{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T06:01:49Z","timestamp":1771480909686,"version":"3.50.1"},"reference-count":35,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:sec>\n                  <jats:title\/>\n                  <jats:p>See Bonus NeoBriefs videos and downloadable teaching slides<\/jats:p>\n                  <jats:p>Metabolic acidosis can manifest in the neonatal period and cause significant morbidity and mortality in neonates. Preterm infants are at an even higher risk of developing metabolic acidosis. If the acidosis results from a dysfunction of acid-base homeostasis by the renal system, the disorder is known as renal tubular acidosis (RTA). In this review, we will describe renal development and normal acid-base homeostasis by the renal system. We will also discuss the pathophysiology of the different types of RTA, laboratory findings to aid in diagnosis, and treatment considerations. Understanding RTA will help neonatal clinicians recognize and diagnose an infant affected by RTA and initiate treatment in a timely manner.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/neo.25-2-e99","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T03:07:30Z","timestamp":1706756850000},"page":"e99-e106","source":"Crossref","is-referenced-by-count":2,"title":["Renal Tubular Acidosis in the Neonate"],"prefix":"10.1542","volume":"25","author":[{"given":"Brian R.","family":"Lee","sequence":"first","affiliation":[{"name":"*Department of Neonatology, Southern California Permanente Medical Group, Pasadena, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2024,2,1]]},"reference":[{"issue":"12","key":"2024020714080943700_B1","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.2215\/CJN.07400715","article-title":"Acid-base homeostasis","volume":"10","author":"Hamm","year":"2015","journal-title":"Clin J Am Soc Nephrol"},{"issue":"2","key":"2024020714080943700_B2","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00467-018-4142-9","article-title":"Renal aspects of metabolic acid-base disorders in neonates","volume":"35","author":"Iacobelli","year":"2020","journal-title":"Pediatr Nephrol"},{"issue":"9","key":"2024020714080943700_B3","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1681\/ASN.2006060620","article-title":"Acid-base transport by the renal proximal tubule","volume":"17","author":"Boron","year":"2006","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"2024020714080943700_B4","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2174\/138920209787581262","article-title":"Molecular pathophysiology of renal tubular acidosis","volume":"10","author":"Pereira","year":"2009","journal-title":"Curr Genomics"},{"issue":"6","key":"2024020714080943700_B5","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.biocel.2005.01.002","article-title":"Renal tubular acidosis: developments in our understanding of the molecular basis","volume":"37","author":"Laing","year":"2005","journal-title":"Int J Biochem Cell Biol"},{"issue":"7","key":"2024020714080943700_B6","doi-asserted-by":"crossref","first-page":"F658","DOI":"10.1152\/ajprenal.00219.2015","article-title":"NBCe1 expression is required for normal renal ammonia metabolism","volume":"309","author":"Handlogten","year":"2015","journal-title":"Am J Physiol Renal Physiol"},{"issue":"2","key":"2024020714080943700_B7","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s12325-020-01587-5","article-title":"Renal tubular acidosis and management strategies: a narrative review","volume":"38","author":"Palmer","year":"2021","journal-title":"Adv Ther"},{"issue":"1","key":"2024020714080943700_B8","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/cphy.c120010","article-title":"Renal ammonia metabolism and transport","volume":"3","author":"Weiner","year":"2013","journal-title":"Compr Physiol"},{"key":"2024020714080943700_B9","volume-title":"Fanaroff and Martin\u2019s Neonatal-Perinatal Medicine","author":"Martin","year":"2019","edition":"11th ed."},{"key":"2024020714080943700_B10","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ebiom.2017.12.016","article-title":"Development of the human fetal kidney from mid to late gestation in male and female infants","volume":"27","author":"Ryan","year":"2018","journal-title":"EBioMedicine"},{"issue":"2","key":"2024020714080943700_B11","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/MOP.0000000000000325","article-title":"Neonatal nephrology","volume":"28","author":"Baum","year":"2016","journal-title":"Curr Opin Pediatr"},{"issue":"4","key":"2024020714080943700_B12","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.bbrc.2009.03.062","article-title":"Southeast Asian AE1 associated renal tubular acidosis: cation leak is a class effect","volume":"382","author":"Walsh","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"2024020714080943700_B13","unstructured":"Alexander\u2008RT, Law\u2008L, Gil-Pe\u00f1a\u2008H, Greenbaum\u2008L, Santos\u2008F. 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