{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:16:25Z","timestamp":1790900185042,"version":"4.1.0"},"reference-count":25,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,9,1]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To report the current incidence and the need for surgery for retinopathy of prematurity (ROP) in neonates (22\u201336 weeks' gestational age [GA], July 1, 1989 through June 30, 1997).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design.<\/jats:title><jats:p>Retrospective analyses using computerized perinatal database kept on all admissions, a review of patient charts, and eye examination log books.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting.<\/jats:title><jats:p>Level 3 regional referral NICU.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients.<\/jats:title><jats:p>A total of 2528 infants &amp;lt;37 weeks' GA were admitted during this time. Of these infants, 950 met the criteria for eye examination beginning at 4 to 6 weeks of age and repeated every 2 weeks until complete vascularization of the retina or death or discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>The incidence of ROP was (202\/950) 21.3% for any stage and 4.6% (44\/950) for stage 3 ROP or greater. No ROP was noted in infants born at &amp;gt;32 weeks' GA. No infant born at &amp;gt;28 weeks needed retinal surgery. Using birth weight (BW) criteria, stage 3 ROP was not noted in infants with BWs &amp;gt;1500 g; retinal surgery was not needed in infants with BWs &amp;gt;1000 g. A number of perinatal factors were associated with ROP on univariate analysis. However, using multiple logistic regression analyses of these factors, only GA and days on supplemental oxygen therapy were associated significantly with the development of ROP. Despite increased survival of extremely low BW infants, we found a considerable reduction in incidence and severity of ROP compared with reports from an earlier chronological period. However, infants &amp;lt;28 weeks' GA or with BWs &amp;lt;1000 g were still at considerable risk for retinal surgical treatment for ROP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>We conclude that the incidence and severity of ROP have decreased significantly in the present era of surfactant therapy.<\/jats:p><\/jats:sec>","DOI":"10.1542\/peds.104.3.e26","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T23:45:45Z","timestamp":1092440745000},"page":"e26-e26","source":"Crossref","is-referenced-by-count":99,"title":["Current Incidence of Retinopathy of Prematurity, 1989\u20131997"],"prefix":"10.1542","volume":"104","author":[{"given":"Naveed","family":"Hussain","sequence":"first","affiliation":[{"name":"From the Department of Pediatrics; and the"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Clive","sequence":"additional","affiliation":[{"name":"Office of Biostatistical Consultation, University of Connecticut, School of Medicine, John Dempsey Hospital, Farmington, Connecticut."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vineet","family":"Bhandari","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics; and the"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[1999,9,1]]},"reference":[{"key":"2021121003011744700_B1","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1136\/bjo.69.7.500","article-title":"Retinopathy of prematurity: review of a four year period.","volume":"69","author":"Cats","year":"1985","journal-title":"Br J Ophthalmol"},{"key":"2021121003011744700_B2","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1651-2227.1994.tb13067.x","article-title":"Retinopathy of prematurity: review of a seven-year period in a Danish neonatal intensive care unit.","volume":"83","author":"Arroe","year":"1994","journal-title":"Acta Pediatr"},{"key":"2021121003011744700_B3","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/S0161-6420(91)32074-8","article-title":"Incidence and course of retinopathy of prematurity.","volume":"98","author":"Palmer","year":"1991","journal-title":"Ophthalmology"},{"key":"2021121003011744700_B4","first-page":"37","article-title":"Why is there an increase in ROP in recent years?","volume":"241","author":"Tan","year":"1991","journal-title":"Bull Soc Belg Ophthalmol"},{"key":"2021121003011744700_B5","first-page":"42","article-title":"Retinopathy of prematurity in extremely low birth weight infants.","volume":"95","author":"Keith","year":"1995","journal-title":"Pediatrics"},{"key":"2021121003011744700_B6"},{"key":"2021121003011744700_B7","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1542\/peds.102.6.1333","article-title":"Annual summary of vital statistics, 1997.","volume":"102","author":"Guyer","year":"1998","journal-title":"Pediatrics"},{"key":"2021121003011744700_B8","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1001\/archopht.1984.01040030908011","article-title":"An international classification for retinopathy of prematurity.","volume":"102","author":"The Committee for the Classification of Retinopathy of Prematurity","year":"1984","journal-title":"Arch Ophthalmol"},{"key":"2021121003011744700_B9","first-page":"542","article-title":"Gestational age assessment in preterm neonates weighing less than 1500 grams.","volume":"88","author":"Sanders","year":"1991","journal-title":"Pediatrics"},{"key":"2021121003011744700_B10","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1136\/adc.46.250.783","article-title":"A growth chart for premature and other infants.","volume":"46","author":"Gairdner","year":"1971","journal-title":"Arch Dis Child"},{"key":"2021121003011744700_B11","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0031-3955(16)34975-6","article-title":"Necrotizing enterocolitis: treatment based on staging criteria.","volume":"33","author":"Walsh","year":"1986","journal-title":"Pediatr Clin North Am"},{"key":"2021121003011744700_B12"},{"key":"2021121003011744700_B13","first-page":"131","article-title":"Pre-discharge outcomes of 22\u201327 weeks gestational age infants born at tertiary care centers in Connecticut: implications for perinatal management.","volume":"62","author":"Hussain","year":"1998","journal-title":"Conn Med"},{"key":"2021121003011744700_B14","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0002-9394(42)92088-9","article-title":"Extreme prematurity and fibroblastic overgrowth of persistant vascular sheath behind each crystalline lens. 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