{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T07:46:29Z","timestamp":1772869589141,"version":"3.50.1"},"reference-count":36,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,11,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives.<\/jats:title>\n                  <jats:p>We examined parents' perception of the value of treatments designed to reduce the risk of febrile seizure recurrence.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study Design.<\/jats:title>\n                  <jats:p>The families of 42 children with febrile seizures were recruited after pediatric or neuropediatric consultation. A mail questionnaire addressed the family's willingness to pay for a hypothetical treatment for febrile seizures with risk reductions for future febrile seizures of 25%, 50%, 75%, and 100%. The hypothetical clinical scenario was then modified to include the side- effect profiles of either daily phenobarbital or valproic acid, or intermittent diazepam prophylaxis. Covariates included the nature of the child's febrile seizure(s), parents' familiarity with febrile seizures, experiences at the time of febrile seizures or with medication side effects, education and income, and mastery and trait anxiety.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results.<\/jats:title>\n                  <jats:p>Thirty-eight parents, representing 22 of 42 families, completed questionnaires. There was a dramatic inflection in parents' willingness to pay for 100% risk reduction as opposed to 75% or lower risk reductions. Introduction of side effects dramatically reduced the value attached to each level of treatment benefit. Nevertheless, a few parents (3\/38) would pay \u201cas much as it takes\u201d to be rid of their child's recurrence risk.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions.<\/jats:title>\n                  <jats:p>Given the range of value assigned to prophylactic medication for febrile seizures, management strategies for children with febrile seizures must be responsive to the needs and values of individual families.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.108.5.1080","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T23:55:51Z","timestamp":1092441351000},"page":"1080-1088","source":"Crossref","is-referenced-by-count":19,"title":["Treatment of Febrile Seizures: The Influence of Treatment Efficacy and Side-Effect Profile on Value to Parents"],"prefix":"10.1542","volume":"108","author":[{"given":"Kevin E.","family":"Gordon","sequence":"first","affiliation":[{"name":"From the IWK Health Center,"},{"name":"Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph M.","family":"Dooley","sequence":"additional","affiliation":[{"name":"From the IWK Health Center,"},{"name":"Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter R.","family":"Camfield","sequence":"additional","affiliation":[{"name":"From the IWK Health Center,"},{"name":"Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol S.","family":"Camfield","sequence":"additional","affiliation":[{"name":"From the IWK Health Center,"},{"name":"Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"MacSween","sequence":"additional","affiliation":[{"name":"From the IWK Health Center,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"417","published-online":{"date-parts":[[2001,11,1]]},"reference":[{"key":"2021121003531756500_B1","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1136\/bmj.2.6148.1345","article-title":"Febrile convulsions\u2014what do parents do?","volume":"2","author":"Rutter","year":"1978","journal-title":"Br Med J"},{"key":"2021121003531756500_B2","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/j.1469-8749.1981.tb02019.x","article-title":"Many parents think their child is dying when having a first febrile convulsion.","volume":"23","author":"Baumer","year":"1981","journal-title":"Dev Med Child Neurol"},{"key":"2021121003531756500_B3","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/j.1651-2227.1991.tb11883.x","article-title":"Parental reactions to a child's first febrile convulsion.","volume":"80","author":"Balslev","year":"1991","journal-title":"Acta Paediatr Scand"},{"key":"2021121003531756500_B4","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1080\/08035259950169260","article-title":"Parents' fear regarding fever and febrile seizures.","volume":"88","author":"van Stuijvenberg","year":"1999","journal-title":"Acta Paediatr"},{"key":"2021121003531756500_B5","first-page":"B105","article-title":"The use of an educational slide-tape program for parents in the emergency room management of a first febrile seizure.","volume":"13","author":"Bethune","year":"1990","journal-title":"Clin Invest Med"},{"key":"2021121003531756500_B6","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/pch\/6.3.139","article-title":"Parental anxiety and family disruption following a first febrile seizure in childhood.","volume":"6","author":"Wirrell","year":"2001","journal-title":"Paediatr Child Health"},{"key":"2021121003531756500_B7","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1542\/peds.61.5.720","article-title":"Prognosis in children with febrile seizures.","volume":"61","author":"Nelson","year":"1978","journal-title":"Pediatrics"},{"key":"2021121003531756500_B8","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1056\/NEJM197611042951901","article-title":"Predictors of epilepsy in children who have experienced febrile seizures.","volume":"295","author":"Nelson","year":"1976","journal-title":"N Engl J Med"},{"key":"2021121003531756500_B9","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1001\/archneur.1978.00500250021004","article-title":"Febrile seizures and later intellectual performance.","volume":"35","author":"Ellenberg","year":"1978","journal-title":"Arch Neurol"},{"key":"2021121003531756500_B10","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1056\/NEJM199806113382403","article-title":"Long-term intellectual and behavioral outcomes of children with febrile convulsions.","volume":"338","author":"Verity","year":"1998","journal-title":"N Engl J Med"},{"key":"2021121003531756500_B11"},{"key":"2021121003531756500_B12"},{"key":"2021121003531756500_B13"},{"key":"2021121003531756500_B14","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2307\/2136319","article-title":"The structure of coping.","volume":"19","author":"Pearlin","year":"1978","journal-title":"J Health Soc Behav"},{"key":"2021121003531756500_B15"},{"key":"2021121003531756500_B16"},{"key":"2021121003531756500_B17","first-page":"1282","article-title":"Parental anxiety in febrile convulsions.","volume":"32","author":"Shuper","year":"1996","journal-title":"Isr J Med Sci"},{"key":"2021121003531756500_B18","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1528-1157.1999.tb02079.x","article-title":"Referral patterns of family physicians may allow population-based incidence studies of childhood epilepsy.","volume":"40","author":"Speechley","year":"1999","journal-title":"Epilepsia"},{"key":"2021121003531756500_B19","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S0002-8223(98)00203-X","article-title":"Dietitians employed by health care facilities preferred a HACCP system over irradiation or chemical rinses for reducing risk of foodborne disease.","volume":"98","author":"Giamalva","year":"1998","journal-title":"J Am Diet Assoc"},{"key":"2021121003531756500_B20","first-page":"83","article-title":"Perceived benefits of and barriers to participation in a phase I\/II colon cancer chemoprevention trial.","volume":"14","author":"Hudmon","year":"1999","journal-title":"J Cancer Educ"},{"key":"2021121003531756500_B21","first-page":"779","article-title":"How much money are we willing to spend on health services?","volume":"120","author":"Olsen","year":"2000","journal-title":"Tidsskr Nor-Laegeforen"},{"key":"2021121003531756500_B22","first-page":"143","article-title":"Willingness to pay for new chemotherapy for advanced ovarian cancer.","volume":"113","author":"Morris","year":"2000","journal-title":"N Z Med J"},{"key":"2021121003531756500_B23"},{"key":"2021121003531756500_B24","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0887-8994(97)00171-9","article-title":"Effects of an educational program on parents with febrile convulsive children.","volume":"18","author":"Huang","year":"1998","journal-title":"Pediatr Neurol"},{"key":"2021121003531756500_B25","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1053\/seiz.1999.0319","article-title":"Effects of information on parental knowledge of febrile convulsions.","volume":"8","author":"Wassmer","year":"1999","journal-title":"Seizure"},{"key":"2021121003531756500_B26","first-page":"273","article-title":"Behavior and confidence of parents instructed in home management of febrile seizures by rectal diazepam.","volume":"43","author":"Rossi","year":"1988","journal-title":"Helv Paediatr Acta"},{"key":"2021121003531756500_B27","first-page":"12","article-title":"The case for treating febrile seizures.","volume":"9","author":"Rosman","year":"1992","journal-title":"Contemp Pediatr"},{"key":"2021121003531756500_B28","doi-asserted-by":"crossref","first-page":"26","DOI":"10.2165\/00023210-199707010-00004","article-title":"Therapeutic options in the management of febrile seizures.","volume":"7","author":"Rosman","year":"1997","journal-title":"CNS Drugs"},{"key":"2021121003531756500_B29","first-page":"26","article-title":"Febrile seizures: an Rx for parent fears and anxieties.","volume":"10","author":"Camfield","year":"1993","journal-title":"Contemp Pediatr"},{"key":"2021121003531756500_B30","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1528-1157.2000.tb01497.x","article-title":"Febrile seizures: treatment and prognosis.","volume":"41","author":"Knudsen","year":"2000","journal-title":"Epilepsia"},{"key":"2021121003531756500_B31","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1542\/peds.103.6.1307","article-title":"Practice parameter: long-term treatment of the child with simple febrile seizures.","volume":"103","author":"American Academy of Pediatrics, Committee on Quality Improvement, Subcommittee on Febrile Seizures","year":"1999","journal-title":"Pediatrics"},{"key":"2021121003531756500_B32"},{"key":"2021121003531756500_B33"},{"key":"2021121003531756500_B34","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0887-8994(91)90039-N","article-title":"Management of febrile seizures: Survey of current practice and phenobarbital usage.","volume":"7","author":"Millichap","year":"1991","journal-title":"Pediatr Neurol"},{"key":"2021121003531756500_B35","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/S0022-3476(97)70045-3","article-title":"A meta-analytic review of the preventive treatment of recurrences of febrile seizures.","volume":"131","author":"Rantala","year":"1997","journal-title":"J Pediatr"},{"key":"2021121003531756500_B36","first-page":"1401","article-title":"Febrile seizures: a decision-making analysis.","volume":"52","author":"Freeman","year":"1995","journal-title":"Am Fam Physician."}],"container-title":["Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/108\/5\/1080\/892055\/pe1101001080.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/publications.aap.org\/pediatrics\/article-pdf\/108\/5\/1080\/892055\/pe1101001080.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T11:19:46Z","timestamp":1639135186000},"score":1,"resource":{"primary":{"URL":"https:\/\/publications.aap.org\/pediatrics\/article\/108\/5\/1080\/63704\/Treatment-of-Febrile-Seizures-The-Influence-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,11,1]]},"references-count":36,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2001,11,1]]},"published-print":{"date-parts":[[2001,11,1]]}},"URL":"https:\/\/doi.org\/10.1542\/peds.108.5.1080","relation":{},"ISSN":["1098-4275","0031-4005"],"issn-type":[{"value":"1098-4275","type":"electronic"},{"value":"0031-4005","type":"print"}],"subject":[],"published":{"date-parts":[[2001,11,1]]}}}