{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T19:33:30Z","timestamp":1777318410893,"version":"3.51.4"},"reference-count":24,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,5,1]]},"abstract":"<jats:p>Ingestion of toxic substances is a common problem in pediatrics. When presented with the limited history of an unknown ingestion in a patient with altered mental status, a clinician depends on the physical examination and a toxic screen to determine the ingested substance(s). Some toxic screens yield false-positive or false-negative results that confound identification of ingested toxins. Three cases are presented in which carbamazepine ingestions were identified because of the false-positive tricyclic antidepressant serum toxic screen result in each case.<\/jats:p>\n               <jats:p>Carbamazepine ingestion is one of the most common pediatric overdoses. Side effects include altered mental status, tachycardia, mydriasis, seizures, coma, and death. Several other substances also cause false-positive tricyclic antidepressant toxic screen results, including certain antipsychotic medications, antihistamines, and the muscle relaxant cyclobenzaprine. Specific tests and drugs causing false-positive results are presented in table form. More modern methods, specifically gas chromatographic-mass spectrometric, are more reliable in distinguishing these drugs. Knowledge of which substances commonly cause false-positive results on a given toxic screen can still lead the clinician to the correct diagnosis. tricyclic, carbamazepine, ingestion, intoxication, drug screen.<\/jats:p>","DOI":"10.1542\/peds.105.5.e66","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T23:50:41Z","timestamp":1092441041000},"page":"e66-e66","source":"Crossref","is-referenced-by-count":26,"title":["False-Positive Tricyclic Antidepressant Drug Screen Results Leading to the Diagnosis of Carbamazepine Intoxication"],"prefix":"10.1542","volume":"105","author":[{"given":"Michael E.","family":"Matos","sequence":"first","affiliation":[{"name":"From the Department of Pediatrics and"},{"name":"Children's Hospital; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele M.","family":"Burns","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics and"},{"name":"Division of Emergency Medicine and Program in Clinical Toxicology, Harvard Medical School;"},{"name":"Children's Hospital; and"},{"name":"Massachusetts Poison Control System, Boston, Massachusetts."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael W.","family":"Shannon","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics and"},{"name":"Division of Emergency Medicine and Program in Clinical Toxicology, Harvard Medical School;"},{"name":"Children's Hospital; and"},{"name":"Massachusetts Poison Control System, Boston, Massachusetts."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2000,5,1]]},"reference":[{"key":"2021121009391450400_B1","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1097\/00008480-199310000-00002","article-title":"Common etiologies and new approaches to management of poisoning in pediatric practice.","volume":"5","author":"Lovejoy","year":"1993","journal-title":"Curr Opin 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