{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:06:40Z","timestamp":1791320800322,"version":"4.3.1"},"reference-count":12,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,5,1]]},"abstract":"<jats:p>Apnea of prematurity (AOP) is frequently managed with nasal continuous positive airway pressure (NCPAP). Nasal cannula (NC) are used at low flows (&amp;lt;0.5 L\/min) to deliver supplemental oxygen to neonates. A number of centers use high-flow nasal cannula (HFNC) in the management of AOP without measuring the positive distending pressure (PDP) generated.<\/jats:p><jats:p>Objective.\u2003To determine the NC flow required to generate PDP equal to that provided by NCPAP at 6 cm H2O and to assess the effectiveness of HFNC as compared NCPAP in the management of AOP.<\/jats:p><jats:p>Method.\u2003Forty premature infants, gestation 28.7 \u00b1 0.4 weeks (mean \u00b1 standard error of mean), postconceptual age at study 30.3 \u00b1 0.6 weeks, birth weight 1256 \u00b1 66 g, study weight 1260 \u00b1 63 g who were being managed with conventional NCPAP for at least 24 hours for clinically significant apnea of prematurity, were enrolled in a trial of ventilator-generated conventional NCPAP versus infant NC at flows of up to 2.5 L\/min. End expiratory esophageal pressure was measured on NCPAP and on NC, and the gas flow on NC was adjusted to generate an end expiratory esophageal pressure equal to that measured on NCPAP. Two 6-hour periods were continuously recorded and the data were stored on computer.<\/jats:p><jats:p>Results.\u2003The flow required to generate a comparable PDP with NC varied with the infant's weight and was represented by the equation: flow (L\/min) = 0.92 + 0.68x, x = weight in kg,R = 0.72. There was no difference in the frequency and duration of apnea, bradycardia or desaturation per recording between the 2 systems.<\/jats:p><jats:p>Conclusion.\u2003NC at flows of 1 to 2.5 L\/min can deliver PDP in premature neonates. HFNC is as effective as NCPAP in the management of AOP.<\/jats:p>","DOI":"10.1542\/peds.107.5.1081","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T23:55:51Z","timestamp":1092441351000},"page":"1081-1083","source":"Crossref","is-referenced-by-count":293,"title":["High-Flow Nasal Cannulae in the Management of Apnea of Prematurity: A Comparison With Conventional Nasal Continuous Positive Airway Pressure"],"prefix":"10.1542","volume":"107","author":[{"given":"Con","family":"Sreenan","sequence":"first","affiliation":[{"name":"From the Neonatal Intensive Care Unit, Royal Alexandra Hospital; and the"},{"name":"Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"Lemke","sequence":"additional","affiliation":[{"name":"From the Neonatal Intensive Care Unit, Royal Alexandra Hospital; and the"},{"name":"Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Hudson-Mason","sequence":"additional","affiliation":[{"name":"From the Neonatal Intensive Care Unit, Royal Alexandra Hospital; 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