{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:27:04Z","timestamp":1791937624746,"version":"4.3.4"},"reference-count":52,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,11,1]]},"abstract":"<jats:p>Objectives.\u2003To investigate if the concentration of interleukin-6 (IL-6) in the cerebrospinal fluid (CSF) is affected by perinatal asphyxia, and to examine the relation of IL-6 levels in the CSF to the severity of hypoxic-ischemic encephalopathy (HIE), to brain damage, and to the neurological outcome.<\/jats:p><jats:p>Methods.\u2003Asphyxiated term neonates were included. Cerebrospinal fluid IL-6 was measured by a sensitive enzyme-linked immunosorbent assay.<\/jats:p><jats:p>Results.\u2003Twenty neonates were studied: 3 had no HIE, 5 had stage 1, 6 had stage 2, and 6 had stage 3. CSF IL-6 levels (8 to 90 hours of life) were higher in neonates with HIE stage 3 (range, 65 to 2250 pg\/mL) when compared with neonates with HIE stage 0 to 2 (&amp;lt;2 pg\/mL in 12 neonates, 10 pg\/mL in 1). According to neuroimaging techniques and\/or pathological examination, 14 neonates were normal, and 5 showed signs of brain damage; 1 was not classified. CSF IL-6 levels were significantly higher in neonates with signs of brain damage. Finally, 5 neonates had adverse outcomes (4 died, 1 had cerebral palsy), 2 had mild motor impairment, and 13 had normal outcomes. CSF IL-6 levels were higher in neonates with adverse outcomes (range, 65 to 2250 pg\/mL) compared with neonates with favorable outcomes.<\/jats:p><jats:p>Conclusion.\u2003The magnitude of IL-6 response in the CSF after perinatal asphyxia is related to the severity of neonatal HIE, to brain damage, and to the neurological outcome. Our results suggest that IL-6 might play a role in neonatal hypoxic-ischemic brain damage.<\/jats:p>","DOI":"10.1542\/peds.100.5.789","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T23:40:17Z","timestamp":1092440417000},"page":"789-794","source":"Crossref","is-referenced-by-count":99,"title":["Interleukin-6 in the Cerebrospinal Fluid After Perinatal Asphyxia Is Related to Early and Late Neurological Manifestations"],"prefix":"10.1542","volume":"100","author":[{"given":"Ana","family":"Mart\u0131\u0301n-Ancel","sequence":"first","affiliation":[{"name":"From the Department of Pediatrics, Division of Neonatology, and the"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Garc\u0131\u0301a-Alix","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Hospital Materno-Infantil, Las Palmas de Gran Canaria, 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