{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T05:20:39Z","timestamp":1789363239085,"version":"build-2803163510"},"reference-count":30,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective.<\/jats:title>\n                    <jats:p>Because previous studies have found allergic contact sensitization common in children by 5 years of age, our aim was to determine the prevalence of positive epicutaneous test results in children &amp;lt;5 years of age and to determine whether sensitization to contact allergens was as common in infancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>We recruited 95 asymptomatic children 6 months to 5 years of age from well-child visits at Denver area pediatric practices for epicutaneous patch testing using the T.R.U.E. Test system. Allergens were placed on the skin for 48 hours, and at a later follow-up visit, positive reactions were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>A total of 85 patients completed the study. Of these, 20 (24.5%) had 1 or more positive reactions to the tested allergens. Positive reactors ranged from 6 to 65.5 months of age, with an average of 30.4 months of age. Of the children, 16 reacted to 1 allergen, and 4 reacted to 2. Eleven positive reactions were observed to nickel, followed by 8 to thimerosal. Other positive reactions were to neomycin, cobalt, and kathon CG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions.<\/jats:title>\n                    <jats:p>Children as young as 6 months of age may be sensitized to contact allergens. Within this pediatric population, the prevalence of sensitization is 24.5%. Sensitization to contact allergens may occur in infants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1542\/peds.105.1.e3","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T19:50:41Z","timestamp":1092426641000},"page":"e3-e3","source":"Crossref","is-referenced-by-count":107,"title":["Does Sensitization to Contact Allergens Begin in Infancy?"],"prefix":"10.1542","volume":"105","author":[{"given":"Anna L.","family":"Bruckner","sequence":"first","affiliation":[{"name":"From the Departments of Pediatrics and Dermatology, University of Colorado Health Sciences Center, Denver, Colorado."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William L.","family":"Weston","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatrics and Dermatology, University of Colorado Health Sciences Center, Denver, Colorado."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph 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