{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:59:44Z","timestamp":1791118784406,"version":"4.1.0"},"reference-count":25,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,9,1]]},"abstract":"<jats:p>Background.\u2003Apnea of prematurity remains among the most commonly diagnosed conditions in the Newborn Intensive Care Unit and may prolong hospital stays in some infants. Because survival of extremely premature infants has improved markedly, the natural history of apnea in this population needs to be reassessed.<\/jats:p>\n               <jats:p>Objective.\u2003To document the natural history of recurrent apnea and\/or bradycardia events in infants delivered at 24 to 28 weeks' gestation.<\/jats:p>\n               <jats:p>Methods.\u2003Medical records of all infants delivered at 24 to 28 weeks' gestation admitted to the Brigham and Women's Hospital Newborn Intensive Care Unit between January 1989 and March 1994 were reviewed to document the clinical course of apnea of prematurity. Subjects were included in the study sample if they were discharged home from the Brigham and Women's Hospital or after transfer to an affiliated hospital. Recordings of apnea and\/or bradycardia events were based on nursing observations of monitor alarms and assessment of the infant's condition.<\/jats:p>\n               <jats:p>Results.\u2003Of 457 eligible infants, 226 were included in the study sample and stratified by gestational age at birth assigned by the attending neonatologist. The time to resolution of recurrent apnea\/bradycardia events was longer with lower gestational age at birth. Apnea\/bradycardia events were frequently observed beyond 36 weeks' postconceptional age in all gestational age groups. The incidence of apnea persisting beyond 38 weeks postconceptional age was significantly higher in the 24- to 27-week infants combined compared with the 28-week infants.<\/jats:p>\n               <jats:p>Conclusions.\u2003Apnea of prematurity frequently persists beyond term gestation in infants delivered at 24 to 28 weeks' gestational age. These persistent apnea and\/or bradycardia events may contribute to prolonged hospitalization. Programs to promote earlier discharge of premature infants should take into account the variability in resolution of apnea and specifically address management of persistent apnea.<\/jats:p>","DOI":"10.1542\/peds.100.3.354","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T23:40:17Z","timestamp":1092440417000},"page":"354-359","source":"Crossref","is-referenced-by-count":207,"title":["Apnea Frequently Persists Beyond Term Gestation in Infants Delivered at 24 to 28 Weeks"],"prefix":"10.1542","volume":"100","author":[{"given":"Eric C.","family":"Eichenwald","sequence":"first","affiliation":[{"name":"Brigham and Women's Hospital; and the"},{"name":"Joint Program in Neonatology, Boston, Massachusetts."},{"name":"From the Department of Pediatrics, Harvard Medical School;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abimbola","family":"Aina","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, Harvard Medical School;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann R.","family":"Stark","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital; and the"},{"name":"Joint Program in Neonatology, Boston, Massachusetts."},{"name":"From the Department of Pediatrics, Harvard Medical School;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[1997,9,1]]},"reference":[{"key":"2021121105170556500_B1"},{"key":"2021121105170556500_B2","first-page":"547","article-title":"Home monitor follow-up of persistent apnea and bradycardia in preterm infants.","volume":"140","author":"Rosen","year":"1986","journal-title":"Am J Dis Child."},{"key":"2021121105170556500_B3","first-page":"273","article-title":"The effect of gestational age on the incidence and duration of recurrent apnoea in newborn babies.","volume":"17","author":"Henderson-Smart","year":"1981","journal-title":"Aust Paediatr J."},{"key":"2021121105170556500_B4","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0022-3476(86)80685-0","article-title":"Pathogenesis of apnea in preterm infants.","volume":"109","author":"Martin","year":"1986","journal-title":"J Pediatr."},{"key":"2021121105170556500_B5","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1164\/ajrccm\/137.1.113","article-title":"Prolonged apnea associated with upper airway protective reflexes in apnea of prematurity.","volume":"137","author":"Pickens","year":"1988","journal-title":"Am Rev Respir Dis."},{"key":"2021121105170556500_B6","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1542\/peds.50.2.219","article-title":"Periodic breathing and apnea in preterm infants. 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Lung function and regulation of breathing.","volume":"74","author":"Gerhardt","year":"1984","journal-title":"Pediatrics."},{"key":"2021121105170556500_B8","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/S0022-3476(82)80529-5","article-title":"Pharyngeal airway obstruction in preterm infants during mixed and obstructive apnea.","volume":"100","author":"Mathew","year":"1982","journal-title":"J Pediatr."},{"key":"2021121105170556500_B9","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0022-3476(79)80843-4","article-title":"Spontaneous neck flexion and airway obstruction during apneic spells in preterm infants.","volume":"94","author":"Thach","year":"1979","journal-title":"J Pediatr."},{"key":"2021121105170556500_B10","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1136\/adc.55.1.22","article-title":"Upper airways obstruction and apnoea in preterm babies.","volume":"55","author":"Milner","year":"1980","journal-title":"Arch Dis Child."},{"key":"2021121105170556500_B11","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1542\/peds.60.5.742","article-title":"Apnea monitor failure in infants with upper airway obstruction.","volume":"60","author":"Warburton","year":"1977","journal-title":"Pediatrics."},{"key":"2021121105170556500_B12","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1542\/peds.95.6.860","article-title":"Prolonged episodes of hypoxemia in preterm infants undetectable by cardiorespiratory monitors.","volume":"95","author":"Poets","year":"1995","journal-title":"Pediatrics."},{"key":"2021121105170556500_B13","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1542\/peds.58.4.494","article-title":"Bradycardia in preterm infants. 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