{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:00:38Z","timestamp":1791900038272,"version":"4.3.4"},"reference-count":32,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,4,1]]},"abstract":"<jats:p>Wolf-Hirschhorn syndrome (WHS) is a well-known chromosomal disorder attributable to partial deletion of the short arm of chromosome 4 (4p-). Although about 120 cases have been reported so far, there is still very little data on its natural history. Information given to parents at the time of diagnosis tends to be skewed to the extreme negative. To help delineate more thoroughly the natural history of WHS, and to obtain better information to answer parents' questions in a clinical setting, we evaluated 15 patients (12 females, 3 males) in three centers with the 4p- syndrome. Four of the cases had a follow-up spanning 16 years. Thirteen cases were detected by standard cytogenetics (regular G-banding 10, high-resolution banding 3), while the remaining 2 required fluorescence in situ hybridization. A total of 5\/15 (33.3%) had heart lesions; 7\/15 (46.6%) had oral facial clefts; 13\/15 (86.6%) had a seizure disorder, that tended to disappear with age; and 100% had severe\/profound developmental retardation. One Italian patient had sensorineural deafness and 1 Utah patient had a right split hand defect. Of note, 2 Utah patients were able to walk with support (at 4 and 12 years of age, respectively), whereas 3 Italian patients and 1 Utah patient were able to walk unassisted (at 4, 5, 5 years 9 months, and 7 years of age, respectively). Two of the 3 Italian patients also achieved sphincter control (by day). The 8 patients receiving serial electroencephalogram studies showed fairly distinctive abnormalities, usually outlasting seizures. A slow, but constant progress in development was observed in all cases, during the follow-up period. In conclusion, the combined cases of the three centers represent considerable experience, providing new information on several aspects of this important deletion syndrome.Wolf-Hirschhorn syndrome; del(4p) syndrome; natural history.<\/jats:p>","DOI":"10.1542\/peds.103.4.830","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T23:45:45Z","timestamp":1092440745000},"page":"830-836","source":"Crossref","is-referenced-by-count":116,"title":["Natural History of Wolf-Hirschhorn Syndrome: Experience With 15 Cases"],"prefix":"10.1542","volume":"103","author":[{"given":"Agatino","family":"Battaglia","sequence":"first","affiliation":[{"name":"Stella Maris Scientific Research Institute"},{"name":"Division of Medical Genetics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Carey","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peeches","family":"Cederholm","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Viskochil","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur R.","family":"Brothman","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Galasso","sequence":"additional","affiliation":[{"name":"Institute of Pediatrics"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[1999,4,1]]},"reference":[{"key":"2021121009362948800_B1","first-page":"14","article-title":"Apparent deletion of short arms of one chromosome (4 or 5) in a child with defects of midline fusion.","volume":"4","author":"Cooper","year":"1961","journal-title":"Mamm Chrom Nwsl."},{"key":"2021121009362948800_B2","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1399-0004.1980.tb00167.x","article-title":"The Wolf-Hirschhorn syndrome. 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