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This shift results from increased postnatal intervention due to shared decision-making with families and medical teams. This review summarizes the clinical manifestations of trisomy 18 syndrome but also explores the updated long-term outcomes and subsequent guidance for future medical surveillance in a population of newborns previously expected to die before their first birthday.<\/jats:p>","DOI":"10.1542\/neo.26-12-082","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:03:57Z","timestamp":1764547437000},"page":"e820-e834","source":"Crossref","is-referenced-by-count":3,"title":["Updates in Trisomy 18"],"prefix":"10.1542","volume":"26","author":[{"given":"Keerthana","family":"Srinivasan","sequence":"first","affiliation":[{"name":"1Division of Neonatology, Department of Pediatrics, Harbor-UCLA, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Canarte","sequence":"additional","affiliation":[{"name":"1Division of Neonatology, Department of Pediatrics, Harbor-UCLA, Los Angeles, 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