{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:16:56Z","timestamp":1788959816698,"version":"build-2803163510"},"reference-count":31,"publisher":"American Academy of Pediatrics (AAP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,7,1]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>To determine whether synchronized nasal intermittent positive pressure ventilation (SNIPPV) would decrease extubation failure compared with nasal continuous positive airway pressure (NCPAP) in preterm infants being ventilated for respiratory distress syndrome (RDS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Infants who were \u226434 weeks' gestational age and who were ventilated for RDS were randomized to either SNIPPV or NCPAP after extubation. The criteria for extubation were peak inspiratory pressure of \u226416 cm H2O, positive end expiratory pressure of \u22645 cm H2O, intermittent mandatory ventilation rate of 15 to 25, and fraction of inspired oxygen \u22640.35. Pulmonary function tests (PFT) were obtained before extubation. After extubation, blood gases were monitored for a minimum of 72 hours. Success was defined as remaining in the selected mode of treatment or demonstrating improvement (switching to oxyhood\/nasal cannula\/room air) by 72 hours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Thirty-two (94%) of 34 infants were extubated successfully with the use of SNIPPV versus 18 (60%) of 30 with the use of NCPAP (P &amp;lt; .01). There was no difference in apnea\/bradycardia episodes in the 2 groups during the 72-hour study period. Among 55 infants who had PFT, 80% (8 of 10) with dynamic lung compliance of \u22650.5 mL\/kg\/cm H2O and expiratory airway resistance of \u226470 cm H2O\/L\/s were extubated successfully. In infants with poor lung function (dynamic lung compliance: &amp;lt;0.5 mL\/kg\/cm H2O; expiratory airway resistance: &amp;gt;70 cm H2O\/L\/s), successful extubation was seen in 93% (27 of 29) in the SNIPPV group and 60% (15 of 25) in the NCPAP group. When weight was controlled for at the time of extubation, the odds of success in the SNIPPV group were 21.1 times higher (95% confidence interval: 3.4, 130.1) than that of the NCPAP group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions.<\/jats:title><jats:p>SNIPPV is more effective than NCPAP in weaning infants with RDS from the ventilator. PFT may be useful in predicting successful extubation.<\/jats:p><\/jats:sec>","DOI":"10.1542\/peds.108.1.13","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T23:55:51Z","timestamp":1092441351000},"page":"13-17","source":"Crossref","is-referenced-by-count":163,"title":["A Prospective Randomized, Controlled Trial Comparing Synchronized Nasal Intermittent Positive Pressure Ventilation Versus Nasal Continuous Positive Airway Pressure as Modes of Extubation"],"prefix":"10.1542","volume":"108","author":[{"given":"M.\u2009Nabeel","family":"Khalaf","sequence":"first","affiliation":[{"name":"From the Departments of Pediatrics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Brodsky","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatrics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Hurley","sequence":"additional","affiliation":[{"name":"Respiratory Care, Albert Einstein Medical Center, Philadelphia, Pennsylvania."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vineet","family":"Bhandari","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatrics and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2001,7,1]]},"reference":[{"key":"2021121011015453200_B1","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1001\/archpedi.1982.03970400077020","article-title":"Postextubation nasal continuous positive airway pressure.","volume":"136","author":"Engelke","year":"1982","journal-title":"Am J Dis Child"},{"key":"2021121011015453200_B2","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1542\/peds.88.5.999","article-title":"Nasal continuous positive airway pressure facilitates extubation of very low birth weight neonates.","volume":"88","author":"Higgins","year":"1991","journal-title":"Pediatrics"},{"key":"2021121011015453200_B3","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1136\/adc.68.5_Spec_No.570","article-title":"Randomized trial of methods of extubation in acute and chronic respiratory distress.","volume":"68","author":"Chan","year":"1993","journal-title":"Arch Dis Child"},{"key":"2021121011015453200_B4","doi-asserted-by":"crossref","first-page":"F191","DOI":"10.1136\/fn.72.3.F191","article-title":"Application of nasal continuous positive airway pressure to early extubation in very low birth weight infants.","volume":"72","author":"So","year":"1995","journal-title":"Arch Dis Child"},{"key":"2021121011015453200_B5","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/ppul.1950190505","article-title":"Does continuous positive airway pressure during weaning from intermittent mandatory ventilation in very low birth weight infants have risks or benefits? 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