J Pediatr Surg"},{"issue":"2","key":"2023110103103795800_B17","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1056\/NEJMoa2026983","article-title":"Randomized trial of fetal surgery for moderate left diaphragmatic hernia","volume":"385","author":"Deprest","year":"2021","journal-title":"N Engl J Med"},{"issue":"2","key":"2023110103103795800_B18","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1056\/NEJMoa2027030","article-title":"Randomized trial of fetal surgery for severe left diaphragmatic hernia","volume":"385","author":"Deprest","year":"2021","journal-title":"N Engl J Med"},{"key":"2023110103103795800_B19","doi-asserted-by":"crossref","first-page":"808317","DOI":"10.3389\/fped.2021.808317","article-title":"Respiratory support of infants with congenital diaphragmatic hernia","volume":"9","author":"Williams","year":"2021","journal-title":"Front Pediatr"},{"issue":"5","key":"2023110103103795800_B20","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1097\/SLA.0000000000001533","article-title":"Conventional mechanical ventilation versus high-frequency oscillatory ventilation for congenital diaphragmatic hernia: a randomized clinical trial (The VICI-trial)","volume":"263","author":"Snoek","year":"2016","journal-title":"Ann Surg"},{"issue":"6","key":"2023110103103795800_B21","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1542\/peds.99.6.838","article-title":"Inhaled nitric oxide and hypoxic respiratory failure in infants with congenital diaphragmatic hernia","volume":"99","author":"The Neonatal Inhaled Nitric Oxide Study Group (NINOS)","year":"1997","journal-title":"Pediatrics"},{"issue":"7","key":"2023110103103795800_B22","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1038\/s41390-023-02491-8","article-title":"Early nitric oxide is not associated with improved outcomes in congenital diaphragmatic hernia","volume":"93","author":"Noh","year":"2023","journal-title":"Pediatr Res"},{"issue":"3","key":"2023110103103795800_B23","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0095-5108(18)30039-3","article-title":"Pulmonary vascular biology during neonatal transition","volume":"26","author":"Lakshminrusimha","year":"1999","journal-title":"Clin Perinatol"},{"issue":"5","key":"2023110103103795800_B24","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1159\/000501906","article-title":"The Transitional heart: from early embryonic and fetal development to neonatal life","volume":"47","author":"Tan","year":"2020","journal-title":"Fetal Diagn Ther"},{"issue":"6","key":"2023110103103795800_B25","doi-asserted-by":"crossref","first-page":"151229","DOI":"10.1016\/j.sempedsurg.2022.151229","article-title":"Embryology and anatomy of congenital diaphragmatic hernia","volume":"31","author":"De Leon","year":"2022","journal-title":"Semin Pediatr Surg"},{"key":"2023110103103795800_B26","doi-asserted-by":"crossref","first-page":"804496","DOI":"10.3389\/fped.2021.804496","article-title":"Cellular origin(s) of congenital diaphragmatic hernia","volume":"9","author":"Edel","year":"2021","journal-title":"Front Pediatr"},{"issue":"5","key":"2023110103103795800_B27","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/ng.3250","article-title":"Muscle connective tissue controls development of the diaphragm and is a source of congenital diaphragmatic hernias","volume":"47","author":"Merrell","year":"2015","journal-title":"Nat Genet"},{"issue":"6","key":"2023110103103795800_B28","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1002\/uog.6234","article-title":"Value of prenatal magnetic resonance imaging in the prediction of postnatal outcome in fetuses with diaphragmatic hernia","volume":"32","author":"Jani","year":"2008","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"1","key":"2023110103103795800_B29","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/uog.4052","article-title":"Observed to expected lung area to head circumference ratio in the prediction of survival in fetuses with isolated diaphragmatic hernia","volume":"30","author":"Jani","year":"2007","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"10","key":"2023110103103795800_B30","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1016\/j.ajpath.2016.07.006","article-title":"Polygenic causes of congenital diaphragmatic hernia produce common lung pathologies","volume":"186","author":"Donahoe","year":"2016","journal-title":"Am J Pathol"},{"issue":"5","key":"2023110103103795800_B31","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1055\/s-0032-1329409","article-title":"Etiological and pathogenic factors in congenital diaphragmatic hernia","volume":"22","author":"Sluiter","year":"2012","journal-title":"Eur J Pediatr Surg"},{"issue":"4","key":"2023110103103795800_B32","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/bdrc.21085","article-title":"Pulmonary vascular development goes awry in congenital lung abnormalities","volume":"102","author":"Kool","year":"2014","journal-title":"Birth Defects Res C Embryo Today"},{"issue":"3","key":"2023110103103795800_B33","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0022-3468(97)90587-X","article-title":"Pulmonary artery structural changes in pulmonary hypertension complicating congenital diaphragmatic hernia","volume":"32","author":"Yamataka","year":"1997","journal-title":"J Pediatr Surg"},{"issue":"1-2","key":"2023110103103795800_B34","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s003830050429","article-title":"Comparison of the pulmonary vasculature in newborns and stillborns with congenital diaphragmatic hernia","volume":"14","author":"Taira","year":"1998","journal-title":"Pediatr Surg Int"},{"issue":"1","key":"2023110103103795800_B35","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/path.1677","article-title":"Endothelin receptor expression in human lungs of newborns with congenital diaphragmatic hernia","volume":"205","author":"de Lagausie","year":"2005","journal-title":"J Pathol"},{"issue":"6","key":"2023110103103795800_B36","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1097\/SLA.0000000000001054","article-title":"Unique tracheal fluid microRNA signature predicts response to FETO in patients with congenital diaphragmatic hernia","volume":"262","author":"Pereira-Terra","year":"2015","journal-title":"Ann Surg"},{"issue":"5","key":"2023110103103795800_B37","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0022-3468(84)80105-0","article-title":"Left ventricular hypoplasia in congenital diaphragmatic hernia","volume":"19","author":"Siebert","year":"1984","journal-title":"J Pediatr Surg"},{"issue":"7","key":"2023110103103795800_B38","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1038\/s41372-021-00986-y","article-title":"Fetal cardiac dimensions in congenital diaphragmatic hernia: relationship with gestational age and postnatal outcomes","volume":"41","author":"Massolo","year":"2021","journal-title":"J Perinatol"},{"issue":"6","key":"2023110103103795800_B39","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1002\/uog.14790","article-title":"Severe left diaphragmatic hernia limits size of fetal left heart more than does right diaphragmatic hernia","volume":"46","author":"Byrne","year":"2015","journal-title":"Ultrasound Obstet Gynecol"},{"key":"2023110103103795800_B40","doi-asserted-by":"crossref","first-page":"1083370","DOI":"10.3389\/fped.2022.1083370","article-title":"Expected small left heart size in the presence of congenital diaphragmatic hernia: Fetal values and Z-scores for infants confirmed to have no heart disease postnatally","volume":"10","author":"Moon-Grady","year":"2022","journal-title":"Front Pediatr"},{"issue":"1","key":"2023110103103795800_B41","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0022-3476(98)70178-7","article-title":"Cardiac malposition, redistribution of fetal cardiac output, and left heart hypoplasia reduce survival in neonates with congenital diaphragmatic hernia requiring extracorporeal membrane oxygenation","volume":"133","author":"Baumgart","year":"1998","journal-title":"J Pediatr"},{"issue":"19","key":"2023110103103795800_B42","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1136\/hrt.2010.196550","article-title":"Preferential streaming of the ductus venosus and inferior caval vein towards the right heart is associated with left heart underdevelopment in human fetuses with left-sided diaphragmatic hernia","volume":"96","author":"Stressig","year":"2010","journal-title":"Heart"},{"key":"2023110103103795800_B43","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.yjmcc.2021.04.001","article-title":"Cardiac energy metabolism may play a fundamental role in congenital diaphragmatic hernia-associated ventricular dysfunction","volume":"157","author":"Zhaorigetu","year":"2021","journal-title":"J Mol Cell Cardiol"},{"issue":"2","key":"2023110103103795800_B44","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1152\/japplphysiol.00760.2018","article-title":"Effect of lung hypoplasia on the cardiorespiratory transition in newborn lambs","volume":"127","author":"McGillick","year":"2019","journal-title":"J Appl Physiol (1985)"},{"issue":"6","key":"2023110103103795800_B45","doi-asserted-by":"crossref","first-page":"F617","DOI":"10.1136\/archdischild-2018-316045","article-title":"Neonatal cardiopulmonary transition in an ovine model of congenital diaphragmatic hernia","volume":"104","author":"Kashyap","year":"2019","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"3","key":"2023110103103795800_B46","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/pr.2017.91","article-title":"Lung hypoplasia in newborn rabbits with a diaphragmatic hernia affects pulmonary ventilation but not perfusion","volume":"82","author":"Flemmer","year":"2017","journal-title":"Pediatr Res"},{"issue":"2","key":"2023110103103795800_B47","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/s41372-018-0269-6","article-title":"Lowest PaCO2 on the first day of life predicts mortality and morbidity among infants with congenital diaphragmatic hernia","volume":"39","author":"Patel","year":"2019","journal-title":"J Perinatol"},{"issue":"3","key":"2023110103103795800_B48","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1136\/archdischild-2019-317477","article-title":"Initiating resuscitation before umbilical cord clamping in infants with congenital diaphragmatic hernia: a pilot feasibility trial","volume":"105","author":"Foglia","year":"2020","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2023110103103795800_B49","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jpeds.2019.12.037","article-title":"Implications of atrial-level shunting by echocardiography in newborns with congenital diaphragmatic hernia","volume":"219","author":"Wehrmann","year":"2020","journal-title":"J Pediatr"},{"issue":"2","key":"2023110103103795800_B50","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1159\/000512966","article-title":"Early, postnatal pulmonary hypertension severity predicts inpatient outcomes in congenital diaphragmatic hernia","volume":"118","author":"Ferguson","year":"2021","journal-title":"Neonatology"},{"issue":"12","key":"2023110103103795800_B51","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/jp.2012.18","article-title":"Does a highest pre-ductal O(2) saturation &lt;85% predict non-survival for congenital diaphragmatic hernia?","volume":"32","author":"Yoder","year":"2012","journal-title":"J Perinatol"},{"issue":"2","key":"2023110103103795800_B52","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jpeds.2014.10.024","article-title":"Persistence of pulmonary hypertension by echocardiography predicts short-term outcomes in congenital diaphragmatic hernia","volume":"166","author":"Lusk","year":"2015","journal-title":"J Pediatr"},{"issue":"1","key":"2023110103103795800_B53","doi-asserted-by":"crossref","first-page":"151168","DOI":"10.1053\/j.semperi.2019.07.007","article-title":"Congenital diaphragmatic hernia-associated cardiac dysfunction","volume":"44","author":"Patel","year":"2020","journal-title":"Semin Perinatol"},{"issue":"1","key":"2023110103103795800_B54","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/PCC.0b013e31829b1e7a","article-title":"Right ventricular diastolic function measured by tissue Doppler imaging predicts early outcome in congenital diaphragmatic hernia","volume":"15","author":"Moenkemeyer","year":"2014","journal-title":"Pediatr Crit Care Med"},{"issue":"3","key":"2023110103103795800_B55","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1053\/j.sempedsurg.2017.04.001","article-title":"Cardiac dysfunction in congenital diaphragmatic hernia: pathophysiology, clinical assessment, and management","volume":"26","author":"Patel","year":"2017","journal-title":"Semin Pediatr Surg"},{"key":"2023110103103795800_B56","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.jpeds.2018.07.062","article-title":"Early postnatal ventricular dysfunction is associated with disease severity in patients with congenital diaphragmatic hernia","volume":"203","author":"Patel","year":"2018","journal-title":"J Pediatr"},{"key":"2023110103103795800_B57","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s40748-017-0045-1","article-title":"Congenital diaphragmatic hernia - a review","volume":"3","author":"Chandrasekharan","year":"2017","journal-title":"Matern Health Neonatol Perinatol"},{"issue":"3","key":"2023110103103795800_B58","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1164\/rccm.202212-2306LE","article-title":"Early postnatal ventricular disproportion predicts outcome in congenital diaphragmatic hernia","volume":"208","author":"Pugnaloni","year":"2023","journal-title":"Am J Respir Crit Care Med"},{"issue":"7","key":"2023110103103795800_B59","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1097\/PCC.0000000000002318","article-title":"Early left ventricular dysfunction and severe pulmonary hypertension predict adverse outcomes in \u201clow-risk\u201d congenital diaphragmatic hernia","volume":"21","author":"Dao","year":"2020","journal-title":"Pediatr Crit Care Med"},{"issue":"13","key":"2023110103103795800_B60","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.jacc.2018.06.074","article-title":"Positive pressure ventilation in the cardiac intensive care unit","volume":"72","author":"Alviar","year":"2018","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"2023110103103795800_B61","doi-asserted-by":"crossref","first-page":"e20201258","DOI":"10.1542\/peds.2020-1258","article-title":"Routine intubation in newborns with congenital diaphragmatic hernia","volume":"146","author":"Cochius-den Otter","year":"2020","journal-title":"Pediatrics"},{"issue":"4","key":"2023110103103795800_B62","doi-asserted-by":"crossref","first-page":"E103","DOI":"10.1503\/cmaj.170206","article-title":"Diagnosis and management of congenital diaphragmatic hernia: a clinical practice guideline","volume":"190","author":"Puligandla","year":"2018","journal-title":"CMAJ"},{"issue":"1","key":"2023110103103795800_B63","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1159\/000444210","article-title":"Standardized postnatal management of infants with congenital diaphragmatic hernia in Europe: The CDH EURO Consortium Consensus - 2015 Update","volume":"110","author":"Snoek","year":"2016","journal-title":"Neonatology"},{"issue":"5","key":"2023110103103795800_B64","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1152\/jappl.1982.53.5.1110","article-title":"Effect of lung inflation on pulmonary vascular resistance by arterial and venous occlusion","volume":"53","author":"Hakim","year":"1982","journal-title":"J Appl Physiol"},{"issue":"2, Part B","key":"2023110103103795800_B65","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ppedcard.2015.10.017","article-title":"Cardiopulmonary interactions in adults and children with congenital heart disease","volume":"39","author":"Iliopoulos","year":"2015","journal-title":"Prog Pediatr Cardiol"},{"issue":"2","key":"2023110103103795800_B66","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1177\/0885066602250369","article-title":"Hemodynamic consequences of heart-lung interactions","volume":"18","author":"Steingrub","year":"2003","journal-title":"J Intensive Care Med"},{"key":"2023110103103795800_B67","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jpeds.2018.04.027","article-title":"Lower distending pressure improves respiratory mechanics in congenital diaphragmatic hernia complicated by persistent pulmonary hypertension","volume":"200","author":"Guevorkian","year":"2018","journal-title":"J Pediatr"},{"issue":"4","key":"2023110103103795800_B68","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1164\/rccm.201607-1370LE","article-title":"Individualized multiplanar electrical impedance tomography in infants to optimize lung monitoring","volume":"195","author":"Miedema","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"2023110103103795800_B69","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1053\/j.sempedsurg.2007.01.006","article-title":"Mechanical ventilation strategies in the management of congenital diaphragmatic hernia","volume":"16","author":"Logan","year":"2007","journal-title":"Semin Pediatr Surg"},{"issue":"2","key":"2023110103103795800_B70","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1542\/peds.101.2.289","article-title":"Lung volume, pulmonary vasculature, and factors affecting survival in congenital diaphragmatic hernia","volume":"101","author":"Thibeault","year":"1998","journal-title":"Pediatrics"},{"issue":"9","key":"2023110103103795800_B71","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/0022-3468(91)90666-H","article-title":"Congenital diaphragmatic hernia, extracorporeal membrane oxygenation, and death: a spectrum of etiologies","volume":"26","author":"Price","year":"1991","journal-title":"J Pediatr Surg"},{"issue":"12","key":"2023110103103795800_B72","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1016\/S0022-3468(99)90319-6","article-title":"Pulmonary barotrauma in congenital diaphragmatic hernia: a clinicopathological correlation","volume":"34","author":"Sakurai","year":"1999","journal-title":"J Pediatr Surg"},{"issue":"1","key":"2023110103103795800_B73","first-page":"CD000399","article-title":"Nitric oxide for respiratory failure in infants born at or near term","volume":"1","author":"Barrington","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"2023110103103795800_B74","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jpeds.2019.09.052","article-title":"Inhaled nitric oxide is associated with improved oxygenation in a subpopulation of infants with congenital diaphragmatic hernia and pulmonary hypertension","volume":"219","author":"Lawrence","year":"2020","journal-title":"J Pediatr"},{"issue":"2","key":"2023110103103795800_B75","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1053\/j.semperi.2005.04.008","article-title":"Pulmonary vasodilator therapy in congenital diaphragmatic hernia: acute, late, and chronic pulmonary hypertension","volume":"29","author":"Kinsella","year":"2005","journal-title":"Semin Perinatol"},{"issue":"1","key":"2023110103103795800_B76","doi-asserted-by":"crossref","first-page":"151167","DOI":"10.1053\/j.semperi.2019.07.006","article-title":"Congenital diaphragmatic hernia-associated pulmonary hypertension","volume":"44","author":"Gupta","year":"2020","journal-title":"Semin Perinatol"},{"key":"2023110103103795800_B77","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jpeds.2018.04.052","article-title":"Treprostinil improves persistent pulmonary hypertension associated with congenital diaphragmatic hernia","volume":"200","author":"Lawrence","year":"2018","journal-title":"J Pediatr"},{"issue":"3","key":"2023110103103795800_B78","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1053\/j.semperi.2015.12.004","article-title":"Pharmacologic strategies in neonatal pulmonary hypertension other than nitric oxide","volume":"40","author":"Lakshminrusimha","year":"2016","journal-title":"Semin Perinatol"},{"issue":"4","key":"2023110103103795800_B79","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1002\/ppul.23935","article-title":"Continuous intravenous sildenafil as an early treatment in neonates with congenital diaphragmatic hernia","volume":"53","author":"Kipfmueller","year":"2018","journal-title":"Pediatr Pulmonol"},{"issue":"2","key":"2023110103103795800_B80","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1038\/jp.2016.46","article-title":"Management of pulmonary hypertension in infants with congenital diaphragmatic hernia","volume":"36","author":"Gien","year":"2016","journal-title":"J Perinatol"},{"issue":"1","key":"2023110103103795800_B81","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jpedsurg.2018.10.039","article-title":"Use of prostaglandin E1 to treat pulmonary hypertension in congenital diaphragmatic hernia","volume":"54","author":"Lawrence","year":"2019","journal-title":"J Pediatr Surg"},{"issue":"21","key":"2023110103103795800_B82","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1161\/CIR.0000000000000329","article-title":"Pediatric pulmonary hypertension","volume":"132","author":"Abman","year":"2015","journal-title":"Circulation"},{"issue":"1","key":"2023110103103795800_B83","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40748-017-0066-9","article-title":"Milrinone in congenital diaphragmatic hernia: a randomized pilot trial: study protocol, review of literature and survey of current practices","volume":"3","author":"Lakshminrusimha","year":"2017","journal-title":"Matern Health Neonatol Perinatol"},{"issue":"7","key":"2023110103103795800_B84","doi-asserted-by":"crossref","first-page":"e382","DOI":"10.1097\/PCC.0000000000002665","article-title":"Exploratory assessment of levosimendan in infants with congenital diaphragmatic hernia","volume":"22","author":"Schroeder","year":"2021","journal-title":"Pediatr Crit Care Med"},{"key":"2023110103103795800_B85","doi-asserted-by":"crossref","first-page":"ii57","DOI":"10.1136\/heartjnl-2015-307774","article-title":"Pulmonary hypertension in the intensive care unit. Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and DGPK","volume":"102","author":"Kaestner","year":"2016","journal-title":"Heart"},{"key":"2023110103103795800_B86","doi-asserted-by":"crossref","first-page":"1104728","DOI":"10.3389\/fped.2023.1104728","article-title":"Early vasopressin infusion improves oxygenation in infants with congenital diaphragmatic hernia","volume":"11","author":"Capolupo","year":"2023","journal-title":"Front Pediatr"},{"key":"2023110103103795800_B87","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jpeds.2022.03.022","article-title":"Dopamine and neonatal pulmonary hypertension: pressing need for a better pressor?","volume":"246","author":"McNamara","year":"2022","journal-title":"J Pediatr"},{"issue":"1","key":"2023110103103795800_B88","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jpeds.2014.03.059","article-title":"Vasopressin improves hemodynamic status in infants with congenital diaphragmatic hernia","volume":"165","author":"Acker","year":"2014","journal-title":"J Pediatr"},{"issue":"9","key":"2023110103103795800_B89","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1038\/s41372-022-01397-3","article-title":"Improved survival for infants with severe congenital diaphragmatic hernia","volume":"42","author":"Gien","year":"2022","journal-title":"J Perinatol"},{"issue":"3","key":"2023110103103795800_B90","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.clp.2012.06.006","article-title":"The pulmonary circulation in neonatal respiratory failure","volume":"39","author":"Lakshminrusimha","year":"2012","journal-title":"Clin Perinatol"},{"issue":"2","key":"2023110103103795800_B91","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/MAT.0000000000001338","article-title":"Management of congenital diaphragmatic hernia treated with extracorporeal life support: interim guidelines consensus statement from the Extracorporeal Life Support Organization","volume":"67","author":"Guner","year":"2021","journal-title":"ASAIO J"}],"container-title":["NeoReviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/neoreviews\/article-pdf\/24\/11\/e720\/1547516\/neoreviews.052023rev00094.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/neoreviews\/article-pdf\/24\/11\/e720\/1547516\/neoreviews.052023rev00094.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T03:11:47Z","timestamp":1698808307000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/neoreviews\/article\/24\/11\/e720\/194501\/Unique-Cardiopulmonary-Interactions-in-Congenital"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,1]]},"references-count":91,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,11,1]]},"published-print":{"date-parts":[[2023,11,1]]}},"URL":"https:\/\/doi.org\/10.1542\/neo.24-11-e720","relation":{},"ISSN":["1526-9906"],"issn-type":[{"value":"1526-9906","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,1]]}}}