{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:10:42Z","timestamp":1791889842860,"version":"4.3.4"},"reference-count":14,"publisher":"American Academy of Pediatrics (AAP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective.<\/jats:title>\n                    <jats:p>Continuous venovenous hemofiltration (CVVH) alone or with dialysis (D) has become an important supportive therapy for critically ill children with acute renal failure. Previous reports of pediatric patient outcome either mix CVVH\/D with other renal replacement modalities or do not examine severity of illness. The current study examines only outcomes of children receiving CVVH\/D using Pediatric Risk of Mortality (PRISM) scores to control for severity of illness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients.<\/jats:title>\n                    <jats:p>Twenty-one patients (mean age: 8.8 \u00b1 6.3 years; mean weight: 28.3 \u00b1 20.8 kg) received 22 courses of CVVH\/D.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcomes.<\/jats:title>\n                    <jats:p>Nine (42.8%) of 21 patients survived. Nine (75%) of 12 deaths occurred within 25 days of pediatric intensive care unit (PICU) admission. Mean PRISM score at PICU admission and CVVH initiation were 13.1 \u00b1 5.8 and 15.4 \u00b1 8.9, respectively. Mean patient weight, age, PRISM score at PICU admission and at CVVH\/D initiation, maximum pressor number, estimated glomerular filtration rate at CVVH\/D initiation and change in mean airway pressure did not differ between survivors and nonsurvivors. The degree of fluid overload at CVVH\/D initiation was significantly lower in survivors (16.4% \u00b1 13.8%) compared with nonsurvivors (34.0% \u00b1 21.0%), even when controlled for severity of illness by PRISM score. Mean cost of providing CVVH\/D accounted for only 1% of total PICU cost per patient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions.<\/jats:title>\n                    <jats:p>The pattern of early multiorgan system failure and death, minimal relative cost of CVVH\/D provision, and potential for improved outcome with initiation of CVVH\/D at lesser degrees of fluid overload are factors that may support early initiation of CVVH\/D in critically ill children with acute renal failure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1542\/peds.107.6.1309","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T19:55:51Z","timestamp":1092426951000},"page":"1309-1312","source":"Crossref","is-referenced-by-count":497,"title":["Outcome in Children Receiving Continuous Venovenous Hemofiltration"],"prefix":"10.1542","volume":"107","author":[{"given":"Stuart L.","family":"Goldstein","sequence":"first","affiliation":[{"name":"From the Department of Pediatrics, Renal Section, Baylor College of Medicine;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Currier","sequence":"additional","affiliation":[{"name":"Texas Children's Hospital Renal Dialysis Unit; and the"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanine M.","family":"Graf","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Critical Care Section, Baylor College of Medicine, Houston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen C.","family":"Cosio","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Critical Care Section, Baylor College of Medicine, Houston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen D.","family":"Brewer","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, Renal Section, Baylor College of Medicine;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Sachdeva","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Critical Care Section, Baylor College of Medicine, Houston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2001,6,1]]},"reference":[{"key":"2021121009494859800_B1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/BF02254215","article-title":"Dialytic management of childhood acute renal failure: a survey of North American pediatric nephrologists.","volume":"9","author":"Belsha","year":"1995","journal-title":"Pediatr Nephrol"},{"key":"2021121009494859800_B2","first-page":"613","article-title":"Outcome of dialysis for acute renal failure in pediatric bone marrow transplant patients.","volume":"13","author":"Lane","year":"1994","journal-title":"Bone Marrow Transplant"},{"key":"2021121009494859800_B3","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1681\/ASN.V651401","article-title":"Determinants of survival in pediatric continuous hemofiltration.","volume":"6","author":"Smoyer","year":"1995","journal-title":"J Am Soc Nephrol"},{"key":"2021121009494859800_B4","doi-asserted-by":"crossref","first-page":"S84","DOI":"10.1016\/S0272-6386(97)90547-3","article-title":"Management of acute renal failure in the pediatric patient: hemofiltration versus hemodialysis.","volume":"30","author":"Maxvold","year":"1997","journal-title":"Am J Kidney Dis"},{"key":"2021121009494859800_B5","first-page":"14","article-title":"Clinical scoring systems in children with continuous extracorporeal renal support.","volume":"10","author":"Zobel","year":"1990","journal-title":"Child Nephrol Urol"},{"key":"2021121009494859800_B6","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1097\/00003246-198811000-00006","article-title":"Pediatric risk of mortality (PRISM) score.","volume":"16","author":"Pollack","year":"1988","journal-title":"Crit Care Med"},{"key":"2021121009494859800_B7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0272-6386(95)90618-5","article-title":"Continuous venovenous hemodiafiltration in infants and children.","volume":"25","author":"Bunchman","year":"1995","journal-title":"Am J Kidney Dis"},{"key":"2021121009494859800_B8","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/BF00868282","article-title":"Continuous arterial-venous diahemofiltration and continuous veno-venous diahemofiltration in infants and children.","volume":"8","author":"Bunchman","year":"1994","journal-title":"Pediatr Nephrol"},{"key":"2021121009494859800_B9","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/00003246-198603000-00010","article-title":"Dynamic assessment of severity of illness in pediatric intensive care.","volume":"14","author":"Ruttimann","year":"1986","journal-title":"Crit Care Med"},{"key":"2021121009494859800_B10","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/BF01213327","article-title":"Limitations of the pediatric risk of mortality score in assessing children with acute renal failure.","volume":"7","author":"Fargason","year":"1994","journal-title":"Pediatr Nephrol"},{"key":"2021121009494859800_B11","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1093\/ndt\/11.7.1250","article-title":"Does continuous renal replacement therapy favourably influence the outcome of the patients?","volume":"11","author":"Jakob","year":"1996","journal-title":"Nephrol Dial Transplant"},{"key":"2021121009494859800_B12","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1097\/00003246-199406000-00023","article-title":"Timing and predictors of death in pediatric patients with multiple organ system failure.","volume":"22","author":"Proulx","year":"1994","journal-title":"Crit Care Med"},{"key":"2021121009494859800_B13","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1378\/chest.109.4.1033","article-title":"Epidemiology of sepsis and multiple organ dysfunction syndrome in children.","volume":"109","author":"Proulx","year":"1996","journal-title":"Chest"},{"key":"2021121009494859800_B14","first-page":"337","article-title":"Continuous venovenous hemofiltration: a cost-effective therapy for the pediatric patient.","volume":"24","author":"Gilman","year":"1997","journal-title":"Am Neurol Nurs Assoc J."}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/107\/6\/1309\/895597\/1309.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/107\/6\/1309\/895597\/1309.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T16:53:43Z","timestamp":1639155223000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/107\/6\/1309\/66311\/Outcome-in-Children-Receiving-Continuous"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6,1]]},"references-count":14,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2001,6,1]]},"published-print":{"date-parts":[[2001,6,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.107.6.1309","relation":{},"ISSN":["1098-4275","0031-4005"],"issn-type":[{"value":"1098-4275","type":"electronic"},{"value":"0031-4005","type":"print"}],"subject":[],"published":{"date-parts":[[2001,6,1]]}}}