{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T15:18:44Z","timestamp":1770477524287,"version":"3.49.0"},"reference-count":45,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,4,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective.<\/jats:title>\n                  <jats:p>To determine whether corticosteroids are efficacious in treating bronchiolitis in hospitalized infants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods.<\/jats:title>\n                  <jats:p>Online bibliographic databases (Medline, Embase, and Cochrane Clinical Trials Registry) were searched for: 1) bronchiolitis or respiratory syncytial virus, and 2) corticosteroid or glucocorticoid or steroidal antiinflammatory agents or adrenal cortex hormones. Reference lists from all selected articles were also examined. Randomized, placebo-controlled trials of systemic corticosteroids in treatment of infants hospitalized with bronchiolitis were selected by 2 investigators. Of 12 relevant publications identified in the literature search, 6 met the selection criteria and had relevant data available. Investigators independently extracted data for 3 outcomes: length of stay (LOS), duration of symptoms (DOS), and clinical scores.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results.<\/jats:title>\n                  <jats:p>In the pooled analysis, infants who received corticosteroids had a mean LOS or DOS that was .43 days less than those who received the placebo treatment (95% confidence interval: \u2212.81 to \u2212.05 days). The effect size for mean clinical score was \u22121.60 (95% confidence interval: \u22121.92 to \u22121.28), favoring treatment. Secondary analyses of mean LOS or DOS were performed on 5 trials that had clearly identified methods of randomization, 5 trials that measured LOS, and 4 trials that clearly excluded infants with previous wheezing. The estimates of effect were similar to the primary analysis but were not statistically significant.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions.<\/jats:title>\n                  <jats:p>Combined, published reports of the effect of systemic corticosteroids on the course of bronchiolitis suggest a statistically significant improvement in clinical symptoms, LOS, and DOS.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.105.4.e44","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T23:50:41Z","timestamp":1092441041000},"page":"e44-e44","source":"Crossref","is-referenced-by-count":139,"title":["Systemic Corticosteroids in Infant Bronchiolitis: A Meta-analysis"],"prefix":"10.1542","volume":"105","author":[{"given":"Michelle M.","family":"Garrison","sequence":"first","affiliation":[{"name":"From the Department of Epidemiology and"},{"name":"Child Health Institute, Seattle, Washington."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitri A.","family":"Christakis","sequence":"additional","affiliation":[{"name":"Division of General Pediatrics, University of Washington; and"},{"name":"Child Health Institute, Seattle, Washington."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Harvey","sequence":"additional","affiliation":[{"name":"Child Health Institute, Seattle, Washington."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Cummings","sequence":"additional","affiliation":[{"name":"From the Department of Epidemiology and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert L.","family":"Davis","sequence":"additional","affiliation":[{"name":"From the Department of Epidemiology and"},{"name":"Division of General Pediatrics, University of Washington; and"},{"name":"Child Health Institute, Seattle, Washington."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2000,4,1]]},"reference":[{"key":"2021121009264561200_B1","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1001\/jama.282.15.1440","article-title":"Bronchiolitis-associated hospitalizations among US children, 1980\u20131996.","volume":"282","author":"Shay","year":"1999","journal-title":"JAMA"},{"key":"2021121009264561200_B2","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1001\/archpedi.1996.02170360056009","article-title":"Efficacy of bronchodilator therapy in bronchiolitis: a meta-analysis.","volume":"150","author":"Kellner","year":"1996","journal-title":"Arch Pediatr Adolesc Med"},{"key":"2021121009264561200_B3","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1542\/peds.100.2.233","article-title":"Efficacy of \u03b22-agonists in bronchiolitis: a reappraisal and meta-analysis.","volume":"100","author":"Flores","year":"1997","journal-title":"Pediatrics"},{"key":"2021121009264561200_B4","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1097\/00006454-199303000-00008","article-title":"Ribavirin effect on pulmonary function in young infants with respiratory syncytial virus bronchiolitis.","volume":"12","author":"Janai","year":"1993","journal-title":"Pediatr Infect Dis J"},{"key":"2021121009264561200_B5","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1136\/adc.61.6.593","article-title":"Ribavirin aerosol for acute bronchiolitis.","volume":"61","author":"Barry","year":"1986","journal-title":"Arch Dis Child"},{"key":"2021121009264561200_B6","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1097\/00006454-199009001-00004","article-title":"New data on clinical efficacy of ribavirin.","volume":"9","author":"Stutman","year":"1990","journal-title":"Pediatr Infect Dis J"},{"key":"2021121009264561200_B7","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1542\/peds.72.5.613","article-title":"Ribavirin aerosol treatment of bronchiolitis associated with respiratory syncytial virus infection in infants.","volume":"72","author":"Taber","year":"1983","journal-title":"Pediatrics"},{"key":"2021121009264561200_B8","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/00006454-199603000-00007","article-title":"Aerosolized immunoglobulin treatment of respiratory syncytial virus infection in infants.","volume":"15","author":"Rimensberger","year":"1996","journal-title":"Pediatr Infect Dis J"},{"key":"2021121009264561200_B9","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1542\/peds.99.3.454","article-title":"Respiratory syncytial virus (RSV) immune globulin intravenous therapy for RSV lower respiratory tract infection in infants and young children at high risk for severe RSV infections. 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