{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:49:38Z","timestamp":1792496978808,"version":"4.5.0"},"reference-count":54,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,1,1]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To assess the predictive ability of a universal predischarge serum bilirubin measurement to screen for risk of subsequent significant hyperbilirubinemia in the direct Coombs negative healthy term and near-term newborn during the first postnatal week.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Total serum bilirubin (TSB) levels were obtained at the time of the routine metabolic screen in all term and near-term newborns cared for in the Pennsylvania Hospital Well Baby Nursery (n = 13\u2009003). Postnatal age (in hours) at the time of TSB measurement was recorded. A percentile-based bilirubin nomogram for the first week was constructed from hour-specific predischarge and postdischarge TSB values of newborns (n = 2840; median BW = 3230 g and median gestational age = 39 weeks) who met classification criteria for healthy newborns (excluding those with a positive direct Coombs test or those requiring phototherapy before age 60 hours) and who were enrolled in a hospital supervised home or outpatient follow-up program. The accuracy of the predischarge TSB as a predictor of subsequent degree of hyperbilirubinemia was determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>The study patients in the nomogram were racially diverse. Nearly 60% were breastfed. Predischarge, 6.1% of the study population (172\/2840) had TSB values in the high-risk zone (\u226595th percentile) at 18 to 72 hours; of these, 39.5% (68\/172) remained in that zone (likelihood ratio [LR] = 14.08, sensitivity = 54%; specificity = 96.2%, probability = 39.5%). Predischarge, 32.1% of the population (912\/2840) had TSB values in the intermediate-risk zone. In a clinically significant minority of these newborns (58\/912 or 6.4%), the postdischarge TSB moved into the high-risk zone (LR of this move: 3.2 from the upper-intermediate zone and .48 from the lower-intermediate risk zone). The predischarge TSB in 61.8% of the newborns (1756\/2840) was in the low-risk zone (&amp;lt;40th percentile) and there was no measurable risk for significant hyperbilirubinemia (LR = 0, sensitivity = 100%; specificity = 64.7%; probability = 0%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions.<\/jats:title><jats:p>An hour-specific TSB before hospital discharge can predict which newborn is at high, intermediate or low risk for developing clinically significant hyperbilirubinemia (specifically defined as TSB levels \u226595th percentile for age in hours). Risk designation and subsequent increases or decreases of in TSB can be easily monitored on an hour-specific percentile based predictive bilirubin nomogram. A predischarge TSB measured as a universal policy would facilitate targeted intervention and follow-up in a safe, cost-effective manner. In conjunction with bilirubin practice parameter of the American Academy of Pediatrics, it could reduce the potential risk for bilirubin-induced neurologic dysfunction.<\/jats:p><\/jats:sec>","DOI":"10.1542\/peds.103.1.6","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T23:45:45Z","timestamp":1092440745000},"page":"6-14","source":"Crossref","is-referenced-by-count":692,"title":["Predictive Ability of a Predischarge Hour-specific Serum Bilirubin for Subsequent Significant Hyperbilirubinemia in Healthy Term and Near-term Newborns"],"prefix":"10.1542","volume":"103","author":[{"given":"Vinod K.","family":"Bhutani","sequence":"first","affiliation":[{"name":"1 From the Section on Newborn Pediatrics, Pennsylvania Hospital, University of Pennsylvania Health System, Philadelphia, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lois","family":"Johnson","sequence":"additional","affiliation":[{"name":"1 From the Section on Newborn Pediatrics, Pennsylvania Hospital, University of Pennsylvania Health System, Philadelphia, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emidio M.","family":"Sivieri","sequence":"additional","affiliation":[{"name":"1 From the Section on Newborn Pediatrics, Pennsylvania Hospital, University of Pennsylvania Health System, Philadelphia, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[1999,1,1]]},"reference":[{"key":"2021121000312388300_B1"},{"key":"2021121000312388300_B2","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1542\/peds.93.6.1003","article-title":"Kernicterus in a full term infant.","volume":"93","author":"Penn","year":"1993","journal-title":"Pediatrics."},{"key":"2021121000312388300_B3","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1542\/peds.95.5.799","article-title":"Kernicterus in a full-term infant: the need for increased vigilance.","volume":"95","author":"Stevenson","year":"1995","journal-title":"Pediatrics."},{"key":"2021121000312388300_B4","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1542\/peds.96.4.730","article-title":"Kernicterus in otherwise healthy, breastfed term newborns.","volume":"96","author":"Maisels","year":"1995","journal-title":"Pediatrics."},{"key":"2021121000312388300_B5","first-page":"145","article-title":"Changes in clinical practice and bilirubin encephalopathy in healthy term newborns.","volume":"37","author":"Sola","year":"1995","journal-title":"Pediatr Res."},{"key":"2021121000312388300_B6","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1542\/peds.96.4.734","article-title":"Hidden risks: early discharge and bilirubin toxicity due to glucose-6-phosphate dehydrogenase deficiency.","volume":"96","author":"MacDonald","year":"1995","journal-title":"Pediatrics."},{"key":"2021121000312388300_B7","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1097\/00007611-199507000-00019","article-title":"Hemolytic jaundice due to G6PD deficiency causing kernicterus in newborn female.","volume":"88","author":"Washington","year":"1995","journal-title":"South Med J."},{"key":"2021121000312388300_B8","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0095-5108(18)30571-2","article-title":"Does hyperbilirubinemia damage the brain of healthy full-term infants?","volume":"17","author":"Newman","year":"1990","journal-title":"Clin Perinatol."},{"key":"2021121000312388300_B9","first-page":"483","article-title":"Hyperbilirubinemia in the term infant: when to worry, when to treat.","volume":"91","author":"Johnson","year":"1991","journal-title":"N Y State J Med."},{"key":"2021121000312388300_B10","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1542\/peds.89.5.809","article-title":"Evaluation and treatment of jaundice in the term newborn. 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