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While vertical transmission mechanisms vary among arboviruses, inflammation, placental disruption, and viral replication within fetal tissues are common pathological features. Early diagnosis is complicated by overlapping clinical symptoms, limited laboratory capacity in endemic areas, and cross-reactivity in serological tests for flaviviruses. In this review, we highlight the need for improved surveillance, targeted diagnostics, and preventive strategies, including vector control and maternal vaccination, to reduce the burden of congenital arboviral diseases. Understanding the maternal-fetal dynamics of arboviral infections is essential for developing effective public health interventions and mitigating long-term outcomes in affected populations.<\/jats:p>","DOI":"10.1542\/neo.27-10-053","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:04:30Z","timestamp":1790813070000},"page":"e611-e625","source":"Crossref","is-referenced-by-count":0,"title":["Congenital Arboviruses: A Review"],"prefix":"10.1542","volume":"27","author":[{"given":"Neema","family":"Pithia","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics, University of California, Los Angeles, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Nielsen-Saines","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics, University of California, Los Angeles, Los Angeles, 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