{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:14:49Z","timestamp":1787022889362,"version":"build-2736575974"},"reference-count":17,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,9,1]]},"abstract":"<jats:p>Objective.\u2003Blue light phototherapy is commonly administered to neonates as treatment of indirect hyperbilirubinemia, often in conjunction with blood transfusions to treat hemolytic anemia. We observed a distinctive cutaneous complication of phototherapy in six neonates with hyperbilirubinemia.<\/jats:p>\n                  <jats:p>Methodology.\u2003We studied the clinical and histologic characteristics of the eruption, as well as the porphyrin levels in affected neonates. Five of the patients had erythroblastosis fetalis; the other had profound anemia from twin\u2013twin transfusion. All of the neonates developed purpuric patches at sites of maximal exposure to the phototherapy lights, with dramatic sparing at shielded sites within 24 hours after initiation of the phototherapy. On discontinuation of phototherapy, all eruptions cleared within 1 week. Examination of skin biopsy sections showed purpura without significant inflammation or keratinocyte necrosis. Plasma porphyrins (copro- and proto-) were elevated in the two patients in which they were assessed.<\/jats:p>\n                  <jats:p>Conclusions.\u2003The distribution of the eruption in areas exposed to light and presence of circulating porphyrins suggest that porphyrinemia may underlie the light-induced purpuric eruption. Additional studies will be required to determine definitively the mechanisms of both the purpuric phototherapy-induced eruption and the development of increased blood porphyrin levels in these transfused neonates.<\/jats:p>","DOI":"10.1542\/peds.100.3.360","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T19:40:17Z","timestamp":1092426017000},"page":"360-364","source":"Crossref","is-referenced-by-count":40,"title":["Purpuric Phototherapy-induced Eruption in Transfused Neonates: Relation to Transient Porphyrinemia"],"prefix":"10.1542","volume":"100","author":[{"given":"Amy S.","family":"Paller","sequence":"first","affiliation":[{"name":"From the Departments of Pediatrics and"},{"name":"Dermatology, Northwestern University Medical School, Chicago, Illinois; and the"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne R.","family":"Eramo","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatrics and"},{"name":"Dermatology, Northwestern University Medical School, Chicago, Illinois; and the"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine E.","family":"Farrell","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatrics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietra D.","family":"Millard","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatrics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Honig","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bari B.","family":"Cunningham","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatrics and"},{"name":"Dermatology, Northwestern University Medical School, Chicago, Illinois; and the"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[1997,9,1]]},"reference":[{"key":"2021121111354697300_B1","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/S0190-9622(89)70141-9","article-title":"Dermal hematopoiesis in neonates: report of five cases.","volume":"20","author":"Bowden","year":"1989","journal-title":"J Am Acad Dermatol."},{"key":"2021121111354697300_B2","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/clinchem\/27.3.397","article-title":"Liquid chromatographic analysis for urinary porphyrins.","volume":"27","author":"Ford","year":"1981","journal-title":"Clin Chem."},{"key":"2021121111354697300_B3"},{"key":"2021121111354697300_B4","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1159\/000243298","article-title":"Management of neonatal hyperbilirubinemia: rational use of phototherapy.","volume":"58(suppl 1)","author":"Polin","year":"1990","journal-title":"Biol 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