{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T10:00:41Z","timestamp":1790848841710,"version":"4.1.0"},"reference-count":26,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,8,1]]},"abstract":"<jats:p>Purpose.\u2003To report the outcomes of the 58 hemispherectomies performed at Johns Hopkins between 1968 and January 1996.<\/jats:p>\n               <jats:p>Methods.\u2003Charts were reviewed of the 58 hemispherectomies performed at Johns Hopkins Medical Institutions by the Pediatric Epilepsy Group during the years 1968 to 1996. Twenty-seven operations were done for Rasmussen's syndrome, 24 operations for cortical dysplasias\/hemimegalencephalies, and 7 for Sturge-Weber syndrome or other congenital vascular problems. Seizure control alone did not seem to adequately describe the outcomes of the procedure. Therefore, a score was constructed that included seizure frequency, motor disability, and intellectual handicap. This burden of illness score better described the child's handicap before and after surgery.<\/jats:p>\n               <jats:p>Results.\u2003Perioperative death occurred in 4 out of 58 children. Of the 54 surviving children, 54% (29\/54) are seizure-free, 24% (13\/54) have nonhandicapping seizures, and 23% (12\/54) have residual seizures that interfere to some extent with function. Reduction in seizures was related to the etiology of the unilateral epilepsy. Eighty-nine percent of children with Rasmussen's, 67% of those with dysplasias, and 67% of the vascular group are seizure-free, or have occasional, nonhandicapping seizures. All operations were considered by the parents and the physicians to have been successful in decreasing the burden of illness. In 44 the procedure was very successful, in 7 it was moderately successful, and in 3 it was minimally successful. Success was related to the etiology, and early surgery was preferable.<\/jats:p>\n               <jats:p>Conclusion.\u2003Hemispherectomy can be a valuable procedure for relieving the burden of seizures, the burden of medication, and the general dysfunction in children with severe or progressive unilateral cortical disease. Early hemispherectomy, although increasing the hemiparesis in children with Rasmussen's syndrome, relieves the burden of constant seizures and allows the child to return to a more normal life. In children with dysplasias, early surgery can allow the resumption of more normal development.<\/jats:p>","DOI":"10.1542\/peds.100.2.163","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T23:40:17Z","timestamp":1092440417000},"page":"163-171","source":"Crossref","is-referenced-by-count":212,"title":["Why Would You Remove Half a Brain? The Outcome of 58 Children After Hemispherectomy\u2014The Johns Hopkins Experience: 1968 to 1996"],"prefix":"10.1542","volume":"100","author":[{"given":"Eileen P.\u2009G.","family":"Vining","sequence":"first","affiliation":[{"name":"From the Pediatric Epilepsy Center, and the Departments of"},{"name":"Neurology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Freeman","sequence":"additional","affiliation":[{"name":"From the Pediatric Epilepsy Center, and the Departments of"},{"name":"Neurology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana J.","family":"Pillas","sequence":"additional","affiliation":[{"name":"From the Pediatric Epilepsy Center, and the Departments of"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumio","family":"Uematsu","sequence":"additional","affiliation":[{"name":"Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin 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