{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:27:21Z","timestamp":1765484841365,"version":"3.40.5"},"reference-count":12,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,4,1]]},"abstract":"<jats:p>Adverse drug reactions are a common clinical problem. It has been estimated1 that 6% to 15% of hospitalized patients experience some sort of adverse drug reaction. Clinical manifestations of adverse drug reactions include skin rash; a serum sickness-like reaction; drug fever; pulmonary, hepatic, and renal involvement; and systemic anaphylaxis. Many of these adverse events are not immunologically mediated. Actual allergic or immunologic drug reactions probably account for &amp;lt;25% of adverse drug reactions overall.1<\/jats:p>\n               <jats:p>Antibiotics are one of the major contributors to drug hypersensitivity. Cefaclor, an oral second-generation cephalosporin with a \u03b2-lactam ring, is used against various infectious diseases of the respiratory tract, especially in children. Several cases of cefaclor hypersensitivity have been reported.2,3 The most common presentations are either erythematous or papular eruptions, although serum sickness-like reactions have also been described. Anaphylactic reactions, although rare, have been observed in adults. Here we report a case of anaphylactic reaction to cefaclor in a 2\u00bd-year-old patient.<\/jats:p>","DOI":"10.1542\/peds.103.4.e50","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T23:45:45Z","timestamp":1092440745000},"page":"e50-e50","source":"Crossref","is-referenced-by-count":19,"title":["Anaphylactic Reaction to Oral Cefaclor in a Child"],"prefix":"10.1542","volume":"103","author":[{"given":"Masoud","family":"Grouhi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Hummel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaim M.","family":"Roifman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[1999,4,1]]},"reference":[{"key":"2021121009324931200_B1","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1001\/jama.1982.03330200061015","article-title":"Allergic reactions to drugs and biologic agents.","volume":"248","author":"Patterson","year":"1982","journal-title":"JAMA."},{"key":"2021121009324931200_B2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0091-6749(85)90048-X","article-title":"Anaphylaxis.","volume":"75","author":"Shelter","year":"1985","journal-title":"J Allergy Clin Immunol."},{"key":"2021121009324931200_B3","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1346-8138.1986.tb02932.x","article-title":"Anaphylaxis due to cefaclor hypersensitivity.","volume":"13","author":"Nishioka","year":"1986","journal-title":"J Dermatol."},{"key":"2021121009324931200_B4","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1177\/00034894810903S219","article-title":"Cefaclor in management of streptococcal pharyngitis, otitis media, and skin infections.","volume":"90","author":"Kammer","year":"1981","journal-title":"Ann Otol Rhinol Laryngol."},{"key":"2021121009324931200_B5","first-page":"560","article-title":"Cefaclor in the treatment of otitis media and pharyngitis in children.","volume":"134","author":"McLinn","year":"1980","journal-title":"Am J Dis Child."},{"key":"2021121009324931200_B6"},{"key":"2021121009324931200_B7","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1056\/NEJM198010233031716","article-title":"Cefaclor: a cluster of adverse reactions.","volume":"303","author":"Murray","year":"1980","journal-title":"N Engl J Med."},{"key":"2021121009324931200_B8","first-page":"2","article-title":"Hypersensitivity reactions to cefaclor.","volume":"47","author":"Swedish Adverse Drug Reaction Advisory Committee","year":"1986","journal-title":"Bull SADRAC."},{"key":"2021121009324931200_B9","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/S0140-6736(88)92137-X","article-title":"High incidence of anaphylactic reaction to cefaclor.","volume":"1","author":"Hama","year":"1988","journal-title":"Lancet."},{"key":"2021121009324931200_B10","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/00006454-198609000-00013","article-title":"Cross-sensitivity to cephalosporins in patients allergic to penicillin.","volume":"5","author":"Anderson","year":"1986","journal-title":"Pediatr Infect Dis J."},{"key":"2021121009324931200_B11","doi-asserted-by":"crossref","first-page":"S364","DOI":"10.1093\/infdis\/128.Supplement_2.S364","article-title":"Antigenicity and cross-reactivity of penicillin and cephalosporins.","volume":"128","author":"Levine","year":"1973","journal-title":"J Infect Dis."},{"key":"2021121009324931200_B12","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1001\/archinte.1992.00400170020005","article-title":"A perspective on penicillin allergy.","volume":"152","author":"Lin","year":"1992","journal-title":"Arch Intern Med."}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/103\/4\/e50\/842289\/e50.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/103\/4\/e50\/842289\/e50.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T21:20:46Z","timestamp":1639171246000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/103\/4\/e50\/65921\/Anaphylactic-Reaction-to-Oral-Cefaclor-in-a-Child"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,4,1]]},"references-count":12,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1999,4,1]]},"published-print":{"date-parts":[[1999,4,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.103.4.e50","relation":{},"ISSN":["1098-4275","0031-4005"],"issn-type":[{"type":"electronic","value":"1098-4275"},{"type":"print","value":"0031-4005"}],"subject":[],"published":{"date-parts":[[1999,4,1]]}}}