{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T09:17:11Z","timestamp":1770974231159,"version":"3.50.1"},"reference-count":33,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,3,1]]},"abstract":"<jats:p>Objective.\u2003To describe the clinical characteristics of complicated parapneumonic effusions (CPE) in children caused by Streptococcus pneumoniae nonsusceptible to penicillin (PCN-N) and compare their clinical outcome with CPE caused by penicillin-susceptible (PCN-S) organisms.<\/jats:p><jats:p>Design.\u2003Children with parapneumonic effusions were identified retrospectively between July 1992 and June 1996. Charts of patients with CPE were reviewed for data obtained at the time of hospital admission. In addition, outpatient charts and\/or the families of children with CPE caused by PCN-N S pneumoniae were reviewed to identify specific risk factors associated with PCN-N organisms.<\/jats:p><jats:p>Results.\u2003Sixty-four cases of CPE were identified during the 4-year period. In 26 cases a bacterial pathogen was recovered, withS pneumoniae accounting for 23 of these isolates (88%). Of the 23 S pneumoniae cases, 17 were PCN-S and 6 cases were nonsusceptible. Complicated parapneumonic effusions caused by PCN-NS pneumoniae occurred in significantly younger patients than CPE that were PCN-S (2.1 years vs 7.9 years). Nonsusceptible effusions also had a higher incidence of bacteremia than PCN-S effusions (100% vs 29%). There were no significant differences between the two groups for duration of chest tube drainage, febrile days, oxygen use, and hospital stay.<\/jats:p><jats:p>Conclusion.\u2003CPE caused by PCN-N S pneumoniaeis associated with a younger age and higher rate of bacteremia than CPE caused by PCN-S strains. However, there were no significant differences in outcome measures between patients infected with susceptible or nonsusceptible organisms.<\/jats:p>","DOI":"10.1542\/peds.101.3.388","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T23:44:32Z","timestamp":1092440672000},"page":"388-392","source":"Crossref","is-referenced-by-count":38,"title":["Complicated Parapneumonic Effusions in Children Caused by Penicillin-Nonsusceptible<i>Streptococcus pneumoniae<\/i>"],"prefix":"10.1542","volume":"101","author":[{"given":"William D.","family":"Hardie","sequence":"first","affiliation":[{"name":"From the Divisions of Pulmonary Medicine and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy E.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Children's Hospital Medical Center, Cincinnati, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirley F.","family":"Reising","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Children's Hospital Medical Center, Cincinnati, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celia D. 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