{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:06:42Z","timestamp":1790485602723,"version":"4.1.0"},"reference-count":21,"publisher":"American Academy of Pediatrics (AAP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,8,1]]},"abstract":"<jats:sec><jats:title>Objectives.<\/jats:title><jats:p>The aims of the study were to establish the relationship between head growth in the first year of life with the pattern on injury on neonatal magnetic resonance imaging (MRI) in infants with hypoxic\u2013ischemic encephalopathy (HIE) and to relate these to the neurodevelopmental outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Fifty-two term infants who presented at birth with a neonatal encephalopathy consistent with HIE and who had neonatal brain MRI were entered into the study. Head circumference charts were evaluated retrospectively and the head growth over the first year of life compared with the pattern of brain lesions on MRI and with the neurodevelopmental outcome at 1 year of age. Suboptimal head growth was classified as a drop of &amp;gt;2 standard deviations across the percentiles with or without the development of microcephaly, which was classified as a head circumference below the third percentile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>There was no statistical difference between the neonatal head circumferences of the infants presenting with HIE and control infants. At 12 months, microcephaly was present in 48% of the infants with HIE, compared with 3% of the controls. Suboptimal head growth was documented in 53% of the infants with HIE, compared with 3% of the controls. Suboptimal head growth was significantly associated with the pattern of brain lesions, in particular to involvement of severe white matter and to severe basal ganglia and thalamic lesions. Suboptimal head growth predicted abnormal neurodevelopmental outcome with a sensitivity of 79% and a specificity of 78%, compared with the presence of microcephaly at 1 year of age, which had a sensitivity of only 65% and a specificity of 73%. The exceptions were explained by infants with only moderate white matter abnormalities who had suboptimal head growth but normal outcome at 1 year of age and by infants with moderate basal ganglia and thalamic lesions only who had normal head growth but significant motor abnormality.<\/jats:p><\/jats:sec>","DOI":"10.1542\/peds.106.2.235","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T23:50:41Z","timestamp":1092441041000},"page":"235-243","source":"Crossref","is-referenced-by-count":99,"title":["Head Growth in Infants With Hypoxic\u2013Ischemic Encephalopathy: Correlation With Neonatal Magnetic Resonance Imaging"],"prefix":"10.1542","volume":"106","author":[{"given":"Eugenio","family":"Mercuri","sequence":"first","affiliation":[{"name":"From the Department of Paediatrics and Child Health and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Ricci","sequence":"additional","affiliation":[{"name":"From the Department of Paediatrics and Child Health and"},{"name":"Department of Paediatric Neurology and Psychiatry, Catholic University, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances M.","family":"Cowan","sequence":"additional","affiliation":[{"name":"From the Department of Paediatrics and Child Health and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniella","family":"Lessing","sequence":"additional","affiliation":[{"name":"From the Department of Paediatrics and Child Health and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria F.","family":"Frisone","sequence":"additional","affiliation":[{"name":"From the Department of Paediatrics and Child Health and"},{"name":"Department of Paediatric Neurology and Psychiatry, Catholic University, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leena","family":"Haataja","sequence":"additional","affiliation":[{"name":"From the Department of Paediatrics and Child Health and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena J.","family":"Counsell","sequence":"additional","affiliation":[{"name":"Robert Steiner Magnetic Resonance Unit, Imperial College of Science, Technology and Medicine, Hammersmith Campus, London, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilly M.","family":"Dubowitz","sequence":"additional","affiliation":[{"name":"From the Department of Paediatrics and Child Health and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary A.","family":"Rutherford","sequence":"additional","affiliation":[{"name":"From the Department of Paediatrics and Child Health and"},{"name":"Robert Steiner Magnetic Resonance Unit, Imperial College of Science, Technology and Medicine, Hammersmith Campus, London, United Kingdom; 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