{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T11:41:36Z","timestamp":1791027696910,"version":"4.1.0"},"reference-count":19,"publisher":"American Academy of Pediatrics (AAP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,11,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective.<\/jats:title>\n                  <jats:p>To determine whether intrapartum antibiotic prophylaxis for neonatal group B streptococcal (GBS) disease has resulted in an increased rate of non-GBS or antibiotic-resistant early-onset invasive neonatal disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods.<\/jats:title>\n                  <jats:p>Maternal and infant chart review of all infants with bacteria other than GBS isolated from blood or spinal fluid in 1996 through 1999 in 19 hospitals (representing 81% of in-state births to state residents) throughout Connecticut. Suspected cases were identified through clinical microbiology laboratory records or throughInternational Classification of Diseases, Ninth Revisioncodes when microbiology records were incomplete.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results.<\/jats:title>\n                  <jats:p>Ninety-four cases of non-GBS early-onset sepsis or meningitis were detected between 1996 and 1999. The rate of GBS-related early-onset infection (days 0\u20136 of life) dropped from 0.61\/1000 to 0.23\/1000 births, but the annual rate of non-GBS sepsis remained steady, ranging from 0.65 to 0.68\/1000 during the surveillance period. There was an increase in the proportion of Escherichia coli infections that were ampicillin resistant between 1996 and 1998, but the proportion decreased. in 1999<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion.<\/jats:title>\n                  <jats:p>There was no increase in the incidence of non-GBS early-onset neonatal infections between 1996 and 1999. Fluctuations in the annual incidence of E coliinfections, including ampicillin-resistant infections, suggest the need for continuation of surveillance in Connecticut and expansion to monitor larger populations.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1542\/peds.108.5.1094","type":"journal-article","created":{"date-parts":[[2004,8,13]],"date-time":"2004-08-13T23:55:51Z","timestamp":1092441351000},"page":"1094-1098","source":"Crossref","is-referenced-by-count":143,"title":["Early-Onset Neonatal Sepsis in the Era of Group B  Streptococcal Prevention"],"prefix":"10.1542","volume":"108","author":[{"given":"Robert S.","family":"Baltimore","sequence":"first","affiliation":[{"name":"From the Departments of Pediatrics and"},{"name":"Epidemiology and Public Health and the"},{"name":"Emerging Infections Program, Yale University School of Medicine, New Haven, Connecticut; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon M.","family":"Huie","sequence":"additional","affiliation":[{"name":"Epidemiology and Public Health and the"},{"name":"Emerging Infections Program, Yale University School of Medicine, New Haven, Connecticut; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James I.","family":"Meek","sequence":"additional","affiliation":[{"name":"Epidemiology and Public Health and the"},{"name":"Emerging Infections Program, Yale University School of Medicine, New Haven, Connecticut; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Schuchat","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, Atlanta, Georgia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine L.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, Atlanta, Georgia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"417","published-online":{"date-parts":[[2001,11,1]]},"reference":[{"key":"2021121003513907300_B1"},{"key":"2021121003513907300_B2"},{"key":"2021121003513907300_B3","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1097\/00006454-199011000-00009","article-title":"A ten-year review of neonatal sepsis and comparison with the previous fifty-year experience.","volume":"9","author":"Gladstone","year":"1990","journal-title":"Pediatr Infect Dis J"},{"key":"2021121003513907300_B4","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1097\/00006454-199412000-00008","article-title":"Bloodstream infections in neonatal intensive care unit patients: results of a multicenter study.","volume":"13","author":"Beck-Sague","year":"1994","journal-title":"Pediatr Infect Dis J"},{"key":"2021121003513907300_B5","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1093\/infdis\/148.5.795","article-title":"Selective intrapartum chemoprophylaxis of neonatal group B streptococcal early-onset disease. 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