{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T13:20:42Z","timestamp":1774876842285,"version":"3.50.1"},"reference-count":27,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,10,1]]},"abstract":"<jats:sec><jats:title>Objective.<\/jats:title><jats:p>We asked whether neonatal jaundice associated with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency commences either in utero or in the immediate postnatal period and whether this perinatal bilirubinemia is the precursor of the subsequent neonatal jaundice and hyperbilirubinemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods.<\/jats:title><jats:p>Mandatory serum total bilirubin (STB) determinations were performed within 3 hours of birth, to reflect the in utero state (first STB), and on the third day of life (second STB), with additional determinations as clinically necessary, on healthy, term male neonates at high risk for G-6-PD deficiency. G-6-PD Mediterranean mutation was determined by molecular means. G-6-PD\u2013deficient neonates were compared with control participants. The relationship of first STB values to second STB and subsequent hyperbilirubinemia (defined as STB \u2265256 \u03bcmol\/L [15.0 mg\/dL]) was determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>Both first and second STB values were significantly higher in the G-6-PD\u2013deficient neonates (n = 52) than in control participants (n = 166; 50 \u00b1 12 \u03bcmol\/L vs 44 \u00b1 10 \u03bcmol\/L [2.9 \u00b1 0.7 mg\/dL vs 2.6 \u00b1 0.6 mg\/dL] and 174 \u00b1 52 \u03bcmol\/L vs 152 \u00b1 52 \u03bcmol\/L [10.2 \u00b1 3.1 mg\/dL vs 8.9 \u00b1 3.0 mg\/dL] for the first and second STB values, respectively). The rate of rise between these 2 points was greater in the G-6-PD\u2013deficient neonates (2.6 \u00b1 0.9 \u03bcmol\/L\/h vs 2.2 \u00b1 0.9 \u03bcmol\/L\/h [0.15 \u00b1 0.05 mg\/dL\/h vs 0.13 \u00b1 0.05 mg\/dL\/h). Sixteen (30.8%) of the G-6-PD\u2013deficient neonates developed hyperbilirubinemia compared with 10 (6%) of control participants (relative risk: 5.11; 95% confidence interval: 2.47\u201310.56). In both G-6-PD\u2013deficient and normal populations, first STB values correlated significantly with both second STB values and with those who subsequently developed hyperbilirubinemia. Significantly more G-6-PD\u2013deficient neonates with a first STB value greater than or equal to the mean developed hyperbilirubinemia compared with those with first STB less than the mean: 13 of 28 neonates versus 3 of 24 (relative risk: 3.7; 95% confidence interval: 1.20\u201311.51). This difference did not reach statistical significance in the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions.<\/jats:title><jats:p>Higher first STB values, an increased risk of hyperbilirubinemia in G-6-PD\u2013deficient neonates with first STB value greater than or equal to the mean, and significant correlation between first STB values and second STB values and hyperbilirubinemia suggest that jaundice in G-6-PD\u2013deficient neonates commences in the immediate perinatal period, most likely in utero.<\/jats:p><\/jats:sec>","DOI":"10.1542\/peds.108.4.956","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T23:55:51Z","timestamp":1092441351000},"page":"956-959","source":"Crossref","is-referenced-by-count":23,"title":["Onset of Jaundice in Glucose-6-Phosphate Dehydrogenase\u2013Deficient Neonates"],"prefix":"10.1542","volume":"108","author":[{"given":"Michael","family":"Kaplan","sequence":"first","affiliation":[{"name":"From the Department of Neonatology and"},{"name":"the Faculty of Medicine of the Hebrew University, Jerusalem, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nurit","family":"Algur","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry Laboratory, Shaare Zedek Medical Center; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathy","family":"Hammerman","sequence":"additional","affiliation":[{"name":"From the Department of Neonatology and"},{"name":"the Faculty of Medicine of the Hebrew University, Jerusalem, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2001,10,1]]},"reference":[{"key":"2021120819165981000_B1","first-page":"958","article-title":"Hyperbilirubinemia in the newborn.","volume":"61","author":"Davidson","year":"1941","journal-title":"Am J Dis 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