{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T16:53:50Z","timestamp":1769273630411,"version":"3.49.0"},"reference-count":27,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,1,1]]},"abstract":"<jats:p>Background.\u2003An imbalance between increased neutrophil elastase and a decreased antiprotease shield has been suggested as a factor contributing to the development of chronic lung disease (CLD). We hypothesized that administration of \u03b11-proteinase inhibitor (A1PI), also known as \u03b11-antitrypsin, to premature neonates would prevent CLD.<\/jats:p><jats:p>Design.\u2003A randomized, placebo-controlled, prospective study of A1PI supplementation was performed. Neonates &amp;lt;24 hours of age with birth weights 600\u20131000 g on respiratory support, and 1001\u20131250 g with respiratory distress syndrome (RDS) were eligible. Intravenous A1PI (60 mg\/kg) or placebo was infused on days 0, 4, 7, and 14. Primary outcome was CLD in survivors, defined as the need for supplemental oxygen on day 28.<\/jats:p><jats:p>Results.\u2003 A total of 106 patients were recruited. There were no significant differences between groups in birth weight or incidence of RDS. The incidence of CLD in survivors was lower in the treated group, but the difference did not reach statistical significance (relative risk [RR], 0.79; confidence interval [CI], 0.60\u20131.02). This beneficial trend persisted at 36 weeks corrected gestational age (RR, 0.48; CI, 0.23\u20131.00). The incidence of pulmonary hemorrhage was lower in the treated group (RR, 0.22; CI, 0.05\u20130.98). Other complications were not significantly different between groups.<\/jats:p><jats:p>Conclusions.\u2003In this, the first trial of a protease inhibitor for the prevention of CLD in premature infants, the infusions were well-tolerated. A1PI therapy may impede the development of CLD and appears to reduce the incidence of pulmonary hemorrhage in some neonates born prematurely.<\/jats:p>","DOI":"10.1542\/peds.101.1.89","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T23:44:32Z","timestamp":1092440672000},"page":"89-94","source":"Crossref","is-referenced-by-count":51,"title":["\u03b11-Proteinase Inhibitor Therapy for the Prevention of Chronic Lung Disease of Prematurity: A Randomized, Controlled Trial"],"prefix":"10.1542","volume":"101","author":[{"given":"Joseph A.","family":"Stiskal","sequence":"first","affiliation":[{"name":"University of Toronto, Toronto, Ontario, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Dunn","sequence":"additional","affiliation":[{"name":"From Women's College Hospital,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew T.","family":"Shennan","sequence":"additional","affiliation":[{"name":"From Women's College Hospital,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karel K. 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