{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:31:26Z","timestamp":1791091886907,"version":"4.1.0"},"reference-count":62,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,12,1]]},"abstract":"<jats:sec>\n                  <jats:title>Context.<\/jats:title>\n                  <jats:p>The newly licensed tetravalent rhesus-human reassortant rotavirus vaccine has been withdrawn following reports of intussusception among vaccinated infants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective.<\/jats:title>\n                  <jats:p>To describe the epidemiology of intussusception-associated hospitalizations and deaths among US infants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design.<\/jats:title>\n                  <jats:p>This retrospective cohort study examined hospital discharge data from the National Hospital Discharge Survey for 1988\u20131997, Indian Health Service (IHS) for 1980\u20131997, California for 1990\u20131997, Indiana for 1994\u20131998, Georgia for 1997\u20131998, and MarketScan for 1993\u20131996, and mortality data from the national multiple cause-of-death data for 1979\u20131997 and linked birth\/infant death data for 1995\u20131997.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients.<\/jats:title>\n                  <jats:p>Infants (&amp;lt;1 year old) with anInternational Classification of Diseases, Ninth Revision, Clinical Modification code for intussusception (560.0) listed on their hospital discharge or mortality record, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results.<\/jats:title>\n                  <jats:p>During 1994\u20131996, annual rates for intussusception-associated infant hospitalization varied among the data sets, being lowest for the IHS (18 per 100\u2009000; 95% confidence interval [CI] = 9\u201335 per 100\u2009000) and greatest for the National Hospital Discharge Survey (56 per 100\u2009000; 95% CI = 33\u201379 per 100\u2009000) data sets. Rates among IHS infants declined from 87 per 100\u2009000 during 1980\u20131982 to 12 per 100\u2009000 during 1995\u20131997 (relative risk =7.6, 95% CI = 3.2\u201318.2). Intussusception-associated hospitalizations were uncommon in the first 2 months of life, peaked from 5 to 7 months old, and showed no consistent seasonality. Intussusception-associated infant mortality rates declined from 6.4 per 1\u2009000\u2009000 live births during 1979\u20131981 to 2.3 per 1\u2009000\u2009000 live births during 1995\u20131997 (relative risk = 2.8, 95% CI = 1.8\u20134.3). Infants whose mothers were &amp;lt;20 years old, nonwhite, unmarried, and had an education level below grade 12 years were at an increased risk for intussusception-associated death.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions.<\/jats:title>\n                  <jats:p>Intussusception-associated hospitalization rates varied among the data sets and decreased substantially over time in the IHS data. Although intussusception-associated infant deaths in the United States have declined substantially over the past 2 decades, some deaths seem to be related to reduced access to, or delays in seeking, health care and are potentially preventable.intussusception, hospitalizations, deaths, risk factors, infants.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.106.6.1413","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T23:50:41Z","timestamp":1092441041000},"page":"1413-1421","source":"Crossref","is-referenced-by-count":188,"title":["Trends in Intussusception-Associated Hospitalizations and Deaths Among US Infants"],"prefix":"10.1542","volume":"106","author":[{"given":"Umesh D.","family":"Parashar","sequence":"first","affiliation":[{"name":"From the Viral Gastroenteritis Section, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, Georgia;"},{"name":"Preventive Medicine Residency Program, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Holman","sequence":"additional","affiliation":[{"name":"Office of the Director, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate C.","family":"Cummings","sequence":"additional","affiliation":[{"name":"Disease Investigations and Surveillance Branch, Division of Communicable Disease Control, California Department of Health Services, Berkeley, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Wayne","family":"Staggs","sequence":"additional","affiliation":[{"name":"Epidemiology Resource Center, Indiana State Department of Health, Indianapolis, Indiana;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron T.","family":"Curns","sequence":"additional","affiliation":[{"name":"Office of the Director, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"From the Viral Gastroenteritis Section, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen F.","family":"Kaufman","sequence":"additional","affiliation":[{"name":"Indian Health Service, US Department of Health and Human Services, Rockville, Maryland; and the"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon E.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Epidemiology Resource Center, Indiana State Department of Health, Indianapolis, Indiana;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duc J.","family":"Vugia","sequence":"additional","affiliation":[{"name":"Disease Investigations and Surveillance Branch, Division of Communicable Disease Control, California Department of Health Services, Berkeley, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth E.","family":"Powell","sequence":"additional","affiliation":[{"name":"Division of Public Health, Georgia Department of Human Resources, Atlanta, Georgia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger I.","family":"Glass","sequence":"additional","affiliation":[{"name":"From the Viral Gastroenteritis Section, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2000,12,1]]},"reference":[{"key":"2021121003305665300_B1","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1002\/bjs.1800790906","article-title":"Paediatric intussusception.","volume":"79","author":"Stringer","year":"1992","journal-title":"Br J Surg."},{"key":"2021121003305665300_B2","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/S1055-8586(99)70029-6","article-title":"Intussusception.","volume":"8","author":"DiFiore","year":"1999","journal-title":"Semin Pediatr Surg."},{"key":"2021121003305665300_B3","first-page":"73","article-title":"Intussusception in infants: an emergency in diagnosis and treatment.","volume":"6","author":"Roeyen","year":"1999","journal-title":"Eur J Emerg 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diverticulum in Amsterdam: experience in 136 patients.","volume":"19","author":"Bemelman","year":"1995","journal-title":"World J Surg."},{"key":"2021121003305665300_B8","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s003830050479","article-title":"Postoperative intussusception in childhood.","volume":"14","author":"Linke","year":"1998","journal-title":"Pediatr Surg Int."},{"key":"2021121003305665300_B9","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1097\/00007611-199111000-00010","article-title":"Postoperative intussusception: increasing frequency or increasing awareness?","volume":"84","author":"Holcomb","year":"1991","journal-title":"South Med J."},{"key":"2021121003305665300_B10","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0140-6736(62)92315-2","article-title":"Adenovirus infection in association with intussusception in 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Taiwan.","volume":"208","author":"Clarke","year":"1969","journal-title":"JAMA."},{"key":"2021121003305665300_B14","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/jmv.1890020310","article-title":"Human rotavirus infection in infants and young children with intussusception.","volume":"2","author":"Konno","year":"1978","journal-title":"J Med Virol."},{"key":"2021121003305665300_B15","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/jmv.1890090404","article-title":"A one-year virological survey of acute intussusception in childhood.","volume":"9","author":"Nicholas","year":"1982","journal-title":"J Med Virol."},{"key":"2021121003305665300_B16","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/jmv.1890090108","article-title":"A two-part study of the aetiological role of rotavirus in intussusception.","volume":"9","author":"Mulcahy","year":"1982","journal-title":"J Med 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