{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:14:10Z","timestamp":1791252850950,"version":"4.1.0"},"reference-count":26,"publisher":"American Academy of Pediatrics (AAP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,10,1]]},"abstract":"\n Objective.<\/jats:title>\n The prevalence rate of all types of limb reduction defects in general and those that potentially are caused by vascular disruption in particular is needed to provide a baseline for the evaluation of infants who are exposed in utero to teratogens that cause vascular disruption. The objective of this study was to determine this prevalence rate.<\/jats:p>\n <\/jats:sec>\n \n Methods.<\/jats:title>\n All infants with any limb deficiency among 161\u2009252 liveborn and stillborn infants and elective terminations were identified in a hospital-based Active Malformations Surveillance Program in Boston in the years 1972 to 1974 and 1979 to 1994. An extensive search was made to identify infants who were missed by the Surveillance Program; an additional 8 infants (7.3% of total) were identified. The limb reduction defects were classified in 3 ways: 1) by the anatomic location of the defect, that is longitudinal, terminal, intercalary, etc; 2) for infants with absence\/hypoplasia of fingers or toes, a tabulation of which digit or digits were affected; and 3) by apparent cause.<\/jats:p>\n <\/jats:sec>\n \n Results.<\/jats:title>\n The prevalence rate for all types of limb deficiency was 0.69\/1000. The apparent causes included single mutant genes, familial occurrence, and known syndromes (24%); chromosome abnormalities (6%); teratogens (4%); vascular disruption (35%); and unknown cause (32%).<\/jats:p>\n <\/jats:sec>\n \n Conclusions.<\/jats:title>\n A hospital-based surveillance program can be used to establish the prevalence of limb reduction defects, if ascertainment is extended to include elective terminations for fetal abnormalities. An apparent cause can be established for most limb defects when the clinical findings are used rather than reliance only on the International Classification of Diseases, Ninth Revision, codes of the discharge diagnoses. The prevalence rate of limb reduction defects as a result of presumed vascular disruption was 0.22\/1000.<\/jats:p>\n <\/jats:sec>","DOI":"10.1542\/peds.108.4.e64","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T23:55:51Z","timestamp":1092441351000},"page":"e64-e64","source":"Crossref","is-referenced-by-count":108,"title":["Limb Deficiencies in Newborn Infants"],"prefix":"10.1542","volume":"108","author":[{"given":"Caroline K.","family":"McGuirk","sequence":"first","affiliation":[{"name":"From the Genetics and Teratology Unit, Pediatric Service, Massachusetts General Hospital, Boston, Massachusetts; the"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Noel","family":"Westgate","sequence":"additional","affiliation":[{"name":"Department of Newborn Medicine, Brigham and Women's Hospital, Boston, Massachusetts; and the"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis 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