{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:31:36Z","timestamp":1790260296998,"version":"4.1.0"},"reference-count":63,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,2,1]]},"abstract":"<jats:p>We describe a term infant with congenital cutaneous candidiasis (CCC), and review all cases in the English literature that reported birth weight and outcome. Presence of an intrauterine foreign body was a predisposing factor for development of CCC and subsequent preterm birth. The most common presentation of CCC in neonates weighing &amp;gt;1000 g was a generalized eruption of erythematous macules, papules, and\/or pustules that sometimes evolved to include vesicles and bullae. Extremely low birth weight, premature neonates weighing &amp;lt;1000 g most often presented with a widespread desquamating and\/or erosive dermatitis (10 of 15 [67%]), and were at greater risk for systemic infection with Candidaspp (10 of 15 [67%]) and death (6 of 15 [40%] than those weighing &amp;gt;1000 g (5 of 48 [10%]; 4 of 48 [8%], respectively). Systemic antifungal therapy is recommended for neonates with burn-like dermatitis attributable to Candida spp, or positive blood, urine, and\/or cerebrospinal fluid cultures. Systemic treatment also should be considered for all infants with CCC who have respiratory distress in the immediate neonatal period and\/or laboratory signs of sepsis such as an elevated leukocyte count with an increase in immature forms or persistent hyperglycemia and glycosuria.<\/jats:p>","DOI":"10.1542\/peds.105.2.438","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T19:50:41Z","timestamp":1092426641000},"page":"438-444","source":"Crossref","is-referenced-by-count":174,"title":["Congenital Cutaneous Candidiasis: Clinical Presentation, Pathogenesis, and Management Guidelines"],"prefix":"10.1542","volume":"105","author":[{"given":"Gary L.","family":"Darmstadt","sequence":"first","affiliation":[{"name":"Division of Infectious Disease and"},{"name":"Division of Dermatology"},{"name":"Division of Dermatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James 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