{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:25:35Z","timestamp":1787984735712,"version":"build-2784847793"},"reference-count":26,"publisher":"American Academy of Pediatrics (AAP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,9,1]]},"abstract":"<jats:p>Scurvy has been known since ancient times, but the discovery of the link between the dietary deficiency of ascorbic acid and scurvy has dramatically reduced its incidence over the past half-century. Sporadic reports of scurvy still occur, primarily in elderly, isolated individuals with alcoholism. The incidence of scurvy in the pediatric population is very uncommon, and it is usually seen in children with severely restricted diets attributable to psychiatric or developmental problems. The condition is characterized by perifollicular petechiae and bruising, gingival inflammation and bleeding, and, in children, bone disease. We describe a case of scurvy in a 9-year-old developmentally delayed girl who had a diet markedly deficient in vitamin C resulting from extremely limited food preferences. She presented with debilitating bone pain, inflammatory gingival disease, perifollicular hyperkeratosis, and purpura. Severe hypertension without another apparent secondary cause was also present, which has been previously undescribed. The signs of scurvy and hypertension resolved after treatment with vitamin C. The diagnosis of scurvy is made on clinical and radiographic grounds, and may be supported by finding reduced levels of vitamin C in serum or buffy-coat leukocytes. The response to vitamin C is dramatic. Clinicians should be aware of this potentially fatal but easily curable condition that is still occasionally encountered among children.<\/jats:p>","DOI":"10.1542\/peds.108.3.e55","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T19:55:51Z","timestamp":1092426951000},"page":"e55-e55","source":"Crossref","is-referenced-by-count":215,"title":["An Orange a Day Keeps the Doctor Away: Scurvy in the Year 2000"],"prefix":"10.1542","volume":"108","author":[{"given":"Michael","family":"Weinstein","sequence":"first","affiliation":[{"name":"From the Departments of Paediatrics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Babyn","sequence":"additional","affiliation":[{"name":"Radiology, Hospital for Sick Children and University of Toronto, Toronto, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stan","family":"Zlotkin","sequence":"additional","affiliation":[{"name":"From the Departments of Paediatrics and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2001,9,1]]},"reference":[{"key":"2021121010015393800_B1","first-page":"842","article-title":"New concepts in the biology and biochemistry of ascorbic acid.","volume":"314","author":"Levine","year":"1986","journal-title":"N Engl J Med"},{"key":"2021121010015393800_B2"},{"key":"2021121010015393800_B3"},{"key":"2021121010015393800_B4"},{"key":"2021121010015393800_B5","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1001\/archpedi.154.7.732","article-title":"Scurvy presenting as painful gait with bruising in a young boy.","volume":"154","author":"Tamura","year":"2000","journal-title":"Arch Pediatr Adolesc Med"},{"key":"2021121010015393800_B6","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0140-6736(97)10235-5","article-title":"A boy with a limp.","volume":"351","author":"Shetty","year":"1998","journal-title":"Lancet"},{"key":"2021121010015393800_B7","first-page":"493","article-title":"Capillary hemorrhage in ascorbic-acid-deficient guinea pigs: ultrastructural basis.","volume":"85","author":"Gone","year":"1968","journal-title":"Arch Pathol"},{"key":"2021121010015393800_B8","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1093\/ajcn\/22.5.535","article-title":"Experimental scurvy in man.","volume":"22","author":"Hodges","year":"1969","journal-title":"Am J Clin Nutr"},{"key":"2021121010015393800_B9"},{"key":"2021121010015393800_B10"},{"key":"2021121010015393800_B11"},{"key":"2021121010015393800_B12"},{"key":"2021121010015393800_B13"},{"key":"2021121010015393800_B14","first-page":"111","article-title":"Scurvy resembling cutaneous vasculitis.","volume":"54","author":"Adelman","year":"1994","journal-title":"Cutis"},{"key":"2021121010015393800_B15","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1177\/095952878306600112","article-title":"On cases described as \u201cacute rickets\u201d which are possibly a combination of rickets and scurvy, the scurvy being essential and the rickets variable.","volume":"66","author":"Barlow","year":"1883","journal-title":"Medico-Chirurgical Transactions"},{"key":"2021121010015393800_B16","doi-asserted-by":"crossref","first-page":"4763","DOI":"10.1016\/S0021-9258(18)97021-3","article-title":"3,4-Dihydroxyphenylethylamine P-hydroxylase.","volume":"240","author":"Friedman","year":"1965","journal-title":"J Biol Chem"},{"key":"2021121010015393800_B17","first-page":"343","article-title":"Inverse association of serum ascorbic acid level and blood pressure or rate of hypertension in male adults aged 30\u201339 years.","volume":"54","author":"Yoshiko","year":"1984","journal-title":"Int J Vitam Nutr Res"},{"key":"2021121010015393800_B18","first-page":"1071","article-title":"Vitamin C and lowering of blood pressure: need for intervention trials? [letter; comment].","volume":"8","author":"Hemila","year":"1990","journal-title":"J Hypertens"},{"key":"2021121010015393800_B19","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/cvr\/16.10.573","article-title":"Differences in adrenal cholesterol, ascorbic acid, circulating corticosterone and aldosterone during the onset of hypertension in SHR vs WKY rats.","volume":"6","author":"Wexler","year":"1982","journal-title":"Cardiovasc Res"},{"key":"2021121010015393800_B20","first-page":"177","article-title":"Effect of vitamin C on blood parameters of hypertensive patients.","volume":"77","author":"Koh","year":"1984","journal-title":"J Okla State Med Assoc"},{"key":"2021121010015393800_B21"},{"key":"2021121010015393800_B22"},{"key":"2021121010015393800_B23","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1749-6632.1975.tb29295.x","article-title":"Clinical pharmacological aspects of ascorbic acid.","volume":"25","author":"Wilson","year":"1975","journal-title":"Ann N Y Acad Sci"},{"key":"2021121010015393800_B24","first-page":"24","article-title":"Scurvy by another name: a case report.","volume":"77","author":"Baumbach","year":"1994","journal-title":"R I Med"},{"key":"2021121010015393800_B25","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1001\/archderm.1984.01650450094028","article-title":"Scurvy: a case caused by peculiar dietary habits.","volume":"120","author":"Ellis","year":"1984","journal-title":"Arch Dematol"},{"key":"2021121010015393800_B26","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1001\/jama.1985.03350300093027","article-title":"Adult scurvy.","volume":"253","author":"Reuler","year":"1985","journal-title":"JAMA"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/108\/3\/e55\/889277\/e55.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/108\/3\/e55\/889277\/e55.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T17:12:00Z","timestamp":1639156320000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/108\/3\/e55\/66588\/An-Orange-a-Day-Keeps-the-Doctor-Away-Scurvy-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,9,1]]},"references-count":26,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2001,9,1]]},"published-print":{"date-parts":[[2001,9,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.108.3.e55","relation":{},"ISSN":["1098-4275","0031-4005"],"issn-type":[{"value":"1098-4275","type":"electronic"},{"value":"0031-4005","type":"print"}],"subject":[],"published":{"date-parts":[[2001,9,1]]}}}