{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T13:10:16Z","timestamp":1772457016047,"version":"3.50.1"},"reference-count":9,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,7,1]]},"abstract":"<jats:title>This Policy Statement was retired October 2006.<\/jats:title>\n               <jats:p>The newborn with abnormal genital development presents a difficult diagnostic and treatment challenge for the primary care pediatrician. It is important that a definitive diagnosis be determined as quickly as possible so that an appropriate treatment plan can be established to minimize medical, psychological, and social complications. The purpose of this review is to identify which newborns among those with abnormal genital development need to be screened for intersexuality, to outline the investigations necessary, and to suggest indications for referral to a center with experience in the diagnosis and management of these disorders. An outline is also presented of the embryology of the external genitalia indicating where errors can arise to provide a framework for pediatricians to use when counseling families. Although the focus of this review is on newborns with what has been termed \u201cambiguous genitalia,\u201d it should be recognized that most genital abnormalities in newborns do not result in an ambiguous appearance. These anomalies include hypospadias, in which the genitalia are clearly malformed, although the sex is unquestionably male.<\/jats:p>","DOI":"10.1542\/peds.106.1.138","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T23:50:41Z","timestamp":1092441041000},"page":"138-142","source":"Crossref","is-referenced-by-count":115,"title":["Evaluation of the Newborn With Developmental Anomalies of the External Genitalia"],"prefix":"10.1542","volume":"106","author":[{"name":"Committee on Genetics","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Section on Endocrinology","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Section on Urology","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2000,7,1]]},"reference":[{"key":"2023081713054184300_B1"},{"key":"2023081713054184300_B2","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0022-5347(17)59004-7","article-title":"The incidence of intersexuality in patients with hypospadias and cryptorchidism.","volume":"116","author":"Rajfer","year":"1976","journal-title":"J Urol."},{"key":"2023081713054184300_B3","first-page":"156","article-title":"Micropenis 1. Criteria, etiologies and classification.","volume":"146","author":"Lee","year":"1980","journal-title":"Johns Hopkins Med J."},{"key":"2023081713054184300_B4","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1542\/pir.17.6.213","article-title":"Ambiguous genitalia.","volume":"17","author":"Anhalt","year":"1996","journal-title":"Pediatr Rev."},{"key":"2023081713054184300_B5","first-page":"30","article-title":"Evaluation of the infant who has ambiguous genitalia, and principles of operative management.","volume":"5","author":"Donahoe","year":"1996","journal-title":"Semin Pediatr Surg."},{"key":"2023081713054184300_B6","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1111\/j.1464-410X.1985.tb07052.x","article-title":"True hermaphroditism: a review of 41 cases with observations on testicular histology and function.","volume":"57","author":"Aaronson","year":"1985","journal-title":"Br J Urol."},{"key":"2023081713054184300_B7","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.2307\/1131303","article-title":"Androgen and the development of human sex-typical behavior: rough-and-tumble play and sex of preferred playmates in children with congenital adrenal hyperplasia (CAH).","volume":"65","author":"Hines","year":"1994","journal-title":"Child Dev."},{"key":"2023081713054184300_B8","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1001\/archpedi.1997.02170470078014","article-title":"Sex assignment in the neonate with intersex or inadequate genitalia.","volume":"151","author":"Reiner","year":"1997","journal-title":"Arch Pediatr Adolesc Med."},{"key":"2023081713054184300_B9","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1001\/archpedi.1997.02170470080015","article-title":"Management of intersexuality: guidelines for dealing with persons with ambiguous genitalia.","volume":"151","author":"Diamond","year":"1997","journal-title":"Arch Pediatr Adolesc Med."}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/106\/1\/138\/1519566\/138.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/106\/1\/138\/1519566\/138.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T13:07:10Z","timestamp":1692277630000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/106\/1\/138\/62819\/Evaluation-of-the-Newborn-With-Developmental"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7,1]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2000,7,1]]},"published-print":{"date-parts":[[2000,7,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.106.1.138","relation":{},"ISSN":["1098-4275","0031-4005"],"issn-type":[{"value":"1098-4275","type":"electronic"},{"value":"0031-4005","type":"print"}],"subject":[],"published":{"date-parts":[[2000,7,1]]}}}