{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T19:02:17Z","timestamp":1774119737197,"version":"3.50.1"},"reference-count":42,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,7,1]]},"abstract":"<jats:p>Objective.\u2003To examine the relationship between transient tachypnea of the newborn and asthma complicating pregnancy.<\/jats:p><jats:p>Design.\u2003Historical cohort analysis.<\/jats:p><jats:p>Setting.\u2003Singleton live deliveries in New Jersey hospitals during 1989 to 1992 (n = 447\u2009963).<\/jats:p><jats:p>Patients.\u2003Mother-infant dyads were identified from linked birth certificate and maternal and infant hospital claims data. Women with an International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) diagnosis code (493) for asthma (n = 2289) were compared with a four-fold larger randomly selected control sample (n = 9156) from the remaining pool of women.<\/jats:p><jats:p>Main Outcome Measure.\u2003Transient tachypnea of the newborn.<\/jats:p><jats:p>Results.\u2003In the overall sample, after controlling for the confounding effects of important variables, infants of asthmatic mothers were more likely [odds ratio (OR), 1.79; 95% confidence interval (CI), 1.35\u20132.37] than infants of control mothers to exhibit transient tachypnea of the newborn. A stratified analysis by gestational age and sex revealed larger and statistically significant associations in term infants (OR, 2.02; 95% CI, 1.42\u20132.87) as opposed to preterm infants (OR, 1.51; 95% CI, 0.94\u20132.43) and in male infants (OR, 1.91; 95% CI, 1.35\u20132.71) as opposed to female infants (OR, 1.51; 95% CI, 0.92\u20132.47). On the other hand, after adjusting for important confounding variables, respiratory distress syndrome and maternal asthma were not found to be associated (OR, 1.14; 95% CI, 0.79\u20131.64).<\/jats:p><jats:p>Conclusion.\u2003The results of this study provide evidence that maternal asthma is a risk factor for transient tachypnea of the newborn and differences in gestational age and sex were apparent in this association. The mechanism for this association remains to be determined.<\/jats:p>","DOI":"10.1542\/peds.102.1.84","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T23:44:32Z","timestamp":1092440672000},"page":"84-90","source":"Crossref","is-referenced-by-count":67,"title":["Maternal Asthma and Transient Tachypnea of the Newborn"],"prefix":"10.1542","volume":"102","author":[{"given":"Kitaw","family":"Demissie","sequence":"first","affiliation":[{"name":"From the Departments of Family Medicine,"},{"name":"Environmental and Community Medicine, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen W.","family":"Marcella","sequence":"additional","affiliation":[{"name":"Environmental and Community Medicine, and"},{"name":"Pediatrics, University of Medicine and Dentistry of New Jersey\u2014Robert Wood Johnson Medical School, New Brunswick, New Jersey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary B.","family":"Breckenridge","sequence":"additional","affiliation":[{"name":"From the Departments of Family Medicine,"},{"name":"Environmental and Community Medicine, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George G.","family":"Rhoads","sequence":"additional","affiliation":[{"name":"Environmental and Community Medicine, and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[1998,7,1]]},"reference":[{"key":"2021121010145939200_B1","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1001\/archpedi.1966.02090070078010","article-title":"Transient tachypnea of the newborn.","volume":"111","author":"Avery","year":"1966","journal-title":"Am J Dis Child"},{"key":"2021121010145939200_B2","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1001\/jama.1980.03300370050028","article-title":"Respiratory distress in the newborn.","volume":"243","author":"Miller","year":"1980","journal-title":"JAMA"},{"key":"2021121010145939200_B3","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1148\/98.1.69","article-title":"Radiologic findings in wet lung disease.","volume":"98","author":"Wesenberg","year":"1971","journal-title":"Radiology"},{"key":"2021121010145939200_B4","first-page":"153","article-title":"Transient tachypnea of the newborn. 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