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We aim to describe several historical immunization moments and analyze them using the vaccine hesitancy framework of the \u201c5Cs\u201d (ie, confidence, complacency, constraints, risk calculation, and collective responsibility).<\/jats:p>","DOI":"10.1542\/neo.25-3-e187","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T03:00:40Z","timestamp":1711940440000},"page":"e187-e192","source":"Crossref","is-referenced-by-count":0,"title":["From Cotton Mather to Dr Fauci: Historical Markers of Vaccine Hesitancy"],"prefix":"10.1542","volume":"25","author":[{"given":"Destri","family":"Eichman","sequence":"first","affiliation":[{"name":"*School of Medicine, University of Missouri-Columbia, Columbia, MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana","family":"Bichianu","sequence":"additional","affiliation":[{"name":"\u2020Department of Pediatrics, University of Missouri-Columbia, Columbia, MO"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2024,4,1]]},"reference":[{"key":"2024040103003700000_B1","unstructured":"Centers for Disease Control and Prevention (CDC). 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