{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:01:29Z","timestamp":1773288089942,"version":"3.50.1"},"reference-count":32,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,5,1]]},"abstract":"<jats:p>Objective.\u2003To determine whether very preterm infants who are oxygen-dependent at 28 days of life but not at 36 weeks' gestational age are at high risk of morbidities at 18 months.<\/jats:p><jats:p>Population.\u2003A total of 217 infants born in a tertiary care center at 24 to 28 weeks' gestation in 1987 to 1992, classified into three groups: neonatal comparison group, O2 &amp;lt;28 days of life (n = 76); bronchopulmonary dysplasia (BPD)-1, O2 \u226528 days but not at 36 weeks' gestational age (n = 48); and BPD-2, O2 \u226536 weeks (n = 93).<\/jats:p><jats:p>Outcome Measures.\u2003Growth, persistent respiratory problems (asthma, tracheostomy, home oxygen therapy), surgery, hospitalizations, and neurodevelopmental impairments.<\/jats:p><jats:p>Results.\u2003Among the three groups, no differences were found in weight, height, head circumference, or total number of days of rehospitalizations for any causes, or in rate of rehospitalizations to the intensive care unit, persistent respiratory problems, cerebral palsy, or sensory impairment. Children with BPD-2 needed more hernia repairs compared with the other two groups (comparison group: 12% vs BPD-1: 10% vs BPD-2: 30%), had more days of readmissions for respiratory problems (comparison group: 2.0 vs BPD-1: 2.0 vs BPD-2 6.3 [BPD-1 vs BPD-2]), had a lower mean developmental quotient (comparison group: 97.4 \u00b1 15.0 vs BPD-1: 97.9 \u00b1 11.6 vs BPD-2: 90.7 \u00b1 19.3). Intraparenchymal cerebral lesions, high family adversity, and prolonged ventilation were the most important factors influencing the developmental outcome.<\/jats:p><jats:p>Conclusion.\u2003Children with BPD-1 are similar in all respect at 18 months to children in the comparison group. Children with BPD-2 are similar to the other groups at 18 months in growth, general health, and neurologic outcome but differ in having a higher number of days of rehospitalizations for respiratory causes, more hernia repairs, and more developmental delays.<\/jats:p>","DOI":"10.1542\/peds.101.5.856","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T23:44:32Z","timestamp":1092440672000},"page":"856-860","source":"Crossref","is-referenced-by-count":104,"title":["Health and Developmental Outcomes at 18 Months in Very Preterm Infants With Bronchopulmonary Dysplasia"],"prefix":"10.1542","volume":"101","author":[{"given":"Marie-Claude","family":"Gre\u0301goire","sequence":"first","affiliation":[{"name":"From the Universite\u0301 de Montre\u0301al and the"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francine","family":"Lefebvre","sequence":"additional","affiliation":[{"name":"From the Universite\u0301 de Montre\u0301al and the"},{"name":"Department of Pediatrics, Ho\u0302pital Ste-Justine and Universite\u0301 de Montre\u0301al, Montre\u0301al, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Glorieux","sequence":"additional","affiliation":[{"name":"From the Universite\u0301 de Montre\u0301al and the"},{"name":"Department of Pediatrics, Ho\u0302pital Ste-Justine and Universite\u0301 de Montre\u0301al, Montre\u0301al, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[1998,5,1]]},"reference":[{"key":"2021121007120434400_B1","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1056\/NEJM196702162760701","article-title":"Pulmonary disease following respirator therapy of hyaline-membrane disease. 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