{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:38:57Z","timestamp":1784194737356,"version":"3.55.0"},"reference-count":28,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,7,1]]},"abstract":"<jats:p>Background.\u2003Much of what is known about human monocytic ehrlichiosis (HME) is based upon studies with adult patients.<\/jats:p><jats:p>Purpose.\u2003To review our experience with HME to better understand the epidemiology, clinical manifestations, and outcome of this disease in children.<\/jats:p><jats:p>Methods.\u2003Demographic, clinical, and laboratory data were gathered after review of the medical records of patients identified with HME.<\/jats:p><jats:p>Results.\u2003Twelve patients with an median age of 7.4 years (range, 7 months to 13.7 years) were identified with HME; 10 were white, 7 were male, and 10 were from hometowns of &amp;lt;800 people. Eight patients presented from May through July, and 8 had a history of tick bites. Symptoms demonstrated by the patients during their illness included fever (100%), rash (67%), myalgias (58%), and vomiting, diarrhea, and headache (25%). On presentation, patients demonstrated thrombocytopenia (92%), elevated liver function tests (91%), lymphopenia (75%), hyponatremia (67%), leukopenia (58%), and anemia (42%) on the initial laboratory examination. Four patients presented in shock and 3 required blood pressure support and mechanical ventilation for a median of 10 days (8 to 37 days). These complicated patients required longer hospitalization (19.5 days vs 5.5 days) and attained higher blood urea nitrogen levels (42.5 mg\/dL vs 10 mg\/dL) than the patients not presenting with shock. Morbidity associated with HME patients included a decrease in cognitive and neurologic performance.<\/jats:p><jats:p>Conclusions.\u2003More information and long-term follow-up is required to understand the full spectrum of disease and morbidity associated with HME in children.<\/jats:p>","DOI":"10.1542\/peds.100.1.e10","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T23:40:17Z","timestamp":1092440417000},"page":"e10-e10","source":"Crossref","is-referenced-by-count":43,"title":["Human Monocytic Ehrlichiosis in Children"],"prefix":"10.1542","volume":"100","author":[{"given":"Gordon E.","family":"Schutze","sequence":"first","affiliation":[{"name":"1From the Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children's Hospital, Little Rock, Arkansas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard F.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"1From the Department of 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