{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:56:56Z","timestamp":1790909816720,"version":"4.1.0"},"reference-count":15,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,3,1]]},"abstract":"<jats:p>Lymphocytic choriomeningitis virus (LCMV), a human zoonosis caused by a rodent-borne arenavirus, has been associated with both postnatal and intrauterine human disease. Infection in man is acquired after inhalation, ingestion, or direct contact with virus found in the urine, feces, and saliva of infected mice, hamsters, and guinea pigs. Congenital LCMV infection is a significant, often unrecognized cause of chorioretinitis, hydrocephalus, microcephaly or macrocephaly, and mental retardation. Acquired LCMV infection, asymptomatic in approximately one third of individuals, is productive of central nervous system manifestations in one half of the remaining cases. Aseptic meningitis or meningoencephalitis are the predominant syndromes, although transverse myelitis, a Guillain-Barre\u0301-type syndrome, as well as transient and permanent acquired hydrocephalus have also been reported. Fatalities are rare. We report a patient with meningoencephalitis attributable to LCMV and discuss the spectrum of central nervous system disease, newer diagnostic modalities, and preventive strategies. lymphocytic choriomeningitis virus, aseptic meningitis, meningoencephalitis, zoonosis, hydrocephalus, arenavirus.<\/jats:p>","DOI":"10.1542\/peds.105.3.e35","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T23:50:41Z","timestamp":1092441041000},"page":"e35-e35","source":"Crossref","is-referenced-by-count":95,"title":["Lymphocytic Choriomeningitis Virus: Reemerging Central Nervous System Pathogen"],"prefix":"10.1542","volume":"105","author":[{"given":"Leslie L.","family":"Barton","sequence":"first","affiliation":[{"name":"1From the Department of Pediatrics, and Steele Memorial Children's Research Center, University of Arizona, Tucson, Arizona."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Joanne","family":"Hyndman","sequence":"additional","affiliation":[{"name":"1From the Department of Pediatrics, and Steele Memorial Children's Research Center, University of Arizona, Tucson, Arizona."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2000,3,1]]},"reference":[{"key":"2021121003103570300_B1","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1097\/00006454-199306000-00013","article-title":"Hydrocephalus complicating lymphocytic choriomeningitis virus infection.","volume":"12","author":"Larsen","year":"1993","journal-title":"Pediatr Infect Dis J"},{"key":"2021121003103570300_B2","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1097\/00006454-199311000-00010","article-title":"Congenital lymphocytic choriomeningitis virus infection in twins.","volume":"12","author":"Barton","year":"1993","journal-title":"Pediatr Infect Dis 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