{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T07:13:45Z","timestamp":1770794025506,"version":"3.50.0"},"reference-count":35,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,12,1]]},"abstract":"\n Objective.<\/jats:title>\n To evaluate the influence of early antiinflammatory therapy in the development of asthma 3 years after hospitalization for wheezing in infancy. In addition, the effects of allergic sensitization and respiratory syncytial virus (RSV) infection on the development of asthma were investigated.<\/jats:p>\n <\/jats:sec>\n \n Design and Setting.<\/jats:title>\n A randomized, controlled follow-up study in a university hospital that provides primary hospital care for all pediatric patients in a defined area.<\/jats:p>\n <\/jats:sec>\n \n Patients.<\/jats:title>\n Eighty-nine infants under 2 years of age who had been hospitalized for infection associated with wheezing and followed up for 3 years.<\/jats:p>\n <\/jats:sec>\n \n Intervention.<\/jats:title>\n Early antiinflammatory therapy was given for 16 weeks; 29 patients received cromolyn sodium and 31 received budesonide. Twenty-nine control patients received no therapy.<\/jats:p>\n <\/jats:sec>\n \n Outcome Measures.<\/jats:title>\n Clinical diagnosis of current asthma, defined as having at least 3 episodes of physician-diagnosed wheezing and either a wheezing episode during the preceding year or ongoing antiinflammatory medication for asthma.<\/jats:p>\n <\/jats:sec>\n \n Results.<\/jats:title>\n Fourteen (48%) patients in the former cromolyn group, 15 (48%) in the former budesonide group, and 16 (55%) in the control group had current asthma. The significant predictors of asthma were age over 12 months (risk ratio [RR] 4.1; 95% confidence interval [CI] = 1.59\u201310.35), history of wheezing (RR 6.8; CI = 1.35\u201334.43), and atopic dermatitis on study entry (RR 3.4; CI = 1.17\u20139.39). Skin prick test positivity at the age of 16 months significantly predicted asthma (RR 9.5; CI = 2.45\u201336.72). In addition, all of the 18 (20%) children sensitized with furred pet developed asthma. RSV identification (RR 0.3; CI = 0.08\u20130.80) and early furred pet contact at home (RR 0.3; CI 0.10\u20130.79) were associated with the decreased occurrence of asthma.<\/jats:p>\n <\/jats:sec>\n \n Conclusions.<\/jats:title>\n Antiinflammatory therapy for 4 months has no influence on the occurrence of asthma 3 years after wheezing in infancy. Early sensitization to indoor allergens, especially to pets, and atopic dermatitis predict subsequent development of asthma. RSV infection in wheezing infants may have a better outcome than other infections.<\/jats:p>\n <\/jats:sec>","DOI":"10.1542\/peds.106.6.1406","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T23:50:41Z","timestamp":1092441041000},"page":"1406-1412","source":"Crossref","is-referenced-by-count":106,"title":["Predictors of Asthma Three Years After Hospital Admission for Wheezing in Infancy"],"prefix":"10.1542","volume":"106","author":[{"given":"Tiina Marjaana","family":"Reijonen","sequence":"first","affiliation":[{"name":"1 From the Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland. Presented in part at the European Respiratory Society Annual Congress, Geneva, Switzerland, September 19\u201323, 1998."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Kotaniemi-Syrja\u0308nen","sequence":"additional","affiliation":[{"name":"1 From the Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland. Presented in part at the European Respiratory Society Annual Congress, Geneva, Switzerland, September 19\u201323, 1998."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaj","family":"Korhonen","sequence":"additional","affiliation":[{"name":"1 From the Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland. Presented in part at the European Respiratory Society Annual Congress, Geneva, Switzerland, September 19\u201323, 1998."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matti","family":"Korppi","sequence":"additional","affiliation":[{"name":"1 From the Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland. Presented in part at the European Respiratory Society Annual Congress, Geneva, Switzerland, September 19\u201323, 1998."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2000,12,1]]},"reference":[{"key":"2021121003310717900_B1","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1136\/adc.58.9.713","article-title":"Respiratory problems 2 years after acute bronchiolitis in infancy.","volume":"58","author":"Henry","year":"1983","journal-title":"Arch Dis Child."},{"key":"2021121003310717900_B2","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/ppul.1950070307","article-title":"Childhood asthma following hospitalization with acute viral bronchiolitis in infancy.","volume":"7","author":"Sly","year":"1989","journal-title":"Pediatr Pulmonol."},{"key":"2021121003310717900_B3","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1001\/archpedi.1994.02170100077015","article-title":"Bronchial asthma and 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