{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:27:44Z","timestamp":1787786864083,"version":"build-2784847793"},"reference-count":45,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,7,1]]},"abstract":"<jats:p>Background.\u2003Increased acute lower respiratory infection incidence, severity, and mortality are associated with malnutrition, and reduced immunological competence may be a mechanism for this association. Because zinc deficiency results in impaired immunocompetence and zinc supplementation improves immune status, we hypothesized that zinc deficiency is associated with increased incidence and severity of acute lower respiratory infection.<\/jats:p>\n               <jats:p>Methods.\u2003We evaluated the effect of daily supplementation with 10 mg of elemental zinc on the incidence and prevalence of acute lower respiratory infection in a double-blind, randomized, controlled trial in 609 children (zinc, n = 298; control, n = 311) 6 to 35 months of age. Supplementation and morbidity surveillance were done for 6 months.<\/jats:p>\n               <jats:p>Results.\u2003After 120 days of supplementation, the percentage of children with plasma zinc concentrations &amp;lt;60 \u03bcg\/dL decreased from 35.6% to 11.6% in the zinc group, whereas in the control group it increased from 36.8% to 43.6%. Zinc-supplemented children had 0.19 acute lower respiratory infection episodes\/child\/year compared with 0.35 episodes\/child\/year in the control children. After correction for correlation of data using generalized estimating equation regression methods, there was a reduction of 45% (95% confidence interval, 10% to 67%) in the incidence of acute lower respiratory infections in zinc-supplemented children.<\/jats:p>\n               <jats:p>Conclusions.\u2003A dietary zinc supplement resulted in a significant reduction in respiratory morbidity in preschool children. These findings suggest that interventions to improve zinc intake will improve the health and survival of children in developing countries.<\/jats:p>","DOI":"10.1542\/peds.102.1.1","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T23:44:32Z","timestamp":1092440672000},"page":"1-5","source":"Crossref","is-referenced-by-count":223,"title":["Zinc Supplementation Reduces the Incidence of Acute Lower Respiratory Infections in Infants and Preschool Children: A Double-blind,  Controlled Trial"],"prefix":"10.1542","volume":"102","author":[{"given":"Sunil","family":"Sazawal","sequence":"first","affiliation":[{"name":"From the Indian Council for Medical Research, Advanced Centre for Diarrhoeal Disease Research, Division of Paediatric Gastroenterology, All India Institute of Medical Sciences, New Delhi, India; and the"},{"name":"Department of International Health, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Black","sequence":"additional","affiliation":[{"name":"Department of International Health, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanju","family":"Jalla","sequence":"additional","affiliation":[{"name":"From the Indian Council for Medical Research, Advanced Centre for Diarrhoeal Disease Research, Division of Paediatric Gastroenterology, All India Institute of Medical Sciences, New Delhi, India; and the"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarmila","family":"Mazumdar","sequence":"additional","affiliation":[{"name":"From the Indian Council for Medical Research, Advanced Centre for Diarrhoeal Disease Research, Division of Paediatric Gastroenterology, All India Institute of Medical Sciences, New Delhi, India; and the"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anju","family":"Sinha","sequence":"additional","affiliation":[{"name":"From the Indian Council for Medical Research, Advanced Centre for Diarrhoeal Disease Research, Division of Paediatric Gastroenterology, All India Institute of Medical Sciences, New Delhi, India; and the"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maharaj K.","family":"Bhan","sequence":"additional","affiliation":[{"name":"From the Indian Council for Medical Research, Advanced Centre for Diarrhoeal Disease Research, Division of Paediatric Gastroenterology, All India Institute of Medical Sciences, New Delhi, India; and the"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[1998,7,1]]},"reference":[{"key":"2021121010150120300_B1","first-page":"138","article-title":"Mortality from acute respiratory infections in children under 5 years of age: global 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