{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T08:15:34Z","timestamp":1788682534046,"version":"build-2803163510"},"reference-count":27,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,8,1]]},"abstract":"<jats:p>Kikuchi's disease (KD), or histiocytic necrotizing lymphadenitis, was initially described in Japan in 1972. In the following years, several series of cases involving patients of different ages, races, and geographic origins were reported, but pediatric reports have been rare.<\/jats:p>\n               <jats:p>The etiology of KD is unknown, although a viral or autoimmune hypothesis has been suggested. The most frequent clinical manifestation consists of local or generalized adenopathy, although in some cases, it is associated with more general symptoms, multiorganic involvement, and diverse analytic changes (leukopenia, elevated erythrocyte sedimentation rate, and C-reactive protein, as well as an increase of transaminases and serum lactic dehydrogenase).<\/jats:p>\n               <jats:p>Diagnosis is based on characteristic pathologic findings that permit differentiation of this disease from lymphoma, systemic lupus erythematosus, and infectious lymphadenopathies.<\/jats:p>\n               <jats:p>We present here the case of a 14-year-old boy who presented with severe systemic manifestations and transient fulminant hepatic failure in response to treatment with antituberculosis drugs. Kikuchi's disease, lymphadenitis, liver failure, antituberculosis drugs.<\/jats:p>","DOI":"10.1542\/peds.104.2.e24","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T23:45:45Z","timestamp":1092440745000},"page":"e24-e24","source":"Crossref","is-referenced-by-count":36,"title":["Kikuchi's Disease With Multisystemic Involvement and Adverse Reaction to Drugs"],"prefix":"10.1542","volume":"104","author":[{"given":"Maria L. Murga","family":"Sierra","sequence":"first","affiliation":[{"name":"From the Department of Pediatrics,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Vegas","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier E.","family":"Blanco-Gonza\u0301lez","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almudena","family":"Gonza\u0301lez","sequence":"additional","affiliation":[{"name":"Pathology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Mart\u0131\u0301nez","sequence":"additional","affiliation":[{"name":"Pathology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Calero","sequence":"additional","affiliation":[{"name":"Hematology, Hospital Universitario Pr\u0131\u0301ncipe de Asturias, Alcala\u0301 de Henares, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[1999,8,1]]},"reference":[{"key":"2021121002585174900_B1","first-page":"379","article-title":"Lymphadenitis showing focal reticulum cell hyperplasia with nuclear debris and phagocytosis.","volume":"35","author":"Kikuchi","year":"1972","journal-title":"Nippon Ketsueki Gakkai Zasshi."},{"key":"2021121002585174900_B2","first-page":"920","article-title":"Cervical subacute necrotizing lymphadenitis. A new clinicopathologic agent.","volume":"20","author":"Fujimoto","year":"1972","journal-title":"Naika."},{"key":"2021121002585174900_B3","first-page":"329","article-title":"Kikuchi's histiocytic necrotizing lymphadenitis: an analysis of 108 cases with emphasis on differential diagnosis.","volume":"5","author":"Dorfman","year":"1988","journal-title":"Semin Diagn Pathol"},{"key":"2021121002585174900_B4","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/00000478-199403000-00001","article-title":"Kikuchi's Lymphadenitis. A morphologic analysis of 75 cases with special reference to unusual features.","volume":"18","author":"Tsang","year":"1994","journal-title":"Am J Surg Pathol"},{"key":"2021121002585174900_B5","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1097\/00000478-199507000-00008","article-title":"Kukuchi's disease (histiocytic necrotizing lymphadenitis). A clinicopathologic study of 79 cases with an analysis of histologic subtypes, immunohistology and DNA ploidy.","volume":"19","author":"Kuo","year":"1995","journal-title":"Am J Surg Pathol"},{"key":"2021121002585174900_B6","first-page":"35","article-title":"Mesenterial histiocytic necrotizing lymphadenitis.","volume":"42","author":"Rudin","year":"1987","journal-title":"Helv Pediat Acta."},{"key":"2021121002585174900_B7","first-page":"152","article-title":"Necrotizing lymphadenitis (Kikuchi's disease).","volume":"91","author":"Smith","year":"1993","journal-title":"Pediatrics"},{"key":"2021121002585174900_B8","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1001\/archpedi.1994.02170040093018","article-title":"Pathological cases of the month. Kikuchi's disease (histiocytic necrotizing lymphadenitis).","volume":"148","author":"Boyce","year":"1994","journal-title":"Arch Pediatr Adolesc Med."},{"key":"2021121002585174900_B9","first-page":"213","article-title":"Enfermedad de Kikuchi o linfadenitis necrotizante histiocitaria.","volume":"42","author":"Calvo","year":"1995","journal-title":"An Esp Pediatr."},{"key":"2021121002585174900_B10","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1542\/peds.98.1.130","article-title":"Histiocytic necrotizing lymphadenitis with autoimmune phenomena and meningitis in a 14-year-old girl.","volume":"98","author":"Debley","year":"1996","journal-title":"Pediatrics"},{"key":"2021121002585174900_B11","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1055\/s-2008-1066464","article-title":"Axillary involvement in pediatric Kikuchi's disease.","volume":"6","author":"Heldenberg","year":"1996","journal-title":"Eur J Pediatr Surg."},{"key":"2021121002585174900_B12","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0002-9343(96)00231-8","article-title":"Kikuchi\u2013Fujimoto disease: a benign cause of fever and lymphadenopathy.","volume":"171","author":"Norris","year":"1996","journal-title":"Am J Med"},{"key":"2021121002585174900_B13","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/BF00429352","article-title":"Histiocytic necrotizing lymphadenitis without granulocytic infiltration.","volume":"395","author":"Pileri","year":"1982","journal-title":"Virchows Arch [A]."},{"key":"2021121002585174900_B14","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/BF01092760","article-title":"Skin involvement in Kikuchi's disease: an immunocytochemical and immunofluorescence study.","volume":"430","author":"Aqel","year":"1997","journal-title":"Virchows Arch."},{"key":"2021121002585174900_B15","first-page":"937","article-title":"Involvement of the intraabdominal lymph nodes in a case of subacute necrotizing lymphadenitis.","volume":"34","author":"Tsujino","year":"1993","journal-title":"Rinsho-Ketsueki."},{"key":"2021121002585174900_B16","doi-asserted-by":"crossref","first-page":"821","DOI":"10.2169\/internalmedicine.35.821","article-title":"Recurrent histiocytic necrotizing lymphadenitis (Kikuchi's disease) in an human T lymphotropic virus type I carrier.","volume":"35","author":"Atarashi","year":"1996","journal-title":"Intern Med."},{"key":"2021121002585174900_B17"},{"key":"2021121002585174900_B18","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1093\/ajcp\/102.4.454","article-title":"Fine-needle aspiration cytologic diagnosis of Kikuchi's lymphadenitis. A report of 27 cases.","volume":"102","author":"Tsang","year":"1994","journal-title":"Am J Clin Pathol"},{"key":"2021121002585174900_B19","first-page":"383","article-title":"Kikuchi's disease: a case report with emphasis on flow cytometric studies.","volume":"41","author":"Lima","year":"1996","journal-title":"Sangre"},{"key":"2021121002585174900_B20","first-page":"134","article-title":"An investigation of the viral pathogenesis of Kikuchi\u2013Fujimoto disease. Lack of evidence for Epstein-Barr virus or human herpesvirus type 6 as the causative agents.","volume":"118","author":"Hollingsworth","year":"1994","journal-title":"Arch Pathol Lab Med."},{"key":"2021121002585174900_B21","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0049-0172(96)80028-X","article-title":"Necrotizing lymphadenitis associated with systemic lupus erythematosus.","volume":"26","author":"Eisner","year":"1996","journal-title":"Semin Arthritis Rheum."},{"key":"2021121002585174900_B22","first-page":"568","article-title":"Two more cases of Still's disease and Kikuchi's.","volume":"17","author":"Lyberatos","year":"1990","journal-title":"J Rheumatol."},{"key":"2021121002585174900_B23","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/S0140-6736(89)90997-5","article-title":"Kikuchi's disease with liver dysfunction presenting as fever of unknown origin.","volume":"21","author":"Bailey","year":"1989","journal-title":"Lancet"},{"key":"2021121002585174900_B24","first-page":"191","article-title":"A rare case of hypersensitivity to multiple antituberculosis drugs.","volume":"1","author":"Olle Goig","year":"1997","journal-title":"Int J Tuberc Lung Dis"},{"key":"2021121002585174900_B25","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1164\/ajrccm.157.6.9711039","article-title":"Antituberculosis drug-induced hepatotoxicity. The role of hepatitis C virus and the human immunodeficiency virus.","volume":"157","author":"Ungo","year":"1998","journal-title":"Am J Respir Crit Care Med."},{"key":"2021121002585174900_B26","first-page":"332","article-title":"Kikuchi\u2013Fujimoto disease: benign cause of fever and lymphadenopathy.","volume":"103","author":"Yoo","year":"1997","journal-title":"Am J Med"},{"key":"2021121002585174900_B27","first-page":"1995","article-title":"Kikuchi's disease associated with lupus-like syndrome\u2014a fatal case.","volume":"19","author":"Shih-Hua","year":"1992","journal-title":"J Rheumatol"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/104\/2\/e24\/842675\/e24.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/104\/2\/e24\/842675\/e24.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T09:28:04Z","timestamp":1639128484000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/104\/2\/e24\/62458\/Kikuchi-s-Disease-With-Multisystemic-Involvement"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,8,1]]},"references-count":27,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1999,8,1]]},"published-print":{"date-parts":[[1999,8,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.104.2.e24","relation":{},"ISSN":["1098-4275","0031-4005"],"issn-type":[{"value":"1098-4275","type":"electronic"},{"value":"0031-4005","type":"print"}],"subject":[],"published":{"date-parts":[[1999,8,1]]}}}