{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T14:04:32Z","timestamp":1776261872197,"version":"3.50.1"},"reference-count":25,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,10,1]]},"abstract":"<jats:p>Objective.\u2003To establish the prevalence of endocrinologic disorders in children with neurofibromatosis type 1 (NF1) and the relationship between these disorders and cerebral abnormalities on magnetic resonance imaging.<\/jats:p>\n               <jats:p>Design.\u2003A prospective follow-up study.<\/jats:p>\n               <jats:p>Setting.\u2003A multidisciplinary neurofibromatosis clinic.<\/jats:p>\n               <jats:p>Patients.\u2003A total of 122 children diagnosed with NF1 according to diagnostic criteria set by the National Institutes of Health.<\/jats:p>\n               <jats:p>Results.\u2003Central precocious puberty (CPP) was diagnosed in 3 children and growth hormone deficiency (GHD) in 3 children. Optic pathway gliomas were observed in 15 children; in 9 of the 15 cases, the optic chiasm was involved. Of the 3 children with CPP, only 1 showed a chiasma glioma on magnetic resonance imaging. In 1 case with GHD, an optic chiasm glioma was detected on neuroimaging. Two of the 9 children with an optic chiasm glioma presented with CPP or GHD.<\/jats:p>\n               <jats:p>Conclusions.\u2003It has been suggested that CPP in children with NF1 is found exclusively in the presence of a chiasma glioma. We conclude that chiasma glioma may not be obligatory in children with NF1 and CPP or GHD. Moreover, we report a prevalence of GHD in children with NF1 of 2.5%, which has not been established earlier.<\/jats:p>","DOI":"10.1542\/peds.100.4.667","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T23:40:17Z","timestamp":1092440417000},"page":"667-670","source":"Crossref","is-referenced-by-count":66,"title":["Endocrinologic Disorders and Optic Pathway Gliomas in Children With Neurofibromatosis Type 1"],"prefix":"10.1542","volume":"100","author":[{"given":"Marjon H.","family":"Cnossen","sequence":"first","affiliation":[{"name":"From the Departments of Pediatrics,"},{"name":"Clinical Genetics,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther N.","family":"Stam","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatrics,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda C. M. G.","family":"Cooiman","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatrics,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huibert J.","family":"Simonsz","sequence":"additional","affiliation":[{"name":"Ophthalmology,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Stroink","sequence":"additional","affiliation":[{"name":"Neurology,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnold P.","family":"Oranje","sequence":"additional","affiliation":[{"name":"Dermatology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dicky J. 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