{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T13:15:06Z","timestamp":1746710106592,"version":"3.40.5"},"reference-count":27,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,4,1]]},"abstract":"\n Objective.<\/jats:title>\n The investigation examined the associations of plasma human immunodeficiency virus (HIV) RNA and CD4+ T lymphocytes with height, weight, skeletal maturation, testosterone levels, and height velocity for hemophilic children and adolescents with HIV infection in the Hemophilia Growth and Development Study.<\/jats:p>\n <\/jats:sec>\n \n Study Design.<\/jats:title>\n Two hundred seven participants were evaluated over 7 years.<\/jats:p>\n <\/jats:sec>\n \n Results.<\/jats:title>\n A threefold increment in baseline plasma HIV RNA was associated with a 0.98-cm decrease in height and a 1.67-kg decrease in weight; 100-cells\/\u03bcL decrements in baseline CD4+ were associated with a 2.51-cm decrease in height and a 3.83-kg decrease in weight. Participants with high plasma HIV RNA (&gt;3125 copies\/mL) experienced significant delay in achieving maximum height velocity and lower maximum velocity compared with those with low viral load. The high CD4+ (&gt;243)\/low plasma HIV RNA group had earlier age at maximum height velocity compared with the other 3 groups and higher maximum height velocity compared with the low CD4+\/high plasma HIV RNA and low CD4+\/low plasma HIV RNA groups. Decrements in CD4+ were associated with decreases in bone age and testosterone level.<\/jats:p>\n <\/jats:sec>\n \n Conclusions.<\/jats:title>\n CD4+ and HIV RNA were important in predicting growth outcomes.<\/jats:p>\n <\/jats:sec>","DOI":"10.1542\/peds.107.4.e56","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T23:55:51Z","timestamp":1092441351000},"page":"e56-e56","source":"Crossref","is-referenced-by-count":7,"title":["The Effect of Plasma Human Immunodeficiency Virus RNA and CD4+ T Lymphocytes on Growth Measurements of Hemophilic Boys and Adolescents"],"prefix":"10.1542","volume":"107","author":[{"given":"Margaret W.","family":"Hilgartner","sequence":"first","affiliation":[{"name":"From the Division of Pediatric Hematology and Oncology, New York Presbyterian Hospital-Cornell Medical Center, New York, New York;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharyne M.","family":"Donfield","sequence":"additional","affiliation":[{"name":"Rho, Incorporated, Chapel Hill, North Carolina;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry S.","family":"Lynn","sequence":"additional","affiliation":[{"name":"Rho, Incorporated, Chapel Hill, North Carolina;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. Keith","family":"Hoots","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Internal Medicine, University of Texas Health Science Center, Houston, Texas;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward D.","family":"Gomperts","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Childrens Hospital Los Angeles, Los Angeles, California;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric S.","family":"Daar","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Cedars-Sinai Burns and Allen Research Institute, Los Angeles, California; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Chernoff","sequence":"additional","affiliation":[{"name":"Chiron Corporation, Emeryville, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunny K.","family":"Pearson","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Childrens Hospital Los Angeles, Los Angeles, California;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Hemophilia Growth and Development Study","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2001,4,1]]},"reference":[{"key":"2021121003444022500_B1","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1097\/00043426-199305000-00009","article-title":"Hemophilia Growth and Development Study: design, methods, and entry data.","volume":"15","author":"Hilgartner","year":"1993","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"2021121003444022500_B2","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0022-3476(05)83177-4","article-title":"Delayed somatic growth and pubertal development in human immunodeficiency virus positive hemophiliac boys: 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