{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:29:24Z","timestamp":1758126564005,"version":"3.40.5"},"reference-count":27,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,5,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives.<\/jats:title>\n                  <jats:p>To explore: 1) the relationship between plasma insulin-like growth factor-1 (IGF-1) and other markers of growth; and 2) the effect of serum concentrations of tumor necrosis factor \u03b1 (TNF) on growth variables in children (2\u201310 years) stunted by Trichuris dysentery syndrome (TDS), recovering cases, and their matched controls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Method.<\/jats:title>\n                  <jats:p>Fourteen patients with TDS were admitted to the Tropical Metabolism Research Unit, treated with albendazole and iron, and then followed with matched controls (n = 28) for 1 year. Anthropometric and biochemical measurements were done on admission and then every 3 months for the year. Plasma IGF-1, the carboxyterminal propeptide of type 1 procollagen, serum TNF, total serum protein, serum albumin, and complete blood count were determined.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results.<\/jats:title>\n                  <jats:p>Low admission plasma levels of IGF-1 in TDS cases were accompanied by high serum levels of TNF, and total serum protein, normal serum albumin, low hemoglobin, reduced collagen synthesis (low plasma carboxyterminal propeptide of type 1 procollagen), and growth failure. These variables improved significantly after treatment. Plasma levels of IGF-1 were significantly related to theZ-scores for height-for-age (r = 0.60, 0.73, 0.68) and weight-for-age (r = 0.69, 0.80, 0.69) of cases and controls, height-for-age (r = 0.51, 0.52, 0.54) and weight-for-age (r = 0.51, 0.52, 0.54) at each measurement throughout the year. Serum levels of TNF were not related to any of the growth variables.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion.<\/jats:title>\n                  <jats:p>These findings may contribute to the understanding of growth failure in children affected by other forms of chronic inflammatory bowel disease.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.103.5.e69","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T23:45:45Z","timestamp":1092440745000},"page":"e69-e69","source":"Crossref","is-referenced-by-count":11,"title":["Plasma Insulin-like Growth Factor-1, Type 1 Procollagen, and Serum Tumor Necrosis Factor \u03b1 in Children Recovering From<i>Trichuris<\/i> Dysentery Syndrome"],"prefix":"10.1542","volume":"103","author":[{"given":"E. Marilyn Watson","family":"Duff","sequence":"first","affiliation":[{"name":"1 From the Tropical Metabolism Research Unit, University of the West Indies."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nutr), MSc (Nutr),","family":"BScN","sequence":"additional","affiliation":[{"name":"1 From the Tropical Metabolism Research Unit, University of the West Indies."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norma McFarlane","family":"Anderson","sequence":"additional","affiliation":[{"name":"1 From the Tropical Metabolism Research Unit, University of the West Indies."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward S.","family":"Cooper","sequence":"additional","affiliation":[{"name":"1 From the Tropical Metabolism Research Unit, University of the West Indies."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[1999,5,1]]},"reference":[{"key":"2021121010153165200_B1","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/0035-9203(93)90074-Z","article-title":"Developmental levels and nutritional status of children with the Trichuris dysentery syndrome.","volume":"87","author":"Callender","year":"1993","journal-title":"Trans R Soc Trop Med Hyg."},{"key":"2021121010153165200_B2","first-page":"13","article-title":"Does poor health and nutrition affect school achievement in rural Jamaican children?","volume":"45","author":"Hutchinson","year":"1996","journal-title":"West Indian Med J."},{"key":"2021121010153165200_B3","doi-asserted-by":"crossref","first-page":"S91","DOI":"10.1017\/S0031182000075272","article-title":"Intestinal nematode infections in children: the pathophysiological price paid.","volume":"104","author":"Cooper","year":"1992","journal-title":"Parasitology."},{"key":"2021121010153165200_B4","first-page":"285","article-title":"Growth suppression in the Trichuris dysentery syndrome.","volume":"44","author":"Cooper","year":"1990","journal-title":"Eur J Clin Nutr."},{"key":"2021121010153165200_B5","first-page":"1522","article-title":"Normative data for insulin-like growth factors (IGFs), IGF binding proteins and growth hormone binding protein in a healthy Spanish population: age and sex-related changes.","volume":"77","author":"Argente","year":"1993","journal-title":"J Clin Endocrinol Metab."},{"key":"2021121010153165200_B6","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1172\/JCI115327","article-title":"Secretion of insulin-like growth factor-1 binding proteins by murine bone marrow stromal cells.","volume":"88","author":"Abboud","year":"1991","journal-title":"J Clin Invest."},{"key":"2021121010153165200_B7","first-page":"1009","article-title":"Growth factors and their potential clinical value.","volume":"75","author":"Canalis","year":"1992","journal-title":"J Clin Endocrinol Metab."},{"key":"2021121010153165200_B8"},{"key":"2021121010153165200_B9","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1056\/NEJM197907123010204","article-title":"The biosynthesis of collagen and its disorders.","volume":"301","author":"Prockup","year":"1979","journal-title":"N Engl J Med."},{"key":"2021121010153165200_B10","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0016-5085(91)90271-L","article-title":"Comparison of collagen propeptides as growth markers in children with inflammatory bowel disease.","volume":"100","author":"Hyams","year":"1991","journal-title":"Gastroenterology."},{"key":"2021121010153165200_B11","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1203\/00006450-199109000-00016","article-title":"Serum concentrations of the type I and type II procollagen propeptides as biochemical markers of growth velocity in healthy infants and children and in children with growth disorders.","volume":"30","author":"Trivedi","year":"1991","journal-title":"Pediatr Res."},{"key":"2021121010153165200_B12","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3181\/00379727-200-43426","article-title":"Tumor necrosis factor and regulation of metabolism in infection: role of systemic versus tissue levels.","volume":"200","author":"Tracey","year":"1992","journal-title":"Proc Soc Exp Biol Med."},{"key":"2021121010153165200_B13","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0035-9203(94)90072-8","article-title":"Immunoepidemiology of intestinal helminth infections. 3. Mucosal macrophages and cytokine production in the colon of children with Trichuris trichiura dysentery.","volume":"88","author":"MacDonald","year":"1994","journal-title":"Trans R Soc Trop Med Hyg."},{"key":"2021121010153165200_B14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/jcp.50.3.236","article-title":"Plasma proteins in children with Trichuris dysentery syndrome.","volume":"50","author":"Cooper","year":"1997","journal-title":"J Clin Pathol."},{"key":"2021121010153165200_B15","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/0035-9203(83)90103-7","article-title":"The adverse consequences of heavy Trichuris infection.","volume":"77","author":"Gilman","year":"1983","journal-title":"Trans R Soc Trop Med Hyg."},{"key":"2021121010153165200_B16"},{"key":"2021121010153165200_B17","first-page":"1404","article-title":"Intestinal permeability, diet and growth.","volume":"338","author":"Finzi-Smith","year":"1991","journal-title":"Lancet."},{"key":"2021121010153165200_B18"},{"key":"2021121010153165200_B19","first-page":"1009","article-title":"Skeletal growth factors and aging.","volume":"78","author":"Canalis","year":"1994","journal-title":"J Endocrinol Metab."},{"key":"2021121010153165200_B20","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S0022-3476(94)70203-9","article-title":"Increases in hemoglobin concentration and iron needs in response to growth hormone treatment.","volume":"125","author":"Vihervuori","year":"1994","journal-title":"J Pediatr."},{"key":"2021121010153165200_B21","first-page":"190","article-title":"Changes in insulin-like growth factor-1 (IGF-1), IGF binding protein-3, growth hormone (GH)-binding protein, erythrocyte IGF-1 receptors, and growth rate during GH treatment.","volume":"80","author":"Mandel","year":"1995","journal-title":"J Clin Endocrinol Metab."},{"key":"2021121010153165200_B22","first-page":"217","article-title":"Cytokines: their relevance to nutrition.","volume":"43","author":"Grimble","year":"1989","journal-title":"Eur J Clin Nutr."},{"key":"2021121010153165200_B23","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/ajcn\/61.1.116","article-title":"IGF-1 alters energy expenditure and protein metabolism during parenteral feeding in rats.","volume":"61","author":"Ling","year":"1995","journal-title":"Am J Nutr."},{"key":"2021121010153165200_B24","first-page":"80","article-title":"Nutritional regulation of the insulin-like growth factors.","volume":"15","author":"Thissen","year":"1994","journal-title":"Endocr Rev."},{"key":"2021121010153165200_B25","first-page":"705","article-title":"Plasma somatomedin-C in Nigerian malnourished children fed a vegetable protein rehabilitation diet.","volume":"43","author":"Smith","year":"1989","journal-title":"Eur J Clin Nutr."},{"key":"2021121010153165200_B26","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1042\/cs0840169","article-title":"Acute-phase protein response is impaired in severely malnourished children.","volume":"84","author":"Doherty","year":"1993","journal-title":"Clin Sci."},{"key":"2021121010153165200_B27","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1093\/jn\/122.11.2066","article-title":"Cysteine and glycine supplementation modulate the metabolic response to tumor necrosis factor alpha in rats fed a low protein diet.","volume":"122","author":"Grimble","year":"1992","journal-title":"J Nutr."}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/103\/5\/e69\/841485\/e69.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/103\/5\/e69\/841485\/e69.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T22:41:38Z","timestamp":1639176098000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/103\/5\/e69\/65401\/Plasma-Insulin-like-Growth-Factor-1-Type-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,5,1]]},"references-count":27,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1999,5,1]]},"published-print":{"date-parts":[[1999,5,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.103.5.e69","relation":{},"ISSN":["1098-4275","0031-4005"],"issn-type":[{"type":"electronic","value":"1098-4275"},{"type":"print","value":"0031-4005"}],"subject":[],"published":{"date-parts":[[1999,5,1]]}}}