{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:41:19Z","timestamp":1791988879877,"version":"4.4.0"},"reference-count":24,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,10,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective.<\/jats:title>\n                  <jats:p>To assess whether children with history of infantile colic may be at increased risk of subsequently developing asthma and\/or atopy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods.<\/jats:title>\n                  <jats:p>We used data collected in a large, prospective study from an unselected population. Infantile colic and concurrent feeding method were determined from the 2-month well-infant visit form completed by the physician for 983 children who were enrolled at birth. Markers of atopy (total serum immunoglobulin E and allergy skin prick test), allergic rhinitis, asthma, wheezing, and peak flow variability were the main outcome measures studied at different ages between infancy and 11 years.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results.<\/jats:title>\n                  <jats:p>Ninety (9.2%) children had infantile colic. Prevalence of colic was similar among children fed either breast milk or formula. There was no association between infantile colic and markers of atopy, asthma, allergic rhinitis, wheezing, or peak flow variability at any age.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion.<\/jats:title>\n                  <jats:p>Our data cannot support the hypothesis that infantile colic provides increased risk for subsequent allergic disease or atopy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.108.4.878","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T23:55:51Z","timestamp":1092441351000},"page":"878-882","source":"Crossref","is-referenced-by-count":66,"title":["Relation Between Infantile Colic and Asthma\/Atopy:  A Prospective Study in an Unselected Population"],"prefix":"10.1542","volume":"108","author":[{"given":"Jose\u0301 A.","family":"Castro-Rodr\u0131\u0301guez","sequence":"first","affiliation":[{"name":"1 From the Arizona Respiratory Center, University of Arizona, College of Medicine, Tucson, Arizona."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra A.","family":"Stern","sequence":"additional","affiliation":[{"name":"1 From the Arizona Respiratory Center, University of Arizona, College of Medicine, Tucson, Arizona."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn","family":"Halonen","sequence":"additional","affiliation":[{"name":"1 From the Arizona Respiratory Center, University of Arizona, College of Medicine, Tucson, Arizona."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne L.","family":"Wright","sequence":"additional","affiliation":[{"name":"1 From the Arizona Respiratory Center, University of Arizona, College of Medicine, Tucson, Arizona."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharine J.","family":"Holberg","sequence":"additional","affiliation":[{"name":"1 From the Arizona Respiratory Center, University of Arizona, College of Medicine, Tucson, Arizona."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn M.","family":"Taussig","sequence":"additional","affiliation":[{"name":"1 From the Arizona Respiratory Center, University of Arizona, College of Medicine, Tucson, Arizona."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando D.","family":"Martinez","sequence":"additional","affiliation":[{"name":"1 From the Arizona Respiratory Center, University of Arizona, College of Medicine, Tucson, Arizona."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2001,10,1]]},"reference":[{"key":"2021121021523921500_B1","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/j.1651-2227.1996.tb14060.x","article-title":"Infantile colic\u2013less common than previously estimated?","volume":"85","author":"Canivet","year":"1996","journal-title":"Acta Paediatr"},{"key":"2021121021523921500_B2","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1136\/bmj.316.7144.1563","article-title":"Effectiveness of treatments for infantile colic: systematic review [published erratum appears in BMJ. 1998;317:171].","volume":"316","author":"Lucassen","year":"1998","journal-title":"BMJ."},{"key":"2021121021523921500_B3"},{"key":"2021121021523921500_B4","first-page":"403","article-title":"Strategies for consoling the infant with colic: fact or fiction?","volume":"7","author":"Pineyard","year":"1992","journal-title":"J Pediatr Nurs"},{"key":"2021121021523921500_B5","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/S0031-3955(16)38848-4","article-title":"Infant colic. A pediatric gastroenterologist's perspective.","volume":"41","author":"Treem","year":"1994","journal-title":"Pediatr Clin North Am"},{"key":"2021121021523921500_B6","first-page":"276","article-title":"Cow's milk allergy as a cause of infantile colic: immunofluorescent studies on jejunal mucosa.","volume":"13","author":"Harris","year":"1977","journal-title":"Austr Paediatr J"},{"key":"2021121021523921500_B7","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1097\/00005176-199104000-00008","article-title":"Severe infantile colic and food intolerance: a long-term prospective study.","volume":"12","author":"Iacono","year":"1991","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"2021121021523921500_B8","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/BF00445796","article-title":"Infantile colic: occurrence and risk factors.","volume":"143","author":"Stahlberg","year":"1984","journal-title":"Eur J Pediatr"},{"key":"2021121021523921500_B9","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/j.1365-2222.1984.tb02239.x","article-title":"Relationship of diet in the development of atopy in infancy.","volume":"14","author":"Van Asperen","year":"1984","journal-title":"Clin Allergy"},{"key":"2021121021523921500_B10","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1164\/ajrccm.155.4.9105079","article-title":"Alternaria as a major allergen for asthma in children raised in a desert environment.","volume":"155","author":"Halonen","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"2021121021523921500_B11","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0889-8561(05)70344-1","article-title":"Asthma phenotypes: wheezy infants and wheezy children.","volume":"18","author":"Martinez","year":"1998","journal-title":"Immunol Allerg Clin North Am"},{"key":"2021121021523921500_B12"},{"key":"2021121021523921500_B13","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1056\/NEJM199501193320301","article-title":"Asthma and wheezing in the first six years of life. The Group Health Medical Associates [see comments].","volume":"332","author":"Martinez","year":"1995","journal-title":"N Engl J Med"},{"key":"2021121021523921500_B14","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1093\/oxfordjournals.aje.a115242","article-title":"The Tucson Children's Respiratory Study. I. Design and implementation of a prospective study of acute and chronic respiratory illness in children.","volume":"129","author":"Taussig","year":"1989","journal-title":"Am J Epidemiol"},{"key":"2021121021523921500_B15","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1136\/thx.52.11.946","article-title":"Peak flow variability, methacholine responsiveness and atopy as markers for detecting different wheezing phenotypes in childhood [see comments].","volume":"52","author":"Stein","year":"1997","journal-title":"Thorax"},{"key":"2021121021523921500_B16","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/BF00445796","article-title":"Infantile colic: occurrence and risk factors.","volume":"143","author":"Marja-Riitta","year":"1984","journal-title":"Eur J Pediatr"},{"key":"2021121021523921500_B17"},{"key":"2021121021523921500_B18","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1136\/bmj.314.7090.1325","article-title":"The social origins of infantile colic: questionnaire study covering 76\u2009747 infants.","volume":"314","author":"Crowcroft","year":"1997","journal-title":"BMJ"},{"key":"2021121021523921500_B19","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1542\/peds.87.5.623","article-title":"Carrying as colic \u201ctherapy\u201d: a randomized controlled trial.","volume":"87","author":"Barr","year":"1991","journal-title":"Pediatrics"},{"key":"2021121021523921500_B20","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1136\/adc.57.7.559","article-title":"Prevalence of infant colic.","volume":"57","author":"Hide","year":"1982","journal-title":"Arch Dis Child"},{"key":"2021121021523921500_B21","doi-asserted-by":"crossref","first-page":"817","DOI":"10.3928\/0090-4481-19871001-08","article-title":"Present concepts of infant colic.","volume":"16","author":"Adams","year":"1987","journal-title":"Pediatr Ann"},{"key":"2021121021523921500_B22","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1136\/adc.61.12.1232","article-title":"Infantile colic and feeding.","volume":"61","author":"Stahlberg","year":"1986","journal-title":"Arch Dis Child"},{"key":"2021121021523921500_B23","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1136\/bmj.306.6892.1572","article-title":"Relation between early introduction of solid food to infants and their weight and illnesses during the first two years of life [see comments].","volume":"306","author":"Forsyth","year":"1993","journal-title":"BMJ"},{"key":"2021121021523921500_B24","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1542\/peds.18.5.832","article-title":"Allergic colic in infants in the general practice of pediatrics.","volume":"18","author":"Martin","year":"1956","journal-title":"Pediatrics"}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/108\/4\/878\/895462\/pe1001000878.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/108\/4\/878\/895462\/pe1001000878.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,11]],"date-time":"2021-12-11T07:17:52Z","timestamp":1639207072000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/108\/4\/878\/66999\/Relation-Between-Infantile-Colic-and-Asthma-Atopy"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,10,1]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2001,10,1]]},"published-print":{"date-parts":[[2001,10,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.108.4.878","relation":{},"ISSN":["1098-4275","0031-4005"],"issn-type":[{"value":"1098-4275","type":"electronic"},{"value":"0031-4005","type":"print"}],"subject":[],"published":{"date-parts":[[2001,10,1]]}}}